One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths
AIMS One‐hour post‐load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1‐hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi‐ethnic cohort of youths with...
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| Veröffentlicht in: | Diabetes, obesity & metabolism obesity & metabolism, 2019-05, Vol.21 (5), p.1191-1198 |
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| container_title | Diabetes, obesity & metabolism |
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| creator | Tricò, Domenico Galderisi, Alfonso Mari, Andrea Santoro, Nicola Caprio, Sonia |
| description | AIMS
One‐hour post‐load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1‐hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi‐ethnic cohort of youths with normal glucose tolerance (NGT).
Materials and methods
A total of 202 obese youths with NGT (33.7% Caucasian, 31.1% Hispanic, 32.2% African American) underwent a 3‐hour OGTT at baseline and after a 2‐year follow‐up period. Whole‐body insulin sensitivity, insulin secretion, β‐cell function and insulin clearance were estimated by modeling plasma glucose, insulin and C‐peptide levels.
Results
Obese youths with 1hPG ≥7.4 mmol/L (or 133 mg/dL; n = 83) exhibited higher body mass index (BMI), plasma triglycerides and fasting and post‐load glucose concentrations than individuals with 1hPG |
| doi_str_mv | 10.1111/dom.13640 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179378585</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2207212637</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3880-367d9240cc880480efa153670e18f7b976b538b7f2a2efa96824653cadc154d83</originalsourceid><addsrcrecordid>eNp1kctKxDAUhoMoznhZ-AIScKOLai5tki5lvIIyG12HND11Km0zNikyOx_BZ_RJjHZ0IZhN_px8fBzOQeiAklMaz1np2lPKRUo20JSmgieUM7H5nVmicsImaMf7Z0JIypXcRhNOhOCM0CkK8w4-3t4Xbujx0vkQc-NMiZeN8a3BT81gnQe87KGsbfAxuKcevK9dh4Mb66aAAB7XHTa4HZpQRwmERVdbbN3C9QG7CrsComflhrDwe2irMo2H_fW9ix6vLh9mN8nd_Pp2dn6XWK4USbiQZc5SYm18pYpAZWgWiwSoqmSRS1FkXBWyYobFv1woloqMW1NamqWl4rvoePTGrl8G8EG3tbfQNKYDN3jNqMy5VJnKInr0B32OI-lid5oxIhllgstInYyU7Z33PVR62det6VeaEv21Ch1Xob9XEdnDtXEoWih_yZ_ZR-BsBF7rBlb_m_TF_H5UfgKRZJXi</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2207212637</pqid></control><display><type>article</type><title>One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Tricò, Domenico ; Galderisi, Alfonso ; Mari, Andrea ; Santoro, Nicola ; Caprio, Sonia</creator><creatorcontrib>Tricò, Domenico ; Galderisi, Alfonso ; Mari, Andrea ; Santoro, Nicola ; Caprio, Sonia</creatorcontrib><description>AIMS
One‐hour post‐load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1‐hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi‐ethnic cohort of youths with normal glucose tolerance (NGT).
Materials and methods
A total of 202 obese youths with NGT (33.7% Caucasian, 31.1% Hispanic, 32.2% African American) underwent a 3‐hour OGTT at baseline and after a 2‐year follow‐up period. Whole‐body insulin sensitivity, insulin secretion, β‐cell function and insulin clearance were estimated by modeling plasma glucose, insulin and C‐peptide levels.
Results
Obese youths with 1hPG ≥7.4 mmol/L (or 133 mg/dL; n = 83) exhibited higher body mass index (BMI), plasma triglycerides and fasting and post‐load glucose concentrations than individuals with 1hPG <7.4 mmol/L. Also, 1hPG ≥7.4 mmol/L was associated with a lower disposition index (DI) (P < 0.0001) and with alterations in whole‐body insulin sensitivity, β‐cell function and insulin clearance. Adolescents with 1hPG ≥7.4 mmol/L were approximately three times more likely to develop prediabetes (ie, impaired glucose tolerance and/or impaired fasting glucose) over time (OR, 2.92 [1.22‐6.98]; P = 0.02), independent of age, sex, race/ethnicity, BMI, insulin sensitivity, DI and plasma glucose concentrations. No differences emerged in the risk of prediabetes related to 1‐hour hyperglycaemia among different ethnic groups.
