N-Alkyl amide synthesis via N-alkylation of amides with alcohols
N -Alkyl amides have wide applications in the biological, pharmaceutical and organic chemical industry. Accordingly, their synthesis has attracted great attention. Among different methods, the N -alkylation of amides with alcohols constitutes an attractive process for their synthesis because alcohol...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2019-02, Vol.17 (8), p.244-254 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Dai, Xingchao Shi, Feng |
| description | N
-Alkyl amides have wide applications in the biological, pharmaceutical and organic chemical industry. Accordingly, their synthesis has attracted great attention. Among different methods, the
N
-alkylation of amides with alcohols constitutes an attractive process for their synthesis because alcohol is readily available, and water is generated as the sole byproduct. Although considerable progress has been made in the area of the direct coupling of amides with alcohols in the past few decades, the review on this aspect is almost vacant. This review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.
The present review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts. |
| doi_str_mv | 10.1039/c8ob03091j |
| format | Article |
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-Alkyl amides have wide applications in the biological, pharmaceutical and organic chemical industry. Accordingly, their synthesis has attracted great attention. Among different methods, the
N
-alkylation of amides with alcohols constitutes an attractive process for their synthesis because alcohol is readily available, and water is generated as the sole byproduct. Although considerable progress has been made in the area of the direct coupling of amides with alcohols in the past few decades, the review on this aspect is almost vacant. This review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.
The present review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.</description><identifier>ISSN: 1477-0520</identifier><identifier>EISSN: 1477-0539</identifier><identifier>DOI: 10.1039/c8ob03091j</identifier><identifier>PMID: 30656316</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Alcohol ; Alcohols ; Alkylation ; Amides ; Catalysts ; Chemical industry ; Chemical synthesis ; Organic chemicals ; Organic chemistry</subject><ispartof>Organic & biomolecular chemistry, 2019-02, Vol.17 (8), p.244-254</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-784de6c14c2ed3dfed775c90ff62045ef1c7732c2ba4c3a5150a549411b0c45a3</citedby><cites>FETCH-LOGICAL-c363t-784de6c14c2ed3dfed775c90ff62045ef1c7732c2ba4c3a5150a549411b0c45a3</cites><orcidid>0000-0002-9623-3743 ; 0000-0001-5665-4933</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30656316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dai, Xingchao</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><title>N-Alkyl amide synthesis via N-alkylation of amides with alcohols</title><title>Organic & biomolecular chemistry</title><addtitle>Org Biomol Chem</addtitle><description>N
-Alkyl amides have wide applications in the biological, pharmaceutical and organic chemical industry. Accordingly, their synthesis has attracted great attention. Among different methods, the
N
-alkylation of amides with alcohols constitutes an attractive process for their synthesis because alcohol is readily available, and water is generated as the sole byproduct. Although considerable progress has been made in the area of the direct coupling of amides with alcohols in the past few decades, the review on this aspect is almost vacant. This review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.
The present review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.</description><subject>Alcohol</subject><subject>Alcohols</subject><subject>Alkylation</subject><subject>Amides</subject><subject>Catalysts</subject><subject>Chemical industry</subject><subject>Chemical synthesis</subject><subject>Organic chemicals</subject><subject>Organic chemistry</subject><issn>1477-0520</issn><issn>1477-0539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp90c1LwzAYBvAgipvTi3el4kWEatJ8NTfn8JOxXfRc0jRhnW0zm1bpf29m5wQPnt7A8-Pl5QkAxwheIYjFtYptCjEUaLkDhohwHkKKxe72HcEBOHBuCSESnJF9MMCQUYYRG4KbWTgu3roikGWe6cB1VbPQLnfBRy6DWSjXmWxyWwXW9MYFn3mzCGSh7MIW7hDsGVk4fbSZI_B6f_cyeQyn84enyXgaKsxwE_KYZJopRFSkM5wZnXFOlYDGsAgSqg1SnONIRakkCkuKKJSUCIJQChWhEo_ARb93Vdv3VrsmKXOndFHIStvWJRHiAovI9-Dp-R-6tG1d-eu8irGIIWLUq8teqdo6V2uTrOq8lHWXIJise00m8fz2u9dnj083K9u01NmW_hTpwUkPaqe26e_H-PzsvzxZZQZ_AdGFhjk</recordid><startdate>20190220</startdate><enddate>20190220</enddate><creator>Dai, Xingchao</creator><creator>Shi, Feng</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9623-3743</orcidid><orcidid>https://orcid.org/0000-0001-5665-4933</orcidid></search><sort><creationdate>20190220</creationdate><title>N-Alkyl amide synthesis via N-alkylation of amides with alcohols</title><author>Dai, Xingchao ; Shi, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-784de6c14c2ed3dfed775c90ff62045ef1c7732c2ba4c3a5150a549411b0c45a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Alcohols</topic><topic>Alkylation</topic><topic>Amides</topic><topic>Catalysts</topic><topic>Chemical industry</topic><topic>Chemical synthesis</topic><topic>Organic chemicals</topic><topic>Organic chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Xingchao</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Organic & biomolecular chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Xingchao</au><au>Shi, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-Alkyl amide synthesis via N-alkylation of amides with alcohols</atitle><jtitle>Organic & biomolecular chemistry</jtitle><addtitle>Org Biomol Chem</addtitle><date>2019-02-20</date><risdate>2019</risdate><volume>17</volume><issue>8</issue><spage>244</spage><epage>254</epage><pages>244-254</pages><issn>1477-0520</issn><eissn>1477-0539</eissn><abstract>N
-Alkyl amides have wide applications in the biological, pharmaceutical and organic chemical industry. Accordingly, their synthesis has attracted great attention. Among different methods, the
N
-alkylation of amides with alcohols constitutes an attractive process for their synthesis because alcohol is readily available, and water is generated as the sole byproduct. Although considerable progress has been made in the area of the direct coupling of amides with alcohols in the past few decades, the review on this aspect is almost vacant. This review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.
The present review summarizes the recent development of
N
-alkylation of amides with alcohols according to the classification of catalysts.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>30656316</pmid><doi>10.1039/c8ob03091j</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9623-3743</orcidid><orcidid>https://orcid.org/0000-0001-5665-4933</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2019-02, Vol.17 (8), p.244-254 |
| issn | 1477-0520 1477-0539 |
| language | eng |
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| source | Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Alcohol Alcohols Alkylation Amides Catalysts Chemical industry Chemical synthesis Organic chemicals Organic chemistry |
| title | N-Alkyl amide synthesis via N-alkylation of amides with alcohols |
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