Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach
Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of c...
Gespeichert in:
| Veröffentlicht in: | Indian journal of pediatrics 2019-08, Vol.86 (8), p.717-724 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 724 |
|---|---|
| container_issue | 8 |
| container_start_page | 717 |
| container_title | Indian journal of pediatrics |
| container_volume | 86 |
| creator | Schaaf, H. Simon |
| description | Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only |
| doi_str_mv | 10.1007/s12098-018-02846-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179396810</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179396810</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-227be2a21835d39314b5dbaeff10e8c8606d62bf0a91a08cea6edbd710c278033</originalsourceid><addsrcrecordid>eNp9kM1PwyAchonROL_-AQ-mRy_VH7BS8LbMz2RGY-ZVQuHXraajE9qD_724qUdDCASe9yU8hJxSuKAA5WWkDJTMgabJ5FjkcoccgCp5XgrFd9MeqMqLcSFG5DDGdwCmQKh9MuIgijTggLxdN2bhu9jEzHiXPRpvFrhC32ddnT0Obd-4MCzyF0xEb9LxfKgw2KHdRBqfTZdN6wL6q2ySPQdj-8aaNpus16EzdnlM9mrTRjz5WY_I6-3NfHqfz57uHqaTWW75uOxzxsoKmWFU8sJxxem4KlxlsK4poLRSgHCCVTUYRQ1Ii0agq1xJwbJSAudH5Hzbm579GDD2etVEi21rPHZD1IyWiishKSSUbVEbuhgD1nodmpUJn5qC_vaqt1518qo3XrVMobOf_qFaofuL_IpMAN8CMV35BQb93g3Bpz__V_sFdhiD0w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179396810</pqid></control><display><type>article</type><title>Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Schaaf, H. Simon</creator><creatorcontrib>Schaaf, H. Simon</creatorcontrib><description>Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only <5% of children with MDR-TB are currently diagnosed and appropriately treated. Diagnosing children with MDR-TB and getting them on to correct treatment regimens should now be our main focus.</description><identifier>ISSN: 0019-5456</identifier><identifier>EISSN: 0973-7693</identifier><identifier>DOI: 10.1007/s12098-018-02846-8</identifier><identifier>PMID: 30656560</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Administration, Oral ; Antitubercular Agents - administration & dosage ; Antitubercular Agents - therapeutic use ; Child ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Gynecology ; Humans ; Medicine ; Medicine & Public Health ; Microbial Sensitivity Tests ; Pediatrics ; Review Article ; Tuberculosis, Multidrug-Resistant - diagnosis ; Tuberculosis, Multidrug-Resistant - drug therapy</subject><ispartof>Indian journal of pediatrics, 2019-08, Vol.86 (8), p.717-724</ispartof><rights>Dr. K C Chaudhuri Foundation 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-227be2a21835d39314b5dbaeff10e8c8606d62bf0a91a08cea6edbd710c278033</citedby><cites>FETCH-LOGICAL-c347t-227be2a21835d39314b5dbaeff10e8c8606d62bf0a91a08cea6edbd710c278033</cites><orcidid>0000-0001-5755-4133</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12098-018-02846-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12098-018-02846-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30656560$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaaf, H. Simon</creatorcontrib><title>Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach</title><title>Indian journal of pediatrics</title><addtitle>Indian J Pediatr</addtitle><addtitle>Indian J Pediatr</addtitle><description>Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only <5% of children with MDR-TB are currently diagnosed and appropriately treated. Diagnosing children with MDR-TB and getting them on to correct treatment regimens should now be our main focus.</description><subject>Administration, Oral</subject><subject>Antitubercular Agents - administration & dosage</subject><subject>Antitubercular Agents - therapeutic use</subject><subject>Child</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Gynecology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microbial Sensitivity Tests</subject><subject>Pediatrics</subject><subject>Review Article</subject><subject>Tuberculosis, Multidrug-Resistant - diagnosis</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><issn>0019-5456</issn><issn>0973-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1PwyAchonROL_-AQ-mRy_VH7BS8LbMz2RGY-ZVQuHXraajE9qD_724qUdDCASe9yU8hJxSuKAA5WWkDJTMgabJ5FjkcoccgCp5XgrFd9MeqMqLcSFG5DDGdwCmQKh9MuIgijTggLxdN2bhu9jEzHiXPRpvFrhC32ddnT0Obd-4MCzyF0xEb9LxfKgw2KHdRBqfTZdN6wL6q2ySPQdj-8aaNpus16EzdnlM9mrTRjz5WY_I6-3NfHqfz57uHqaTWW75uOxzxsoKmWFU8sJxxem4KlxlsK4poLRSgHCCVTUYRQ1Ii0agq1xJwbJSAudH5Hzbm579GDD2etVEi21rPHZD1IyWiishKSSUbVEbuhgD1nodmpUJn5qC_vaqt1518qo3XrVMobOf_qFaofuL_IpMAN8CMV35BQb93g3Bpz__V_sFdhiD0w</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Schaaf, H. Simon</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5755-4133</orcidid></search><sort><creationdate>20190801</creationdate><title>Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach</title><author>Schaaf, H. Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-227be2a21835d39314b5dbaeff10e8c8606d62bf0a91a08cea6edbd710c278033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Administration, Oral</topic><topic>Antitubercular Agents - administration & dosage</topic><topic>Antitubercular Agents - therapeutic use</topic><topic>Child</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Gynecology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microbial Sensitivity Tests</topic><topic>Pediatrics</topic><topic>Review Article</topic><topic>Tuberculosis, Multidrug-Resistant - diagnosis</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaaf, H. Simon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaaf, H. Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach</atitle><jtitle>Indian journal of pediatrics</jtitle><stitle>Indian J Pediatr</stitle><addtitle>Indian J Pediatr</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>86</volume><issue>8</issue><spage>717</spage><epage>724</epage><pages>717-724</pages><issn>0019-5456</issn><eissn>0973-7693</eissn><abstract>Approximately 25,000 children develop multidrug-resistant (MDR) tuberculosis (TB) each year, but few of them are diagnosed and appropriately treated for MDR-TB. New diagnostic tools have improved our ability to diagnose children with bacteriologically confirmed TB earlier. However, the majority of childhood TB cases are not bacteriologically confirmed; therefore a high index of suspicion is needed, and taking a detailed history of contact with drug-resistant source cases and previous TB treatment is important to identify presumed MDR-TB cases. Treatment for MDR-TB is rapidly changing with the addition of new and repurposed drugs, the introduction of shorter regimens and the move towards injectable-free, all-oral MDR-TB treatment regimens. Children have been neglected in the introduction of the new drugs, but drug dosing and safety studies are now being completed. This article presents a practical approach in deciding which regimen to use in individual children in need of MDR-TB treatment. Outcomes in those treated are generally good, but only <5% of children with MDR-TB are currently diagnosed and appropriately treated. Diagnosing children with MDR-TB and getting them on to correct treatment regimens should now be our main focus.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>30656560</pmid><doi>10.1007/s12098-018-02846-8</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5755-4133</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0019-5456 |
| ispartof | Indian journal of pediatrics, 2019-08, Vol.86 (8), p.717-724 |
| issn | 0019-5456 0973-7693 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179396810 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Administration, Oral Antitubercular Agents - administration & dosage Antitubercular Agents - therapeutic use Child Dose-Response Relationship, Drug Drug Administration Schedule Gynecology Humans Medicine Medicine & Public Health Microbial Sensitivity Tests Pediatrics Review Article Tuberculosis, Multidrug-Resistant - diagnosis Tuberculosis, Multidrug-Resistant - drug therapy |
| title | Diagnosis and Management of Multidrug-Resistant Tuberculosis in Children: A Practical Approach |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T21%3A18%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnosis%20and%20Management%20of%20Multidrug-Resistant%20Tuberculosis%20in%20Children:%20A%20Practical%20Approach&rft.jtitle=Indian%20journal%20of%20pediatrics&rft.au=Schaaf,%20H.%20Simon&rft.date=2019-08-01&rft.volume=86&rft.issue=8&rft.spage=717&rft.epage=724&rft.pages=717-724&rft.issn=0019-5456&rft.eissn=0973-7693&rft_id=info:doi/10.1007/s12098-018-02846-8&rft_dat=%3Cproquest_cross%3E2179396810%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2179396810&rft_id=info:pmid/30656560&rfr_iscdi=true |