Conclusions
A plasma glucose concentration ≥ 7.4 mmol/L at 1 hour during an OGTT is associated with a worse clinical and metabolic phenotype and may be an independent predictor of progression to prediabetes in obese youths with NGT.</description><identifier>ISSN: 1462-8902</identifier><identifier>EISSN: 1463-1326</identifier><identifier>DOI: 10.1111/dom.13640</identifier><identifier>PMID: 30663201</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adolescents ; Adult ; beta cell function ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Body mass index ; Child ; clinical physiology ; Cohort Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Disease Progression ; Ethnic Groups - statistics & numerical data ; Fasting ; Female ; Glucose ; Glucose - pharmacology ; Glucose Intolerance - blood ; Glucose Intolerance - diagnosis ; Glucose Intolerance - ethnology ; Glucose Intolerance - pathology ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Hyperglycemia ; Insulin ; Insulin Resistance ; Insulin secretion ; Laboratory testing ; Longitudinal Studies ; Male ; Minority & ethnic groups ; Obesity ; Obesity - blood ; Obesity - complications ; Obesity - diagnosis ; Obesity - ethnology ; Phenotypes ; Plasma ; Prediabetic State - blood ; Prediabetic State - complications ; Prediabetic State - diagnosis ; Prediabetic State - ethnology ; Prognosis ; Retrospective Studies ; Secretion ; Time Factors ; Triglycerides ; type 2 diabetes ; Young Adult</subject><ispartof>Diabetes, obesity & metabolism, 2019-05, Vol.21 (5), p.1191-1198</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-367d9240cc880480efa153670e18f7b976b538b7f2a2efa96824653cadc154d83</citedby><cites>FETCH-LOGICAL-c3880-367d9240cc880480efa153670e18f7b976b538b7f2a2efa96824653cadc154d83</cites><orcidid>0000-0002-7633-1346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fdom.13640$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fdom.13640$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30663201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tricò, Domenico</creatorcontrib><creatorcontrib>Galderisi, Alfonso</creatorcontrib><creatorcontrib>Mari, Andrea</creatorcontrib><creatorcontrib>Santoro, Nicola</creatorcontrib><creatorcontrib>Caprio, Sonia</creatorcontrib><title>One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths</title><title>Diabetes, obesity & metabolism</title><addtitle>Diabetes Obes Metab</addtitle><description>AIMS
One‐hour post‐load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1‐hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi‐ethnic cohort of youths with normal glucose tolerance (NGT).
Materials and methods
A total of 202 obese youths with NGT (33.7% Caucasian, 31.1% Hispanic, 32.2% African American) underwent a 3‐hour OGTT at baseline and after a 2‐year follow‐up period. Whole‐body insulin sensitivity, insulin secretion, β‐cell function and insulin clearance were estimated by modeling plasma glucose, insulin and C‐peptide levels.
Results
Obese youths with 1hPG ≥7.4 mmol/L (or 133 mg/dL; n = 83) exhibited higher body mass index (BMI), plasma triglycerides and fasting and post‐load glucose concentrations than individuals with 1hPG <7.4 mmol/L. Also, 1hPG ≥7.4 mmol/L was associated with a lower disposition index (DI) (P < 0.0001) and with alterations in whole‐body insulin sensitivity, β‐cell function and insulin clearance. Adolescents with 1hPG ≥7.4 mmol/L were approximately three times more likely to develop prediabetes (ie, impaired glucose tolerance and/or impaired fasting glucose) over time (OR, 2.92 [1.22‐6.98]; P = 0.02), independent of age, sex, race/ethnicity, BMI, insulin sensitivity, DI and plasma glucose concentrations. No differences emerged in the risk of prediabetes related to 1‐hour hyperglycaemia among different ethnic groups.
