Na,K-ATPase α-subunit conformation determines glutathionylation efficiency

The functioning of the N, K-ATPase depends on the redox status of cells and its activity is inhibited by oxidative stress and hypoxia. We previously found that redox sensitivity of the Na,K-ATPase is mediated by glutathionylation of the α-subunit. An increase in the level of glutathionylation of cys...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemical and biophysical research communications 2019-02, Vol.510 (1), p.86-90
Hauptverfasser:	Poluektov, Yuri M., Dergousova, Elena A., Lopina, Olga D., Mitkevich, Vladimir A., Makarov, Alexander A., Petrushanko, Irina Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Conformational changes Cysteine residues availability Molecular modelling Na,K-ATPase Ouabain S-Glutathionylation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!