In silico designed RNA aptamer against epithelial cell adhesion molecule for cancer cell imaging

Aptamers are short, single-stranded oligonucleotides that bind to their targets with high affinity and specificity. Usually, aptamers are selected experimentally using SELEX approach. Here, we describe a computational approach for selection of aptamers for proteins, which involves generation of a vi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2019-02, Vol.509 (4), p.937-942
Hauptverfasser:	Bavi, Rohit, Liu, Zicun, Han, Zhihao, Zhang, Hang, Gu, Yueqing
Format:	Artikel
Sprache:	eng
Schlagworte:	EpCAM Flow cytometry assays Inhibition of endocytosis MD simulation RNA aptamer Virtual screening
Online-Zugang:	Volltext
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