Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides

Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The established systems for engineering are combined with novel app...

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Veröffentlicht in:	Applied microbiology and biotechnology 2019-03, Vol.103 (5), p.2053-2066
Hauptverfasser:	Plavec, Tina Vida, Berlec, Aleš
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Bacteria Bacterial Proteins - genetics Bacterial Proteins - therapeutic use Biological Products - metabolism Biological Products - therapeutic use Biomedical and Life Sciences Biopharmaceuticals Biotechnology Cancer Containment CRISPR Drug delivery systems Engineering Food industry Food processing industry Gastrointestinal diseases Gene Editing - methods Genetic aspects Genomes Health Health aspects Humans Infection Inflammatory bowel diseases Intestine Lactic acid Lactic acid bacteria Lactobacillus - genetics Lactobacillus - metabolism Lactococcus lactis - genetics Lactococcus lactis - metabolism Life Sciences Methods Microbial genetic engineering Microbial Genetics and Genomics Microbiology Mini-Review Peptides Protein Engineering - methods Proteins Therapy Vectors Yogurt
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