A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery

Ketoconazole is a broad-spectrum antifungal agent, which has recently been characterized as a potential anticancer agent in several cancer types. However, the molecular mechanism underlying the anticancer effect of ketoconazole is not clearly defined. Our recent findings demonstrate that ketoconazol...

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Veröffentlicht in:	Autophagy 2019-04, Vol.15 (4), p.733-734
Hauptverfasser:	Chen, Hai-Ning, Chen, Yan, Zhou, Zong-Guang, Wei, Yuquan, Huang, Canhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Autophagy Carcinoma, Hepatocellular Cyclooxygenase 2 hepatocellular carcinoma Humans Ketoconazole Liver Neoplasms Mitophagy Protein Kinases PTGS2
Online-Zugang:	Volltext
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