Sequence specificity of amylin-insulin interaction: a fragment-based insulin fibrillation inhibition study

Subcutaneous insulin delivery serves as the major treatment for the ever-increasing spread of type II diabetes worldwide. However, long-term exposure to insulin results in local aggregates at the site of injection. This therapeutic concern accentuates the need to develop newer effective excipients t...

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Veröffentlicht in:	Biochimica et biophysica acta. Proteins and proteomics 2019-04, Vol.1867 (4), p.405-415
Hauptverfasser:	Ratha, Bhisma Narayan, Kar, Rajiv K., Kalita, Sujan, Kalita, Sourav, Raha, Sreyan, Singha, Achintya, Garai, Kanchan, Mandal, Bhubaneswar, Bhunia, Anirban
Format:	Artikel
Sprache:	eng
Schlagworte:	AFM Amyloid hIAPP Insulin NMR β-Breaker inhibitor
Online-Zugang:	Volltext
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