Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides
Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The established systems for engineering are combined with novel app...
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| Veröffentlicht in: | Applied microbiology and biotechnology 2019-03, Vol.103 (5), p.2053-2066 |
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| creator | Plavec, Tina Vida Berlec, Aleš |
| description | Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The established systems for engineering are combined with novel approaches, such as CRISPR-Cas, to enable the use of LAB as vectors for delivery of various therapeutic molecules. The latter are either secreted or surface displayed and can be used for the treatment or prevention of numerous conditions: inflammatory bowel diseases, infections, autoimmune diseases, and even cancer. This review presents some recent data on engineering of LAB, with the emphasis on the most commonly used genera
Lactococcus
and
Lactobacillus
. Their use for the delivery of therapeutic proteins is discussed, while a special focus is given to the delivery of therapeutic peptides. Therapeutically relevant improvements of engineered LAB, such as containment systems, ability to visualize bacteria, or target specific host cells are also addressed. Future engineering of LAB for therapy will adopt the capabilities of synthetic biology, with first examples already emerging. |
| doi_str_mv | 10.1007/s00253-019-09628-y |
| format | Article |
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Lactococcus
and
Lactobacillus
. Their use for the delivery of therapeutic proteins is discussed, while a special focus is given to the delivery of therapeutic peptides. Therapeutically relevant improvements of engineered LAB, such as containment systems, ability to visualize bacteria, or target specific host cells are also addressed. Future engineering of LAB for therapy will adopt the capabilities of synthetic biology, with first examples already emerging.</description><identifier>ISSN: 0175-7598</identifier><identifier>EISSN: 1432-0614</identifier><identifier>DOI: 10.1007/s00253-019-09628-y</identifier><identifier>PMID: 30656391</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Autoimmune diseases ; Bacteria ; Bacterial Proteins - genetics ; Bacterial Proteins - therapeutic use ; Biological Products - metabolism ; Biological Products - therapeutic use ; Biomedical and Life Sciences ; Biopharmaceuticals ; Biotechnology ; Cancer ; Containment ; CRISPR ; Drug delivery systems ; Engineering ; Food industry ; Food processing industry ; Gastrointestinal diseases ; Gene Editing - methods ; Genetic aspects ; Genomes ; Health ; Health aspects ; Humans ; Infection ; Inflammatory bowel diseases ; Intestine ; Lactic acid ; Lactic acid bacteria ; Lactobacillus - genetics ; Lactobacillus - metabolism ; Lactococcus lactis - genetics ; Lactococcus lactis - metabolism ; Life Sciences ; Methods ; Microbial genetic engineering ; Microbial Genetics and Genomics ; Microbiology ; Mini-Review ; Peptides ; Protein Engineering - methods ; Proteins ; Therapy ; Vectors ; Yogurt</subject><ispartof>Applied microbiology and biotechnology, 2019-03, Vol.103 (5), p.2053-2066</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Applied Microbiology and Biotechnology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-4e5872c4c74ce860906323c3fda07b0bfd7975cb1b682ec168cec5f80962b2e63</citedby><cites>FETCH-LOGICAL-c513t-4e5872c4c74ce860906323c3fda07b0bfd7975cb1b682ec168cec5f80962b2e63</cites><orcidid>0000-0002-8095-6998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00253-019-09628-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00253-019-09628-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30656391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plavec, Tina Vida</creatorcontrib><creatorcontrib>Berlec, Aleš</creatorcontrib><title>Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides</title><title>Applied microbiology and biotechnology</title><addtitle>Appl Microbiol Biotechnol</addtitle><addtitle>Appl Microbiol Biotechnol</addtitle><description>Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The established systems for engineering are combined with novel approaches, such as CRISPR-Cas, to enable the use of LAB as vectors for delivery of various therapeutic molecules. The latter are either secreted or surface displayed and can be used for the treatment or prevention of numerous conditions: inflammatory bowel diseases, infections, autoimmune diseases, and even cancer. This review presents some recent data on engineering of LAB, with the emphasis on the most commonly used genera
Lactococcus
and
Lactobacillus