Conclusions
A plasma glucose concentration ≥ 7.4 mmol/L at 1 hour during an OGTT is associated with a worse clinical and metabolic phenotype and may be an independent predictor of progression to prediabetes in obese youths with NGT.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>beta cell function</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Body mass index</subject><subject>Child</subject><subject>clinical physiology</subject><subject>Cohort Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Disease Progression</subject><subject>Ethnic Groups - statistics & numerical data</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose - pharmacology</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Intolerance - diagnosis</subject><subject>Glucose Intolerance - ethnology</subject><subject>Glucose Intolerance - pathology</subject><subject>Glucose tolerance</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Hyperglycemia</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Insulin secretion</subject><subject>Laboratory testing</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Minority & ethnic groups</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - complications</subject><subject>Obesity - diagnosis</subject><subject>Obesity - ethnology</subject><subject>Phenotypes</subject><subject>Plasma</subject><subject>Prediabetic State - blood</subject><subject>Prediabetic State - complications</subject><subject>Prediabetic State - diagnosis</subject><subject>Prediabetic State - ethnology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Secretion</subject><subject>Time Factors</subject><subject>Triglycerides</subject><subject>type 2 diabetes</subject><subject>Young Adult</subject><issn>1462-8902</issn><issn>1463-1326</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMoznhZ-AIScKOLai5tki5lvIIyG12HND11Km0zNikyOx_BZ_RJjHZ0IZhN_px8fBzOQeiAklMaz1np2lPKRUo20JSmgieUM7H5nVmicsImaMf7Z0JIypXcRhNOhOCM0CkK8w4-3t4Xbujx0vkQc-NMiZeN8a3BT81gnQe87KGsbfAxuKcevK9dh4Mb66aAAB7XHTa4HZpQRwmERVdbbN3C9QG7CrsComflhrDwe2irMo2H_fW9ix6vLh9mN8nd_Pp2dn6XWK4USbiQZc5SYm18pYpAZWgWiwSoqmSRS1FkXBWyYobFv1woloqMW1NamqWl4rvoePTGrl8G8EG3tbfQNKYDN3jNqMy5VJnKInr0B32OI-lid5oxIhllgstInYyU7Z33PVR62det6VeaEv21Ch1Xob9XEdnDtXEoWih_yZ_ZR-BsBF7rBlb_m_TF_H5UfgKRZJXi</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Tricò, Domenico</creator><creator>Galderisi, Alfonso</creator><creator>Mari, Andrea</creator><creator>Santoro, Nicola</creator><creator>Caprio, Sonia</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7633-1346</orcidid></search><sort><creationdate>201905</creationdate><title>One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths</title><author>Tricò, Domenico ; Galderisi, Alfonso ; Mari, Andrea ; Santoro, Nicola ; Caprio, Sonia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-367d9240cc880480efa153670e18f7b976b538b7f2a2efa96824653cadc154d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>beta cell function</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - metabolism</topic><topic>Body mass index</topic><topic>Child</topic><topic>clinical physiology</topic><topic>Cohort Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Disease Progression</topic><topic>Ethnic Groups - statistics & numerical data</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose - pharmacology</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Intolerance - diagnosis</topic><topic>Glucose Intolerance - ethnology</topic><topic>Glucose Intolerance - pathology</topic><topic>Glucose tolerance</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Hyperglycemia</topic><topic>Insulin</topic><topic>Insulin Resistance</topic><topic>Insulin secretion</topic><topic>Laboratory testing</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Minority & ethnic groups</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - complications</topic><topic>Obesity - diagnosis</topic><topic>Obesity - ethnology</topic><topic>Phenotypes</topic><topic>Plasma</topic><topic>Prediabetic State - blood</topic><topic>Prediabetic State - complications</topic><topic>Prediabetic