Biocatalytic Strategies towards [4+2] Cycloadditions

Long sought after [4+2] cyclases have sprouted up in numerous biosynthetic pathways in recent years, raising hopes for biocatalytic solutions to cycloaddition catalysis, an important problem in chemical synthesis. In a few cases, detailed pictures of the inner workings of these catalysts have emerge...

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Veröffentlicht in:	Chemistry : a European journal 2019-05, Vol.25 (28), p.6864-6877
Hauptverfasser:	Lichman, Benjamin R., O'Connor, Sarah E., Kries, Hajo
Format:	Artikel
Sprache:	eng
Schlagworte:	[4+2] cyclase biocatalysis Catalysis Catalysts Chemical synthesis Chemistry Computer applications Crystallography Cycloaddition Diels–Alderase Domains enzyme design enzyme mechanism Enzymes Organic chemistry Pictures
Online-Zugang:	Volltext
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