Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity
Abstract Objective Obesity is an independent risk factor for chronic kidney disease. Recently, urinary mitochondrial DNA (mtDNA) has been used as a surrogate marker of mitochondrial damage in various kidney diseases. However, there are no data regarding its use in patients with obesity or the change...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2019-06, Vol.104 (6), p.2257-2266 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | Lee, Haekyung Oh, Songhee Yang, Wonmi Park, Rojin Kim, Hyoungnae Jeon, Jin Seok Noh, Hyunjin Han, Dong Cheol Cho, Kae Won Kim, Yong Jin Kwon, Soon Hyo |
| description | Abstract
Objective
Obesity is an independent risk factor for chronic kidney disease. Recently, urinary mitochondrial DNA (mtDNA) has been used as a surrogate marker of mitochondrial damage in various kidney diseases. However, there are no data regarding its use in patients with obesity or the change in urinary mtDNA copy number after surgery.
Design
We prospectively recruited age- and sex-matched healthy volunteers and patients with obesity (n = 22 in each group: nine men and 13 women). The copy number of urinary and serum mtDNA nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) and cytochrome-c oxidase 3 (mtCOX-3) was measured using quantitative PCR. We measured urinary mtDNA and body weight and carried out laboratory tests, 6 months after surgery.
Results
Urinary mtND-1 copy number was significantly higher in the obese group than in healthy volunteers. However, urinary mtCOX-3 and serum ND-1 copy numbers in the obese group did not differ from that in the healthy volunteers. When patients with obesity were divided into two groups, according to their baseline mtND-1 copy number, bariatric surgery reduced the mtND-1 copy number (P = 0.006) in the high baseline mtDNA copy-number group. The change in urinary mtND-1 copy number was correlated with a change in urinary albumin (r = 0.478, P = 0.025).
Conclusions
Obesity is associated with elevated urinary mtND-1 copy number. Bariatric surgery reduces the elevated urinary mtND-1 copy number in patients with obesity. This suggests that bariatric surgery could attenuate mitochondrial damage in the kidney cells of patients with obesity.
Obese patients have elevated urinary mitochondrial DNA (mtDNA) copy number. Bariatric surgery reduces especially high urinary mtDNA copy number. |
| doi_str_mv | 10.1210/jc.2018-01935 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179378706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1210/jc.2018-01935</oup_id><sourcerecordid>2179378706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-613b4f4270a21439c9c01cde869b1108a51e359853a0894d94650494274c0ee23</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhq0K1G4LR67IEhcuKTO2E8fHsvRLKm0FVHCzHGeWepVNtrZTaf89WbaAhNTTHOZ5X42eYewNwjEKhA9LfywA6wLQyHKPzdCostBo9As2AxBYGC1-HLDDlJYAqFQp99mBhKrURsOMuY8uBpdj8PzrGH9S3PAv1I6eEj_t6NFlavldDL2bFp9DHvz90LdTouOfrk_4fFhv-PW4aijy0PNblwP1OfHvId_zm4ZSyJtX7OXCdYleP80jdnd2-m1-UVzdnF_OT64KL43MRYWyUQslNDiBShpvPKBvqa5Mgwi1K5FkaepSOqiNao2qSlBmCigPREIesfe73nUcHkZK2a5C8tR1rqdhTFagNlLXGqoJffcfuhzG2E_XWSErJZSoxZYqdpSPQ0qRFnYdw2oSYRHs1r1dert1b3-7n_i3T61js6L2L_1H9r8Lh3H9XNfuj_IXybaI4g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2364242826</pqid></control><display><type>article</type><title>Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>ProQuest Central</source><creator>Lee, Haekyung ; Oh, Songhee ; Yang, Wonmi ; Park, Rojin ; Kim, Hyoungnae ; Jeon, Jin Seok ; Noh, Hyunjin ; Han, Dong Cheol ; Cho, Kae Won ; Kim, Yong Jin ; Kwon, Soon Hyo</creator><creatorcontrib>Lee, Haekyung ; Oh, Songhee ; Yang, Wonmi ; Park, Rojin ; Kim, Hyoungnae ; Jeon, Jin Seok ; Noh, Hyunjin ; Han, Dong Cheol ; Cho, Kae Won ; Kim, Yong Jin ; Kwon, Soon Hyo</creatorcontrib><description>Abstract
Objective
Obesity is an independent risk factor for chronic kidney disease. Recently, urinary mitochondrial DNA (mtDNA) has been used as a surrogate marker of mitochondrial damage in various kidney diseases. However, there are no data regarding its use in patients with obesity or the change in urinary mtDNA copy number after surgery.
