Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping
Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation. The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping. We...
Gespeichert in:
| Veröffentlicht in: | Heart rhythm 2019-02, Vol.16 (2), p.251-259 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 259 |
|---|---|
| container_issue | 2 |
| container_start_page | 251 |
| container_title | Heart rhythm |
| container_volume | 16 |
| creator | Voskoboinik, Aleksandr Wong, Geoffrey Lee, Geoff Nalliah, Chrishan Hawson, Joshua Prabhu, Sandeep Sugumar, Hariharan Ling, Liang-Han McLellan, Alex Morton, Joseph Kalman, Jonathan M. Kistler, Peter M. |
| description | Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation.
The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping.
We enrolled 75 patients before AF ablation to undergo high-density LA mapping (CARTO, Biosense Webster) using a multipolar catheter. The Confidense algorithm was used to create maps during distal coronary sinus pacing at 600 ms. Bipolar voltage and complex atrial activity were assessed, and isochronal activation maps were created to determine global conduction velocity (CV). Patients were classified as lifelong nondrinkers, mild drinkers (2–7 drinks/week), or moderate drinkers (8–21 drinks/week).
High-density electroanatomic mapping (mean 1016 ± 445 points per patient) was performed on 25 lifelong nondrinkers, 25 mild drinkers (4.4 ± 2.3 drinks/week), and 25 moderate drinkers (14.0 ± 4.2 drinks/week). Moderate drinkers had significantly lower mean global bipolar voltages (1.53 ± 0.62 mV vs 1.89 ± 0.45 mV; P = .02), slower CV (33.5 ± 14.4 cm/s vs 41.7 ± 12.1 cm/s; P = .04), and a higher proportion of complex atrial potentials (7.8% ± 4.7% vs 4.5% ± 2.7%; P = .004) compared to nondrinkers. Global voltage and CV did not differ significantly in mild drinkers, but there was a significant increase in global complex potentials (6.6% ± 4.6%; P = .04) and regional low-voltage zones ( |
| doi_str_mv | 10.1016/j.hrthm.2018.10.041 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179368818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1547527118311317</els_id><sourcerecordid>2179368818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-75a7f8722abffdba6ecd9e31b1605f7923b97b7629b4aead371a6b105a7677943</originalsourceid><addsrcrecordid>eNp9kc2OFCEUhYnROOPoE5gYlm6qhaILChMXZuLPJGPc6JrcgltddKqgBEozb-LjStujiRtXHE6-c2_gEPKcsx1nXL467qZUpmXXMt5XZ8f2_AG55F0nG9Er_vCk96rpWsUvyJOcj4y1WjLxmFwIJoVmil2Sn5-iwwQFKcw2TnGmNoa8LWvxMVCfKeQcra-Aoz98mSiU5GGmOKOtylYJwdFc0mbLlurVThAOmF_Tm5D9YSqZjikudKq6cVi9ckdnHMu_kyIEKHHxli6wrj4cnpJHI8wZn92fV-Tr-3dfrj82t58_3Fy_vW2s6HRpVAdq7FXbwjCObgCJ1mkUfOCSdaPSrRi0GpRs9bAHBCcUBzlwVmNSKb0XV-Tlee6a4rcNczGLzxbnGQLGLZuWKy1k3_O-ouKM2hRzTjiaNfkF0p3hzJwqMUfzuxJzquRk1kpq6sX9gm1Y0P3N_OmgAm_OANZnfveYTLYeg0XnU_0a46L_74JftOuinQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179368818</pqid></control><display><type>article</type><title>Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping</title><source>Elsevier ScienceDirect Journals</source><creator>Voskoboinik, Aleksandr ; Wong, Geoffrey ; Lee, Geoff ; Nalliah, Chrishan ; Hawson, Joshua ; Prabhu, Sandeep ; Sugumar, Hariharan ; Ling, Liang-Han ; McLellan, Alex ; Morton, Joseph ; Kalman, Jonathan M. ; Kistler, Peter M.</creator><creatorcontrib>Voskoboinik, Aleksandr ; Wong, Geoffrey ; Lee, Geoff ; Nalliah, Chrishan ; Hawson, Joshua ; Prabhu, Sandeep ; Sugumar, Hariharan ; Ling, Liang-Han ; McLellan, Alex ; Morton, Joseph ; Kalman, Jonathan M. ; Kistler, Peter M.</creatorcontrib><description>Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation.
The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping.
We enrolled 75 patients before AF ablation to undergo high-density LA mapping (CARTO, Biosense Webster) using a multipolar catheter. The Confidense algorithm was used to create maps during distal coronary sinus pacing at 600 ms. Bipolar voltage and complex atrial activity were assessed, and isochronal activation maps were created to determine global conduction velocity (CV). Patients were classified as lifelong nondrinkers, mild drinkers (2–7 drinks/week), or moderate drinkers (8–21 drinks/week).
