Sustained release of GDF5 from a designed coacervate attenuates disc degeneration in a rat model

[Display omitted] Low back pain is often caused by intervertebral disc degeneration, which is characterized by nucleus pulposus (NP) and extracellular matrix (ECM) degeneration. Human adipose-derived stem cells (hADSCs) induced by growth and differentiation factor-5 (GDF5) can differentiate into an...

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Veröffentlicht in:	Acta biomaterialia 2019-03, Vol.86, p.300-311
Hauptverfasser:	Zhu, Jian, Xia, Kaishun, Yu, Wei, Wang, Yitian, Hua, Jianming, Liu, Bing, Gong, Zhe, Wang, Junjie, Xu, Ankai, You, Zhengwei, Chen, Qixin, Li, Fangcai, Tao, Huimin, Liang, Chengzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Attenuation Cell Differentiation - drug effects Cell Proliferation - drug effects Collagen Type II - metabolism Controlled release Degeneration Delayed-Action Preparations - pharmacology Delayed-Action Preparations - therapeutic use Differentiation Disease Models, Animal Extracellular matrix Gene Expression Regulation - drug effects Gene therapy Growth differentiation factor 5 Growth Differentiation Factor 5 - pharmacology Growth Differentiation Factor 5 - therapeutic use Growth factor therapy Growth factors Heparin Human adipose-derived stem cells Humans Intervertebral disc Intervertebral Disc - diagnostic imaging Intervertebral Disc - pathology Intervertebral Disc Degeneration - diagnostic imaging Intervertebral Disc Degeneration - drug therapy Intervertebral Disc Degeneration - pathology Intervertebral discs Life span Low back pain Magnetic Resonance Imaging Moisture content Nuclei (cytology) Nucleus pulposus Nucleus Pulposus - pathology Pain Peptides - chemical synthesis Peptides - chemistry Phenotype Phenotypes Polyelectrolytes Polyesters - chemical synthesis Polyesters - chemistry Rats, Sprague-Dawley Spine Stem cell transplantation Stem cells Stem Cells - cytology Stem Cells - drug effects Stem Cells - metabolism Sustained release Vertebrae Water content
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