Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta
Background Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that...
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| Veröffentlicht in: | Pediatric and developmental pathology 2019-07, Vol.22 (4), p.334-339 |
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| creator | Katzman, Philip J Blitman, Joseph Metlay, Leon A |
| description | Background
Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP.
Methods
The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP.
Results
Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference (P |
| doi_str_mv | 10.1177/1093526619825708 |
| format | Article |
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Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP.
Methods
The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP.
Results
Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference (P < .0001). BCV was present in 6.0% and 3.9% of placentas with or without HDP, respectively, also a significant difference (P < .0001). BCV was more likely than multifocal/focal CV to occur in HDP (32.4% vs 27.4%) when all cases of CV were analyzed (P = .025). Of 221 placentas with MAP, 64% had multifocal/focal CV and 36% had BCV.
Conclusions
BCV and CV are more common in placentas with HDP than in normotensive pregnancies. They are also seen in MAP, as supported by another recent study.</description><identifier>ISSN: 1093-5266</identifier><identifier>EISSN: 1615-5742</identifier><identifier>DOI: 10.1177/1093526619825708</identifier><identifier>PMID: 30665335</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Chorionic Villi - immunology ; Chorionic Villi - pathology ; Female ; Fetal Growth Retardation - immunology ; Fetal Growth Retardation - pathology ; Humans ; Hypertension, Pregnancy-Induced - immunology ; Hypertension, Pregnancy-Induced - pathology ; Inflammation - pathology ; Placenta - immunology ; Placenta - pathology ; Placenta Accreta - immunology ; Placenta Accreta - pathology ; Pre-Eclampsia - immunology ; Pre-Eclampsia - pathology ; Pregnancy</subject><ispartof>Pediatric and developmental pathology, 2019-07, Vol.22 (4), p.334-339</ispartof><rights>2019, Society for Pediatric Pathology All rights reserved</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-7e8a403872396aba9d82787b93893ee71afc1cad1dc29cfab16c6d6c17880e5b3</citedby><cites>FETCH-LOGICAL-c337t-7e8a403872396aba9d82787b93893ee71afc1cad1dc29cfab16c6d6c17880e5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1093526619825708$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1093526619825708$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30665335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katzman, Philip J</creatorcontrib><creatorcontrib>Blitman, Joseph</creatorcontrib><creatorcontrib>Metlay, Leon A</creatorcontrib><title>Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta</title><title>Pediatric and developmental pathology</title><addtitle>Pediatr Dev Pathol</addtitle><description>Background
Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP.
Methods
The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP.
Results
Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference (P < .0001). BCV was present in 6.0% and 3.9% of placentas with or without HDP, respectively, also a significant difference (P < .0001). BCV was more likely than multifocal/focal CV to occur in HDP (32.4% vs 27.4%) when all cases of CV were analyzed (P = .025). Of 221 placentas with MAP, 64% had multifocal/focal CV and 36% had BCV.
Conclusions
BCV and CV are more common in placentas with HDP than in normotensive pregnancies. They are also seen in MAP, as supported by another recent study.</description><subject>Chorionic Villi - immunology</subject><subject>Chorionic Villi - pathology</subject><subject>Female</subject><subject>Fetal Growth Retardation - immunology</subject><subject>Fetal Growth Retardation - pathology</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - immunology</subject><subject>Hypertension, Pregnancy-Induced - pathology</subject><subject>Inflammation - pathology</subject><subject>Placenta - immunology</subject><subject>Placenta - pathology</subject><subject>Placenta Accreta - immunology</subject><subject>Placenta Accreta - pathology</subject><subject>Pre-Eclampsia - immunology</subject><subject>Pre-Eclampsia - pathology</subject><subject>Pregnancy</subject><issn>1093-5266</issn><issn>1615-5742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UctOGzEUtSpQobT7rpCXbKbY44zt6S6EV6Qgsmi7HXnsO4nBYwd7plW-qT-JaQCpSKyur85L1wehr5R8o1SIU0pqVpWc01qWlSDyAzqknFZFJSblXn5nuHjCD9CnlO4IyRpOPqIDRjivGKsO0d8zlZTDs3UM3mr8yzpnB5uw8gaf2xSigZhw6PCwBrx0SoMfMn-nyvsA3_EUL0NKtnWA530_-uDCyuqML6y_x2cw_AHw-Hq7gTiAT_Y3_G-9jLDyyuvtv9SbEFtr3BZPzRpijnuN_Yz2O-USfHmeR-jn5cWP2XWxuL2az6aLQjMmhkKAVBPCpChZzVWraiNLIUVbM1kzAEFVp6lWhhpd1rpTLeWaG66pkJJA1bIjdLLz3cTwMEIamt4mDc4pD2FMTUlFPaGScJKpZEfVMX9BhK7ZRNuruG0oaZ4qat5WlCXHz-5j24N5Fbx0kgnFjpDUCpq7MEafr33f8BEzf5ta</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Katzman, Philip J</creator><creator>Blitman, Joseph</creator><creator>Metlay, Leon A</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201907</creationdate><title>Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta</title><author>Katzman, Philip J ; Blitman, Joseph ; Metlay, Leon A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-7e8a403872396aba9d82787b93893ee71afc1cad1dc29cfab16c6d6c17880e5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chorionic Villi - immunology</topic><topic>Chorionic Villi - pathology</topic><topic>Female</topic><topic>Fetal Growth Retardation - immunology</topic><topic>Fetal Growth Retardation - pathology</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - immunology</topic><topic>Hypertension, Pregnancy-Induced - pathology</topic><topic>Inflammation - pathology</topic><topic>Placenta - immunology</topic><topic>Placenta - pathology</topic><topic>Placenta Accreta - immunology</topic><topic>Placenta Accreta - pathology</topic><topic>Pre-Eclampsia - immunology</topic><topic>Pre-Eclampsia - pathology</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katzman, Philip J</creatorcontrib><creatorcontrib>Blitman, Joseph</creatorcontrib><creatorcontrib>Metlay, Leon A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric and developmental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katzman, Philip J</au><au>Blitman, Joseph</au><au>Metlay, Leon A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta</atitle><jtitle>Pediatric and developmental pathology</jtitle><addtitle>Pediatr Dev Pathol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>22</volume><issue>4</issue><spage>334</spage><epage>339</epage><pages>334-339</pages><issn>1093-5266</issn><eissn>1615-5742</eissn><abstract>Background
Hypertensive disorders of pregnancy (HDP) are a common cause for preterm delivery. Prior studies showed that chronic villitis (CV) is associated with intrauterine growth restriction, preeclampsia, intrauterine fetal death, and morbidly adherent placenta (MAP). The authors hypothesize that disorders of the placental basal plate, especially basal chronic villitis (BCV), are associated with HDP.
Methods
The laboratory information system was queried over 12 years to identify placentas with or without the clinical history of HDP and with or without multifocal/focal CV or BCV. As a control for tissue sampling, a similar search was performed over 5 years for placentas evaluated for MAP.
Results
Of 19,683 placentas identified, 14.8% had CV which was in 18.5% and 14.2% of placentas associated with or without HDP, respectively, a significant difference (P < .0001). BCV was present in 6.0% and 3.9% of placentas with or without HDP, respectively, also a significant difference (P < .0001). BCV was more likely than multifocal/focal CV to occur in HDP (32.4% vs 27.4%) when all cases of CV were analyzed (P = .025). Of 221 placentas with MAP, 64% had multifocal/focal CV and 36% had BCV.
Conclusions
BCV and CV are more common in placentas with HDP than in normotensive pregnancies. They are also seen in MAP, as supported by another recent study.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>30665335</pmid><doi>10.1177/1093526619825708</doi><tpages>6</tpages></addata></record> |
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| subjects | Chorionic Villi - immunology Chorionic Villi - pathology Female Fetal Growth Retardation - immunology Fetal Growth Retardation - pathology Humans Hypertension, Pregnancy-Induced - immunology Hypertension, Pregnancy-Induced - pathology Inflammation - pathology Placenta - immunology Placenta - pathology Placenta Accreta - immunology Placenta Accreta - pathology Pre-Eclampsia - immunology Pre-Eclampsia - pathology Pregnancy |
| title | Basal Chronic Villitis and Disorders of the Placental Basal Plate: A Possible Immunological Link Between Hypertensive Disorders of Pregnancy and Morbidly Adherent Placenta |
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