Design
We prospectively recruited age- and sex-matched healthy volunteers and patients with obesity (n = 22 in each group: nine men and 13 women). The copy number of urinary and serum mtDNA nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) and cytochrome-c oxidase 3 (mtCOX-3) was measured using quantitative PCR. We measured urinary mtDNA and body weight and carried out laboratory tests, 6 months after surgery.
Results
Urinary mtND-1 copy number was significantly higher in the obese group than in healthy volunteers. However, urinary mtCOX-3 and serum ND-1 copy numbers in the obese group did not differ from that in the healthy volunteers. When patients with obesity were divided into two groups, according to their baseline mtND-1 copy number, bariatric surgery reduced the mtND-1 copy number (P = 0.006) in the high baseline mtDNA copy-number group. The change in urinary mtND-1 copy number was correlated with a change in urinary albumin (r = 0.478, P = 0.025).
Conclusions
Obesity is associated with elevated urinary mtND-1 copy number. Bariatric surgery reduces the elevated urinary mtND-1 copy number in patients with obesity. This suggests that bariatric surgery could attenuate mitochondrial damage in the kidney cells of patients with obesity.
Obese patients have elevated urinary mitochondrial DNA (mtDNA) copy number. Bariatric surgery reduces especially high urinary mtDNA copy number.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2018-01935</identifier><identifier>PMID: 30657970</identifier><language>eng</language><publisher>Washington, DC: Endocrine Society</publisher><subject>Adenine ; Adult ; Bariatric Surgery ; Body weight ; Copy number ; Cytochrome-c oxidase ; Deoxyribonucleic acid ; DNA ; DNA, Mitochondrial - urine ; Electron Transport Complex IV - blood ; Electron Transport Complex IV - urine ; Female ; Gastrointestinal surgery ; Gene Dosage ; Glomerular Filtration Rate ; Humans ; Kidney diseases ; Male ; Mitochondrial DNA ; NAD ; NADH Dehydrogenase - blood ; NADH Dehydrogenase - urine ; Nicotinamide ; Obesity ; Obesity - genetics ; Prospective Studies ; Risk factors ; Surgery</subject><ispartof>The journal of clinical endocrinology and metabolism, 2019-06, Vol.104 (6), p.2257-2266</ispartof><rights>Copyright © 2019 Endocrine Society 2019</rights><rights>Copyright © 2019 Endocrine Society.</rights><rights>Copyright © 2019 Endocrine Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-613b4f4270a21439c9c01cde869b1108a51e359853a0894d94650494274c0ee23</citedby><cites>FETCH-LOGICAL-c393t-613b4f4270a21439c9c01cde869b1108a51e359853a0894d94650494274c0ee23</cites><orcidid>0000-0002-4114-4196</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2364242826?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,21367,27901,27902,33721,33722,43781</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30657970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Haekyung</creatorcontrib><creatorcontrib>Oh, Songhee</creatorcontrib><creatorcontrib>Yang, Wonmi</creatorcontrib><creatorcontrib>Park, Rojin</creatorcontrib><creatorcontrib>Kim, Hyoungnae</creatorcontrib><creatorcontrib>Jeon, Jin Seok</creatorcontrib><creatorcontrib>Noh, Hyunjin</creatorcontrib><creatorcontrib>Han, Dong Cheol</creatorcontrib><creatorcontrib>Cho, Kae Won</creatorcontrib><creatorcontrib>Kim, Yong Jin</creatorcontrib><creatorcontrib>Kwon, Soon Hyo</creatorcontrib><title>Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Objective
Obesity is an independent risk factor for chronic kidney disease. Recently, urinary mitochondrial DNA (mtDNA) has been used as a surrogate marker of mitochondrial damage in various kidney diseases. However, there are no data regarding its use in patients with obesity or the change in urinary mtDNA copy number after surgery.