State - diagnosis</topic><topic>Prediabetic State - ethnology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Secretion</topic><topic>Time Factors</topic><topic>Triglycerides</topic><topic>type 2 diabetes</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tricò, Domenico</creatorcontrib><creatorcontrib>Galderisi, Alfonso</creatorcontrib><creatorcontrib>Mari, Andrea</creatorcontrib><creatorcontrib>Santoro, Nicola</creatorcontrib><creatorcontrib>Caprio, Sonia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes, obesity & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tricò, Domenico</au><au>Galderisi, Alfonso</au><au>Mari, Andrea</au><au>Santoro, Nicola</au><au>Caprio, Sonia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths</atitle><jtitle>Diabetes, obesity & metabolism</jtitle><addtitle>Diabetes Obes Metab</addtitle><date>2019-05</date><risdate>2019</risdate><volume>21</volume><issue>5</issue><spage>1191</spage><epage>1198</epage><pages>1191-1198</pages><issn>1462-8902</issn><eissn>1463-1326</eissn><abstract>AIMS
One‐hour post‐load hyperglycaemia has been proposed as an independent predictor of type 2 diabetes in adults. We examined whether 1‐hour plasma glucose (1hPG) during an oral glucose tolerance test (OGTT) can predict changes in the glucose tolerance status of a multi‐ethnic cohort of youths with normal glucose tolerance (NGT).
Materials and methods
A total of 202 obese youths with NGT (33.7% Caucasian, 31.1% Hispanic, 32.2% African American) underwent a 3‐hour OGTT at baseline and after a 2‐year follow‐up period. Whole‐body insulin sensitivity, insulin secretion, β‐cell function and insulin clearance were estimated by modeling plasma glucose, insulin and C‐peptide levels.
Results
Obese youths with 1hPG ≥7.4 mmol/L (or 133 mg/dL; n = 83) exhibited higher body mass index (BMI), plasma triglycerides and fasting and post‐load glucose concentrations than individuals with 1hPG <7.4 mmol/L. Also, 1hPG ≥7.4 mmol/L was associated with a lower disposition index (DI) (P < 0.0001) and with alterations in whole‐body insulin sensitivity, β‐cell function and insulin clearance. Adolescents with 1hPG ≥7.4 mmol/L were approximately three times more likely to develop prediabetes (ie, impaired glucose tolerance and/or impaired fasting glucose) over time (OR, 2.92 [1.22‐6.98]; P = 0.02), independent of age, sex, race/ethnicity, BMI, insulin sensitivity, DI and plasma glucose concentrations. No differences emerged in the risk of prediabetes related to 1‐hour hyperglycaemia among different ethnic groups.
Conclusions
A plasma glucose concentration ≥ 7.4 mmol/L at 1 hour during an OGTT is associated with a worse clinical and metabolic phenotype and may be an independent predictor of progression to prediabetes in obese youths with NGT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>30663201</pmid><doi>10.1111/dom.13640</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7633-1346</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adolescents Adult beta cell function Blood Glucose - analysis Blood Glucose - metabolism Body mass index Child clinical physiology Cohort Studies Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Disease Progression Ethnic Groups - statistics & numerical data Fasting Female Glucose Glucose - pharmacology Glucose Intolerance - blood Glucose Intolerance - diagnosis Glucose Intolerance - ethnology Glucose Intolerance - pathology Glucose tolerance Glucose Tolerance Test Humans Hyperglycemia Insulin Insulin Resistance Insulin secretion Laboratory testing Longitudinal Studies Male Minority & ethnic groups Obesity Obesity - blood Obesity - complications Obesity - diagnosis Obesity - ethnology Phenotypes Plasma Prediabetic State - blood Prediabetic State - complications Prediabetic State - diagnosis Prediabetic State - ethnology Prognosis Retrospective Studies Secretion Time Factors Triglycerides type 2 diabetes Young Adult |
| title | One‐hour post‐load plasma glucose predicts progression to prediabetes in a multi‐ethnic cohort of obese youths |
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