A case of nasal low-grade non-intestinal-type adenocarcinoma with aberrant CDX2 expression and a novel SYN2-PPARG gene fusion in a 13-year-old girl

We report the first patient (a 13-year-old girl) with a sinonasal low-grade non-intestinal-type adenocarcinoma showing aberrant CDX2 expression both within morular areas and in the tubular component and demonstrate for the first time a SYN2-PPARG gene fusion in this tumor type. The tumor arose from...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 2019-05, Vol.474 (5), p.619-623
Hauptverfasser:	Soon, Gwyneth Shook Ting, Chang, Kenneth Tou En, Kuick, Chik Hong, Petersson, Fredrik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adolescent Biomarkers, Tumor - metabolism Brief Report CDX2 protein CDX2 Transcription Factor - genetics CDX2 Transcription Factor - metabolism Female Gene expression Gene fusion Gene Fusion - physiology Homeodomain Proteins - metabolism Humans Immunohistochemistry Intestine Medicine Medicine & Public Health Nasal Cavity - pathology Nose Paranasal Sinus Neoplasms - diagnosis Paranasal Sinus Neoplasms - pathology Pathology Peroxisome proliferator-activated receptors PPAR gamma - metabolism Septum Tumors
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