Design
We prospectively recruited age- and sex-matched healthy volunteers and patients with obesity (n = 22 in each group: nine men and 13 women). The copy number of urinary and serum mtDNA nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) and cytochrome-c oxidase 3 (mtCOX-3) was measured using quantitative PCR. We measured urinary mtDNA and body weight and carried out laboratory tests, 6 months after surgery.
Results
Urinary mtND-1 copy number was significantly higher in the obese group than in healthy volunteers. However, urinary mtCOX-3 and serum ND-1 copy numbers in the obese group did not differ from that in the healthy volunteers. When patients with obesity were divided into two groups, according to their baseline mtND-1 copy number, bariatric surgery reduced the mtND-1 copy number (P = 0.006) in the high baseline mtDNA copy-number group. The change in urinary mtND-1 copy number was correlated with a change in urinary albumin (r = 0.478, P = 0.025).
Conclusions
Obesity is associated with elevated urinary mtND-1 copy number. Bariatric surgery reduces the elevated urinary mtND-1 copy number in patients with obesity. This suggests that bariatric surgery could attenuate mitochondrial damage in the kidney cells of patients with obesity.
Obese patients have elevated urinary mitochondrial DNA (mtDNA) copy number. Bariatric surgery reduces especially high urinary mtDNA copy number.</description><subject>Adenine</subject><subject>Adult</subject><subject>Bariatric Surgery</subject><subject>Body weight</subject><subject>Copy number</subject><subject>Cytochrome-c oxidase</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Mitochondrial - urine</subject><subject>Electron Transport Complex IV - blood</subject><subject>Electron Transport Complex IV - urine</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Gene Dosage</subject><subject>Glomerular Filtration Rate</subject><subject>Humans</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Mitochondrial DNA</subject><subject>NAD</subject><subject>NADH Dehydrogenase - blood</subject><subject>NADH Dehydrogenase - urine</subject><subject>Nicotinamide</subject><subject>Obesity</subject><subject>Obesity - genetics</subject><subject>Prospective Studies</subject><subject>Risk factors</subject><subject>Surgery</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1v1DAQhq0K1G4LR67IEhcuKTO2E8fHsvRLKm0FVHCzHGeWepVNtrZTaf89WbaAhNTTHOZ5X42eYewNwjEKhA9LfywA6wLQyHKPzdCostBo9As2AxBYGC1-HLDDlJYAqFQp99mBhKrURsOMuY8uBpdj8PzrGH9S3PAv1I6eEj_t6NFlavldDL2bFp9DHvz90LdTouOfrk_4fFhv-PW4aijy0PNblwP1OfHvId_zm4ZSyJtX7OXCdYleP80jdnd2-m1-UVzdnF_OT64KL43MRYWyUQslNDiBShpvPKBvqa5Mgwi1K5FkaepSOqiNao2qSlBmCigPREIesfe73nUcHkZK2a5C8tR1rqdhTFagNlLXGqoJffcfuhzG2E_XWSErJZSoxZYqdpSPQ0qRFnYdw2oSYRHs1r1dert1b3-7n_i3T61js6L2L_1H9r8Lh3H9XNfuj_IXybaI4g</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Lee, Haekyung</creator><creator>Oh, Songhee</creator><creator>Yang, Wonmi</creator><creator>Park, Rojin</creator><creator>Kim, Hyoungnae</creator><creator>Jeon, Jin Seok</creator><creator>Noh, Hyunjin</creator><creator>Han, Dong Cheol</creator><creator>Cho, Kae Won</creator><creator>Kim, Yong Jin</creator><creator>Kwon, Soon Hyo</creator><general>Endocrine Society</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4114-4196</orcidid></search><sort><creationdate>20190601</creationdate><title>Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity</title><author>Lee, Haekyung ; Oh, Songhee ; Yang, Wonmi ; Park, Rojin ; Kim, Hyoungnae ; Jeon, Jin Seok ; Noh, Hyunjin ; Han, Dong Cheol ; Cho, Kae Won ; Kim, Yong Jin ; Kwon, Soon Hyo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-613b4f4270a21439c9c01cde869b1108a51e359853a0894d94650494274c0ee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenine</topic><topic>Adult</topic><topic>Bariatric Surgery</topic><topic>Body weight</topic><topic>Copy number</topic><topic>Cytochrome-c oxidase</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Mitochondrial - urine</topic><topic>Electron Transport Complex IV - blood</topic><topic>Electron Transport Complex IV - urine</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Gene Dosage</topic><topic>Glomerular Filtration Rate</topic><topic>Humans</topic><topic>Kidney diseases</topic><topic>Male</topic><topic>Mitochondrial DNA</topic><topic>NAD</topic><topic>NADH Dehydrogenase - blood</topic><topic>NADH Dehydrogenase - urine</topic><topic>Nicotinamide</topic><topic>Obesity</topic><topic>Obesity - genetics</topic><topic>Prospective Studies</topic><topic>Risk factors</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Haekyung</creatorcontrib><creatorcontrib>Oh, Songhee</creatorcontrib><creatorcontrib>Yang, Wonmi</creatorcontrib><creatorcontrib>Park, Rojin</creatorcontrib><creatorcontrib>Kim, Hyoungnae</creatorcontrib><creatorcontrib>Jeon, Jin Seok</creatorcontrib><creatorcontrib>Noh, Hyunjin</creatorcontrib><creatorcontrib>Han, Dong Cheol</creatorcontrib><creatorcontrib>Cho, Kae Won</creatorcontrib><creatorcontrib>Kim, Yong Jin</creatorcontrib><creatorcontrib>Kwon, Soon Hyo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Haekyung</au><au>Oh, Songhee</au><au>Yang, Wonmi</au><au>Park, Rojin</au><au>Kim, Hyoungnae</au><au>Jeon, Jin Seok</au><au>Noh, Hyunjin</au><au>Han, Dong Cheol</au><au>Cho, Kae Won</au><au>Kim, Yong Jin</au><au>Kwon, Soon Hyo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>104</volume><issue>6</issue><spage>2257</spage><epage>2266</epage><pages>2257-2266</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Objective
Obesity is an independent risk factor for chronic kidney disease. Recently, urinary mitochondrial DNA (mtDNA) has been used as a surrogate marker of mitochondrial damage in various kidney diseases. However, there are no data regarding its use in patients with obesity or the change in urinary mtDNA copy number after surgery.
Design
We prospectively recruited age- and sex-matched healthy volunteers and patients with obesity (n = 22 in each group: nine men and 13 women). The copy number of urinary and serum mtDNA nicotinamide adenine dinucleotide dehydrogenase subunit-1 (mtND-1) and cytochrome-c oxidase 3 (mtCOX-3) was measured using quantitative PCR. We measured urinary mtDNA and body weight and carried out laboratory tests, 6 months after surgery.
Results
Urinary mtND-1 copy number was significantly higher in the obese group than in healthy volunteers. However, urinary mtCOX-3 and serum ND-1 copy numbers in the obese group did not differ from that in the healthy volunteers. When patients with obesity were divided into two groups, according to their baseline mtND-1 copy number, bariatric surgery reduced the mtND-1 copy number (P = 0.006) in the high baseline mtDNA copy-number group. The change in urinary mtND-1 copy number was correlated with a change in urinary albumin (r = 0.478, P = 0.025).
Conclusions
Obesity is associated with elevated urinary mtND-1 copy number. Bariatric surgery reduces the elevated urinary mtND-1 copy number in patients with obesity. This suggests that bariatric surgery could attenuate mitochondrial damage in the kidney cells of patients with obesity.
Obese patients have elevated urinary mitochondrial DNA (mtDNA) copy number. Bariatric surgery reduces especially high urinary mtDNA copy number.</abstract><cop>Washington, DC</cop><pub>Endocrine Society</pub><pmid>30657970</pmid><doi>10.1210/jc.2018-01935</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4114-4196</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; ProQuest Central |
| subjects | Adenine Adult Bariatric Surgery Body weight Copy number Cytochrome-c oxidase Deoxyribonucleic acid DNA DNA, Mitochondrial - urine Electron Transport Complex IV - blood Electron Transport Complex IV - urine Female Gastrointestinal surgery Gene Dosage Glomerular Filtration Rate Humans Kidney diseases Male Mitochondrial DNA NAD NADH Dehydrogenase - blood NADH Dehydrogenase - urine Nicotinamide Obesity Obesity - genetics Prospective Studies Risk factors Surgery |
| title | Bariatric Surgery Reduces Elevated Urinary Mitochondrial DNA Copy Number in Patients With Obesity |
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