Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI
The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. Thus, this study looked at the...
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| Veröffentlicht in: | Diabetes & metabolism 2019-10, Vol.45 (5), p.473-479 |
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| creator | Martin-Rodriguez, J.L. Gonzalez-Cantero, J. Gonzalez-Cantero, A. Martí-Bonmatí, L. Alberich-Bayarri, Á. Gonzalez-Cejudo, T. Gonzalez-Calvin, J.L. |
| description | The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. Thus, this study looked at the relationship of intrahepatic iron and serum TNF-α with intrahepatic triglycerides and IR in non-diabetic adults.
In this cross-sectional study of 104 healthy non-diabetic Caucasians, a quantitative magnetic resonance (MR) imaging T2 gradient-echo technique was used to measure hepatic iron, with 1H-MR spectroscopy used to measure hepatic triglycerides. HOMA-IR was calculated to determine IR.
The prevalence of hepatic iron overload (HIOL) was 26.6% in individuals with NAFLD vs. 0% in those without. IR was present in 87.5% of subjects with both NAFLD and HIOL, in 45.4% of those with NAFLD but not HIOL, and in 4.5% of those with neither. HOMA-IR was positively correlated with hepatic triglycerides (r = 0.56, P |
| doi_str_mv | 10.1016/j.diabet.2019.01.005 |
| format | Article |
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In this cross-sectional study of 104 healthy non-diabetic Caucasians, a quantitative magnetic resonance (MR) imaging T2 gradient-echo technique was used to measure hepatic iron, with 1H-MR spectroscopy used to measure hepatic triglycerides. HOMA-IR was calculated to determine IR.
The prevalence of hepatic iron overload (HIOL) was 26.6% in individuals with NAFLD vs. 0% in those without. IR was present in 87.5% of subjects with both NAFLD and HIOL, in 45.4% of those with NAFLD but not HIOL, and in 4.5% of those with neither. HOMA-IR was positively correlated with hepatic triglycerides (r = 0.56, P < 0.001) and hepatic iron (r = 0.52, P < 0.001), whereas serum TNF-α concentrations correlated with intrahepatic triglyceride levels (r = 0.28, P < 0.04), but not with intrahepatic iron. Hepatic triglycerides, serum TNF-α and age were the only significant determinants of IR in regression analyses.
IR is closely associated with intrahepatic triglycerides and, to a lesser extent, intrahepatic iron, with some interplay between them. High serum TNF-α concentrations may contribute to the association between NAFLD and IR, while increased hepatic triglycerides appear to be a determinant of the development of HIOL in non-diabetic subjects without haemochromatosis.</description><identifier>ISSN: 1262-3636</identifier><identifier>EISSN: 1878-1780</identifier><identifier>DOI: 10.1016/j.diabet.2019.01.005</identifier><identifier>PMID: 30660761</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Adult ; Age Factors ; Aged ; Cross-Sectional Studies ; Female ; Hepatic iron ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Iron - analysis ; Liver - diagnostic imaging ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged ; NAFLD ; Non-alcoholic Fatty Liver Disease - blood ; Non-alcoholic Fatty Liver Disease - diagnostic imaging ; TNF-α ; Triglycerides - blood ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Diabetes & metabolism, 2019-10, Vol.45 (5), p.473-479</ispartof><rights>2019 Elsevier Masson SAS</rights><rights>Copyright © 2019 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-ad07a4dc5c4decd371030087662856d5724216401d2458852df6382e0939fe513</citedby><cites>FETCH-LOGICAL-c362t-ad07a4dc5c4decd371030087662856d5724216401d2458852df6382e0939fe513</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1262363619300205$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30660761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin-Rodriguez, J.L.</creatorcontrib><creatorcontrib>Gonzalez-Cantero, J.</creatorcontrib><creatorcontrib>Gonzalez-Cantero, A.</creatorcontrib><creatorcontrib>Martí-Bonmatí, L.</creatorcontrib><creatorcontrib>Alberich-Bayarri, Á.</creatorcontrib><creatorcontrib>Gonzalez-Cejudo, T.</creatorcontrib><creatorcontrib>Gonzalez-Calvin, J.L.</creatorcontrib><title>Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI</title><title>Diabetes & metabolism</title><addtitle>Diabetes Metab</addtitle><description>The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. Thus, this study looked at the relationship of intrahepatic iron and serum TNF-α with intrahepatic triglycerides and IR in non-diabetic adults.
