HEMA modulates the transcription of genes related to oxidative defense, inflammatory response and organization of the ECM in human oral cells

•HEMA induces genes of the oxidative defense machinery in both cell types after 24h.•HEMA concurrently modulates genes related to inflammation and ECM remodeling.•Regulation of some genes differed at 10mM HEMA compared to lower concentrations. 2-Hydroxyethyl methacrylate (HEMA) is a widely used mono...

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Veröffentlicht in:	Dental materials 2019-03, Vol.35 (3), p.501-510
Hauptverfasser:	Perduns, Renke, Volk, Joachim, Schertl, Peter, Leyhausen, Gabriele, Geurtsen, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Composite materials Cytotoxicity Dental materials Dental restorative materials Dentistry Detoxification ECM Elution Extracellular matrix Fibroblasts Gene expression Genes Gingival fibroblasts HEMA Homeostasis Impact analysis Inflammation Inflammatory response Keratinocytes Oral keratinocytes Oxidative stress Polyhydroxyethyl methacrylate Polymer matrix composites Polymerase chain reaction Resins Tissues Toxicity Transcription
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