High-density electroanatomic mapping (mean 1016 ± 445 points per patient) was performed on 25 lifelong nondrinkers, 25 mild drinkers (4.4 ± 2.3 drinks/week), and 25 moderate drinkers (14.0 ± 4.2 drinks/week). Moderate drinkers had significantly lower mean global bipolar voltages (1.53 ± 0.62 mV vs 1.89 ± 0.45 mV; P = .02), slower CV (33.5 ± 14.4 cm/s vs 41.7 ± 12.1 cm/s; P = .04), and a higher proportion of complex atrial potentials (7.8% ± 4.7% vs 4.5% ± 2.7%; P = .004) compared to nondrinkers. Global voltage and CV did not differ significantly in mild drinkers, but there was a significant increase in global complex potentials (6.6% ± 4.6%; P = .04) and regional low-voltage zones (<0.5 mV) in the septum and lateral wall (P <.05) compared with nondrinkers.
Regular moderate alcohol consumption, but not mild consumption, is an important modifiable risk factor for AF associated with lower atrial voltage and conduction slowing. These electrical and structural changes may explain the propensity to AF in regular drinkers.</description><identifier>ISSN: 1547-5271</identifier><identifier>EISSN: 1556-3871</identifier><identifier>DOI: 10.1016/j.hrthm.2018.10.041</identifier><identifier>PMID: 30639070</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alcohol ; Atrial fibrillation ; Atrial substrate ; Conduction velocity ; Electroanatomic mapping ; Left atrium ; Voltage</subject><ispartof>Heart rhythm, 2019-02, Vol.16 (2), p.251-259</ispartof><rights>2018 Heart Rhythm Society</rights><rights>Copyright © 2018 Heart Rhythm Society. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-75a7f8722abffdba6ecd9e31b1605f7923b97b7629b4aead371a6b105a7677943</citedby><cites>FETCH-LOGICAL-c359t-75a7f8722abffdba6ecd9e31b1605f7923b97b7629b4aead371a6b105a7677943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1547527118311317$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30639070$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voskoboinik, Aleksandr</creatorcontrib><creatorcontrib>Wong, Geoffrey</creatorcontrib><creatorcontrib>Lee, Geoff</creatorcontrib><creatorcontrib>Nalliah, Chrishan</creatorcontrib><creatorcontrib>Hawson, Joshua</creatorcontrib><creatorcontrib>Prabhu, Sandeep</creatorcontrib><creatorcontrib>Sugumar, Hariharan</creatorcontrib><creatorcontrib>Ling, Liang-Han</creatorcontrib><creatorcontrib>McLellan, Alex</creatorcontrib><creatorcontrib>Morton, Joseph</creatorcontrib><creatorcontrib>Kalman, Jonathan M.</creatorcontrib><creatorcontrib>Kistler, Peter M.</creatorcontrib><title>Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping</title><title>Heart rhythm</title><addtitle>Heart Rhythm</addtitle><description>Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation.
The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping.
We enrolled 75 patients before AF ablation to undergo high-density LA mapping (CARTO, Biosense Webster) using a multipolar catheter. The Confidense algorithm was used to create maps during distal coronary sinus pacing at 600 ms. Bipolar voltage and complex atrial activity were assessed, and isochronal activation maps were created to determine global conduction velocity (CV). Patients were classified as lifelong nondrinkers, mild drinkers (2–7 drinks/week), or moderate drinkers (8–21 drinks/week).
High-density electroanatomic mapping (mean 1016 ± 445 points per patient) was performed on 25 lifelong nondrinkers, 25 mild drinkers (4.4 ± 2.3 drinks/week), and 25 moderate drinkers (14.0 ± 4.2 drinks/week). Moderate drinkers had significantly lower mean global bipolar voltages (1.53 ± 0.62 mV vs 1.89 ± 0.45 mV; P = .02), slower CV (33.5 ± 14.4 cm/s vs 41.7 ± 12.1 cm/s; P = .04), and a higher proportion of complex atrial potentials (7.8% ± 4.7% vs 4.5% ± 2.7%; P = .004) compared to nondrinkers. Global voltage and CV did not differ significantly in mild drinkers, but there was a significant increase in global complex potentials (6.6% ± 4.6%; P = .04) and regional low-voltage zones (<0.5 mV) in the septum and lateral wall (P <.05) compared with nondrinkers.
