Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification
Structured Objectives To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats. Setting and Sample Population Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats...
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| Veröffentlicht in: | Orthodontics & craniofacial research 2019-05, Vol.22 (2), p.112-117 |
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| container_title | Orthodontics & craniofacial research |
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| creator | Tsai, Chi Yang Wang, Chun‐Wei Chang, Chiung‐Wen |
| description | Structured
Objectives
To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats.
Setting and Sample Population
Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles.
Material & Methods
Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance.
Results
No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX‐injected group.
Conclusions
Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth. |
| doi_str_mv | 10.1111/ocr.12290 |
| format | Article |
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Objectives
To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats.
Setting and Sample Population
Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles.
Material & Methods
Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance.
Results
No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX‐injected group.
Conclusions
Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth.</description><identifier>ISSN: 1601-6335</identifier><identifier>EISSN: 1601-6343</identifier><identifier>DOI: 10.1111/ocr.12290</identifier><identifier>PMID: 30657256</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Apposition ; Body weight ; Bone density ; Bone growth ; Bone mineral density ; Botulinum toxin ; Botulinum toxin type A ; Craniofacial growth ; Dentistry ; Masseter muscle ; Mastication ; masticatory muscle hypofunction ; Muscle function ; Muscles ; Orthodontics ; suture bone growth ; Temporalis muscle</subject><ispartof>Orthodontics & craniofacial research, 2019-05, Vol.22 (2), p.112-117</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4190-e75c84a32671eff20bb88f568d81ac17a7b4c507193ce8d16b07cf77e29d3e4e3</citedby><cites>FETCH-LOGICAL-c4190-e75c84a32671eff20bb88f568d81ac17a7b4c507193ce8d16b07cf77e29d3e4e3</cites><orcidid>0000-0002-5563-4292</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Focr.12290$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Focr.12290$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30657256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tsai, Chi Yang</creatorcontrib><creatorcontrib>Wang, Chun‐Wei</creatorcontrib><creatorcontrib>Chang, Chiung‐Wen</creatorcontrib><title>Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification</title><title>Orthodontics & craniofacial research</title><addtitle>Orthod Craniofac Res</addtitle><description>Structured
Objectives
To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats.
Setting and Sample Population
Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles.
Material & Methods
Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance.
Results
No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX‐injected group.
Conclusions
Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth.</description><subject>Apposition</subject><subject>Body weight</subject><subject>Bone density</subject><subject>Bone growth</subject><subject>Bone mineral density</subject><subject>Botulinum toxin</subject><subject>Botulinum toxin type A</subject><subject>Craniofacial growth</subject><subject>Dentistry</subject><subject>Masseter muscle</subject><subject>Mastication</subject><subject>masticatory muscle hypofunction</subject><subject>Muscle function</subject><subject>Muscles</subject><subject>Orthodontics</subject><subject>suture bone growth</subject><subject>Temporalis muscle</subject><issn>1601-6335</issn><issn>1601-6343</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kctKxDAUhoMo3he-gATc6GKcXNqkXergDYQBUXAX0vREK22juaDz9mYcdSGYzQnJx8fh_xE6oOSU5jN1xp9SxmqyhrapIHQieMHXf--83EI7IbwQwghjYhNtcSJKyUqxjeKFtWBiwM7iQYfYGR2dX-AhBdMDtmk0sXMj1l8YtLhZ4PP7R5yfBv3R9b2z2nS6x40bAT959x6fcXz2Lj0tJ-CQYvL5f3BtZ5f2bNtDG1b3Afa_5y56uLy4n11PbudXN7Oz24kpaE0mIEtTFZozISlYy0jTVJUtRdVWVBsqtWwKUxJJa26gaqloiDRWSmB1y6EAvouOV95X794ShKiGLhjoez2CS0ExKmsuqRQko0d_0BeX_Ji3UyynJuscnMzUyYoy3oXgwapX3w3aLxQlalmFylWoryoye_htTM0A7S_5k30Gpivgveth8b9JzWd3K-UnjzyTqw</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Tsai, Chi Yang</creator><creator>Wang, Chun‐Wei</creator><creator>Chang, Chiung‐Wen</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5563-4292</orcidid></search><sort><creationdate>201905</creationdate><title>Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification</title><author>Tsai, Chi Yang ; Wang, Chun‐Wei ; Chang, Chiung‐Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4190-e75c84a32671eff20bb88f568d81ac17a7b4c507193ce8d16b07cf77e29d3e4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Apposition</topic><topic>Body weight</topic><topic>Bone density</topic><topic>Bone growth</topic><topic>Bone mineral density</topic><topic>Botulinum toxin</topic><topic>Botulinum toxin type A</topic><topic>Craniofacial growth</topic><topic>Dentistry</topic><topic>Masseter muscle</topic><topic>Mastication</topic><topic>masticatory muscle hypofunction</topic><topic>Muscle function</topic><topic>Muscles</topic><topic>Orthodontics</topic><topic>suture bone growth</topic><topic>Temporalis muscle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsai, Chi Yang</creatorcontrib><creatorcontrib>Wang, Chun‐Wei</creatorcontrib><creatorcontrib>Chang, Chiung‐Wen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Orthodontics & craniofacial research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsai, Chi Yang</au><au>Wang, Chun‐Wei</au><au>Chang, Chiung‐Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification</atitle><jtitle>Orthodontics & craniofacial research</jtitle><addtitle>Orthod Craniofac Res</addtitle><date>2019-05</date><risdate>2019</risdate><volume>22</volume><issue>2</issue><spage>112</spage><epage>117</epage><pages>112-117</pages><issn>1601-6335</issn><eissn>1601-6343</eissn><abstract>Structured
Objectives
To evaluate the effect of botulinum toxin type A (BTX)‐induced masticatory muscle hypofunction on the maxillofacial suture bone growth of growing rats.
Setting and Sample Population
Department of Orthodontics at Taipei Medical University. Forty‐eight male 4‐week‐old Wistar rats were divided into four groups. The N group received injections of normal saline into each of the masseter and temporalis muscles. The M group received injections of normal saline into each of the temporalis muscle and injections of BTX into each of the masseter muscle. The T group received injections of normal saline into each of the masseter muscle and injections of BTX into each of the temporalis muscle. The MT group received injections of BTX into each of the masseter and temporalis muscles.
Material & Methods
Rats were sacrificed after 42 days of growth. Changes in body and muscle weight were measured. Anthropometric measurements of the maxillary arch, sutural bone mineral density and sutural bone deposition distances were recorded. Statistical comparisons were performed using analysis of variance.
Results
No significant change in body weight was found across groups. However, significant decreases were observed in muscle weight, anthropometric measurements, sutural bone mineral density and bone apposition distance in the BTX‐injected group.
Conclusions
Reduced masticatory muscle function in growing rats can affect maxillofacial suture bone growth.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30657256</pmid><doi>10.1111/ocr.12290</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5563-4292</orcidid></addata></record> |
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| ispartof | Orthodontics & craniofacial research, 2019-05, Vol.22 (2), p.112-117 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2179371760 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Apposition Body weight Bone density Bone growth Bone mineral density Botulinum toxin Botulinum toxin type A Craniofacial growth Dentistry Masseter muscle Mastication masticatory muscle hypofunction Muscle function Muscles Orthodontics suture bone growth Temporalis muscle |
| title | Effects of masticatory muscle function affected by BTX on maxillofacial bone growth through the sutural modification |
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