In this cross-sectional study of 104 healthy non-diabetic Caucasians, a quantitative magnetic resonance (MR) imaging T2 gradient-echo technique was used to measure hepatic iron, with 1H-MR spectroscopy used to measure hepatic triglycerides. HOMA-IR was calculated to determine IR.
The prevalence of hepatic iron overload (HIOL) was 26.6% in individuals with NAFLD vs. 0% in those without. IR was present in 87.5% of subjects with both NAFLD and HIOL, in 45.4% of those with NAFLD but not HIOL, and in 4.5% of those with neither. HOMA-IR was positively correlated with hepatic triglycerides (r = 0.56, P < 0.001) and hepatic iron (r = 0.52, P < 0.001), whereas serum TNF-α concentrations correlated with intrahepatic triglyceride levels (r = 0.28, P < 0.04), but not with intrahepatic iron. Hepatic triglycerides, serum TNF-α and age were the only significant determinants of IR in regression analyses.
IR is closely associated with intrahepatic triglycerides and, to a lesser extent, intrahepatic iron, with some interplay between them. High serum TNF-α concentrations may contribute to the association between NAFLD and IR, while increased hepatic triglycerides appear to be a determinant of the development of HIOL in non-diabetic subjects without haemochromatosis.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Hepatic iron</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Iron - analysis</subject><subject>Liver - diagnostic imaging</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NAFLD</subject><subject>Non-alcoholic Fatty Liver Disease - blood</subject><subject>Non-alcoholic Fatty Liver Disease - diagnostic imaging</subject><subject>TNF-α</subject><subject>Triglycerides - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>1262-3636</issn><issn>1878-1780</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3DAQgK2qVaHAG1TIx16Sju3EcTggIcqWlRaQVnC2jD3b9SrrBDsp4rH6In2mGhY49jSj0Td_HyFfGZQMmPy-KZ039ziWHFhbAisB6g9kn6lGFaxR8DHnXPJCSCH3yJeUNgCMt0J9JnsCpIRGsn2S5iFNnQ80YvJpNMEiNcHR67PZ4scJXWJnRt-HtPYDffTjmvowRrPGIZct9bEPL3jCOG3p7fWs-PuHTsmHX5Rd0qslTQPaMfbJ9sPTC3m1nB-STyvTJTx6jQfkbnZxe35ZLG5-zs_PFoUVko-FcdCYytnaVg6tEw0DAaAaKbmqpasbXnEmK2COV7VSNXcrKRRHaEW7wpqJA_JtN3eI_cOEadRbnyx2nQnYT0lz1mS0VlWb0WqH2nxrirjSQ_RbE580A_2sW2_0Trd-1q2B6aw7tx2_bpjut-jem978ZuB0B2D-87fHqJP1mCU7H7MY7Xr__w3_AO27kZM</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Martin-Rodriguez, J.L.</creator><creator>Gonzalez-Cantero, J.</creator><creator>Gonzalez-Cantero, A.</creator><creator>Martí-Bonmatí, L.</creator><creator>Alberich-Bayarri, Á.</creator><creator>Gonzalez-Cejudo, T.</creator><creator>Gonzalez-Calvin, J.L.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201910</creationdate><title>Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI</title><author>Martin-Rodriguez, J.L. ; Gonzalez-Cantero, J. ; Gonzalez-Cantero, A. ; Martí-Bonmatí, L. ; Alberich-Bayarri, Á. ; Gonzalez-Cejudo, T. ; Gonzalez-Calvin, J.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-ad07a4dc5c4decd371030087662856d5724216401d2458852df6382e0939fe513</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Hepatic iron</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Iron - analysis</topic><topic>Liver - diagnostic imaging</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NAFLD</topic><topic>Non-alcoholic Fatty Liver Disease - blood</topic><topic>Non-alcoholic Fatty Liver Disease - diagnostic imaging</topic><topic>TNF-α</topic><topic>Triglycerides - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin-Rodriguez, J.L.