. Their use for the delivery of therapeutic proteins is discussed, while a special focus is given to the delivery of therapeutic peptides. Therapeutically relevant improvements of engineered LAB, such as containment systems, ability to visualize bacteria, or target specific host cells are also addressed. Future engineering of LAB for therapy will adopt the capabilities of synthetic biology, with first examples already emerging.</description><subject>Autoimmune diseases</subject><subject>Bacteria</subject><subject>Bacterial Proteins - genetics</subject><subject>Bacterial Proteins - therapeutic use</subject><subject>Biological Products - metabolism</subject><subject>Biological Products - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biopharmaceuticals</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Containment</subject><subject>CRISPR</subject><subject>Drug delivery systems</subject><subject>Engineering</subject><subject>Food industry</subject><subject>Food processing industry</subject><subject>Gastrointestinal diseases</subject><subject>Gene Editing - methods</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Health</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Inflammatory bowel diseases</subject><subject>Intestine</subject><subject>Lactic acid</subject><subject>Lactic acid bacteria</subject><subject>Lactobacillus - genetics</subject><subject>Lactobacillus - metabolism</subject><subject>Lactococcus lactis - genetics</subject><subject>Lactococcus lactis - metabolism</subject><subject>Life Sciences</subject><subject>Methods</subject><subject>Microbial genetic engineering</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Mini-Review</subject><subject>Peptides</subject><subject>Protein Engineering - methods</subject><subject>Proteins</subject><subject>Therapy</subject><subject>Vectors</subject><subject>Yogurt</subject><issn>0175-7598</issn><issn>1432-0614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rFTEYhYMo9lr9Ay5kwI0upuZj8rUspWqhIKhdh0zmzTVlbmZMMsX77814q-WKSBYJyXMO78lB6CXBZwRj-S5jTDlrMdEt1oKqdv8IbUjHaIsF6R6jDSaSt5JrdYKe5XyLMaFKiKfohGHBBdNkg24u4zZEgBTitpl8M1pXgmusC0PT13N9sI2fUjPAGO4g7VeofINkZ1hWck5TgRBzY-PQzDCXMEB-jp54O2Z4cb-fopv3l18vPrbXnz5cXZxft44TVtoOuJLUdU52DpTAGgtGmWN-sFj2uPeD1JK7nvRCUXBEKAeOe7Wm7SkIdoreHHzrFN8XyMXsQnYwjjbCtGRDidRMCy1JRV__hd5OS4p1ukoJVb-GCP1Abe0IJkQ_lWTdamrOuVRihWSlzv5B1TXALrgpgg_1_kjw9khQmQI_ytYuOZurL5-PWXpgXZpyTuDNnMLOpr0h2Ky9m0PvpvZufvVu9lX06j7d0u9g-CP5XXQF2AHI81o1pIf4_7H9CfpctjU</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Plavec, Tina Vida</creator><creator>Berlec, Aleš</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>LK8</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8095-6998</orcidid></search><sort><creationdate>20190301</creationdate><title>Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides</title><author>Plavec, Tina Vida ; Berlec, Aleš</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-4e5872c4c74ce860906323c3fda07b0bfd7975cb1b682ec168cec5f80962b2e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Autoimmune diseases</topic><topic>Bacteria</topic><topic>Bacterial Proteins - 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Academic</collection><jtitle>Applied microbiology and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plavec, Tina Vida</au><au>Berlec, Aleš</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides</atitle><jtitle>Applied microbiology and biotechnology</jtitle><stitle>Appl Microbiol Biotechnol</stitle><addtitle>Appl Microbiol Biotechnol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>103</volume><issue>5</issue><spage>2053</spage><epage>2066</epage><pages>2053-2066</pages><issn>0175-7598</issn><eissn>1432-0614</eissn><abstract>Lactic acid bacteria (LAB) have a long-term history of use in food industry and are becoming attractive for use in therapy on account of their safety, intrinsic beneficial health effects, and considerable biotechnological potential. The established systems for engineering are combined with novel approaches, such as CRISPR-Cas, to enable the use of LAB as vectors for delivery of various therapeutic molecules. The latter are either secreted or surface displayed and can be used for the treatment or prevention of numerous conditions: inflammatory bowel diseases, infections, autoimmune diseases, and even cancer. This review presents some recent data on engineering of LAB, with the emphasis on the most commonly used genera
Lactococcus
and
Lactobacillus
. Their use for the delivery of therapeutic proteins is discussed, while a special focus is given to the delivery of therapeutic peptides. Therapeutically relevant improvements of engineered LAB, such as containment systems, ability to visualize bacteria, or target specific host cells are also addressed. Future engineering of LAB for therapy will adopt the capabilities of synthetic biology, with first examples already emerging.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30656391</pmid><doi>10.1007/s00253-019-09628-y</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-8095-6998</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Applied microbiology and biotechnology, 2019-03, Vol.103 (5), p.2053-2066 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Autoimmune diseases Bacteria Bacterial Proteins - genetics Bacterial Proteins - therapeutic use Biological Products - metabolism Biological Products - therapeutic use Biomedical and Life Sciences Biopharmaceuticals Biotechnology Cancer Containment CRISPR Drug delivery systems Engineering Food industry Food processing industry Gastrointestinal diseases Gene Editing - methods Genetic aspects Genomes Health Health aspects Humans Infection Inflammatory bowel diseases Intestine Lactic acid Lactic acid bacteria Lactobacillus - genetics Lactobacillus - metabolism Lactococcus lactis - genetics Lactococcus lactis - metabolism Life Sciences Methods Microbial genetic engineering Microbial Genetics and Genomics Microbiology Mini-Review Peptides Protein Engineering - methods Proteins Therapy Vectors Yogurt |
| title | Engineering of lactic acid bacteria for delivery of therapeutic proteins and peptides |
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