</creatorcontrib><creatorcontrib>Gonzalez-Cantero, J.</creatorcontrib><creatorcontrib>Gonzalez-Cantero, A.</creatorcontrib><creatorcontrib>Martí-Bonmatí, L.</creatorcontrib><creatorcontrib>Alberich-Bayarri, Á.</creatorcontrib><creatorcontrib>Gonzalez-Cejudo, T.</creatorcontrib><creatorcontrib>Gonzalez-Calvin, J.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin-Rodriguez, J.L.</au><au>Gonzalez-Cantero, J.</au><au>Gonzalez-Cantero, A.</au><au>Martí-Bonmatí, L.</au><au>Alberich-Bayarri, Á.</au><au>Gonzalez-Cejudo, T.</au><au>Gonzalez-Calvin, J.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI</atitle><jtitle>Diabetes & metabolism</jtitle><addtitle>Diabetes Metab</addtitle><date>2019-10</date><risdate>2019</risdate><volume>45</volume><issue>5</issue><spage>473</spage><epage>479</epage><pages>473-479</pages><issn>1262-3636</issn><eissn>1878-1780</eissn><abstract>The association of non-alcoholic fatty liver disease (NAFLD) with insulin resistance (IR) is well established, yet little is known of their possible relationship with intrahepatic iron and serum tumour necrosis factor (TNF)-α concentrations in adults without diabetes. Thus, this study looked at the relationship of intrahepatic iron and serum TNF-α with intrahepatic triglycerides and IR in non-diabetic adults.
In this cross-sectional study of 104 healthy non-diabetic Caucasians, a quantitative magnetic resonance (MR) imaging T2 gradient-echo technique was used to measure hepatic iron, with 1H-MR spectroscopy used to measure hepatic triglycerides. HOMA-IR was calculated to determine IR.
The prevalence of hepatic iron overload (HIOL) was 26.6% in individuals with NAFLD vs. 0% in those without. IR was present in 87.5% of subjects with both NAFLD and HIOL, in 45.4% of those with NAFLD but not HIOL, and in 4.5% of those with neither. HOMA-IR was positively correlated with hepatic triglycerides (r = 0.56, P < 0.001) and hepatic iron (r = 0.52, P < 0.001), whereas serum TNF-α concentrations correlated with intrahepatic triglyceride levels (r = 0.28, P < 0.04), but not with intrahepatic iron. Hepatic triglycerides, serum TNF-α and age were the only significant determinants of IR in regression analyses.
IR is closely associated with intrahepatic triglycerides and, to a lesser extent, intrahepatic iron, with some interplay between them. High serum TNF-α concentrations may contribute to the association between NAFLD and IR, while increased hepatic triglycerides appear to be a determinant of the development of HIOL in non-diabetic subjects without haemochromatosis.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>30660761</pmid><doi>10.1016/j.diabet.2019.01.005</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetes & metabolism, 2019-10, Vol.45 (5), p.473-479 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Age Factors Aged Cross-Sectional Studies Female Hepatic iron Humans Insulin resistance Insulin Resistance - physiology Iron - analysis Liver - diagnostic imaging Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Middle Aged NAFLD Non-alcoholic Fatty Liver Disease - blood Non-alcoholic Fatty Liver Disease - diagnostic imaging TNF-α Triglycerides - blood Tumor Necrosis Factor-alpha - blood |
| title | Insulin resistance and NAFLD: Relationship with intrahepatic iron and serum TNF-α using 1H MR spectroscopy and MRI |
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