Regular moderate alcohol consumption, but not mild consumption, is an important modifiable risk factor for AF associated with lower atrial voltage and conduction slowing. These electrical and structural changes may explain the propensity to AF in regular drinkers.</description><subject>Alcohol</subject><subject>Atrial fibrillation</subject><subject>Atrial substrate</subject><subject>Conduction velocity</subject><subject>Electroanatomic mapping</subject><subject>Left atrium</subject><subject>Voltage</subject><issn>1547-5271</issn><issn>1556-3871</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc2OFCEUhYnROOPoE5gYlm6qhaILChMXZuLPJGPc6JrcgltddKqgBEozb-LjStujiRtXHE6-c2_gEPKcsx1nXL467qZUpmXXMt5XZ8f2_AG55F0nG9Er_vCk96rpWsUvyJOcj4y1WjLxmFwIJoVmil2Sn5-iwwQFKcw2TnGmNoa8LWvxMVCfKeQcra-Aoz98mSiU5GGmOKOtylYJwdFc0mbLlurVThAOmF_Tm5D9YSqZjikudKq6cVi9ckdnHMu_kyIEKHHxli6wrj4cnpJHI8wZn92fV-Tr-3dfrj82t58_3Fy_vW2s6HRpVAdq7FXbwjCObgCJ1mkUfOCSdaPSrRi0GpRs9bAHBCcUBzlwVmNSKb0XV-Tlee6a4rcNczGLzxbnGQLGLZuWKy1k3_O-ouKM2hRzTjiaNfkF0p3hzJwqMUfzuxJzquRk1kpq6sX9gm1Y0P3N_OmgAm_OANZnfveYTLYeg0XnU_0a46L_74JftOuinQ</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Voskoboinik, Aleksandr</creator><creator>Wong, Geoffrey</creator><creator>Lee, Geoff</creator><creator>Nalliah, Chrishan</creator><creator>Hawson, Joshua</creator><creator>Prabhu, Sandeep</creator><creator>Sugumar, Hariharan</creator><creator>Ling, Liang-Han</creator><creator>McLellan, Alex</creator><creator>Morton, Joseph</creator><creator>Kalman, Jonathan M.</creator><creator>Kistler, Peter M.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201902</creationdate><title>Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping</title><author>Voskoboinik, Aleksandr ; Wong, Geoffrey ; Lee, Geoff ; Nalliah, Chrishan ; Hawson, Joshua ; Prabhu, Sandeep ; Sugumar, Hariharan ; Ling, Liang-Han ; McLellan, Alex ; Morton, Joseph ; Kalman, Jonathan M. ; Kistler, Peter M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-75a7f8722abffdba6ecd9e31b1605f7923b97b7629b4aead371a6b105a7677943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcohol</topic><topic>Atrial fibrillation</topic><topic>Atrial substrate</topic><topic>Conduction velocity</topic><topic>Electroanatomic mapping</topic><topic>Left atrium</topic><topic>Voltage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voskoboinik, Aleksandr</creatorcontrib><creatorcontrib>Wong, Geoffrey</creatorcontrib><creatorcontrib>Lee, Geoff</creatorcontrib><creatorcontrib>Nalliah, Chrishan</creatorcontrib><creatorcontrib>Hawson, Joshua</creatorcontrib><creatorcontrib>Prabhu, Sandeep</creatorcontrib><creatorcontrib>Sugumar, Hariharan</creatorcontrib><creatorcontrib>Ling, Liang-Han</creatorcontrib><creatorcontrib>McLellan, Alex</creatorcontrib><creatorcontrib>Morton, Joseph</creatorcontrib><creatorcontrib>Kalman, Jonathan M.</creatorcontrib><creatorcontrib>Kistler, Peter M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Heart rhythm</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voskoboinik, Aleksandr</au><au>Wong, Geoffrey</au><au>Lee, Geoff</au><au>Nalliah, Chrishan</au><au>Hawson, Joshua</au><au>Prabhu, Sandeep</au><au>Sugumar, Hariharan</au><au>Ling, Liang-Han</au><au>McLellan, Alex</au><au>Morton, Joseph</au><au>Kalman, Jonathan M.</au><au>Kistler, Peter M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping</atitle><jtitle>Heart rhythm</jtitle><addtitle>Heart Rhythm</addtitle><date>2019-02</date><risdate>2019</risdate><volume>16</volume><issue>2</issue><spage>251</spage><epage>259</epage><pages>251-259</pages><issn>1547-5271</issn><eissn>1556-3871</eissn><abstract>Regular alcohol intake is an important modifiable risk factor associated with atrial fibrillation (AF) and left atrial (LA) dilation.
The purpose of this study was to determine the impact of different degrees of alcohol consumption on atrial remodeling using high-density electroanatomic mapping.
We enrolled 75 patients before AF ablation to undergo high-density LA mapping (CARTO, Biosense Webster) using a multipolar catheter. The Confidense algorithm was used to create maps during distal coronary sinus pacing at 600 ms. Bipolar voltage and complex atrial activity were assessed, and isochronal activation maps were created to determine global conduction velocity (CV). Patients were classified as lifelong nondrinkers, mild drinkers (2–7 drinks/week), or moderate drinkers (8–21 drinks/week).
High-density electroanatomic mapping (mean 1016 ± 445 points per patient) was performed on 25 lifelong nondrinkers, 25 mild drinkers (4.4 ± 2.3 drinks/week), and 25 moderate drinkers (14.0 ± 4.2 drinks/week). Moderate drinkers had significantly lower mean global bipolar voltages (1.53 ± 0.62 mV vs 1.89 ± 0.45 mV; P = .02), slower CV (33.5 ± 14.4 cm/s vs 41.7 ± 12.1 cm/s; P = .04), and a higher proportion of complex atrial potentials (7.8% ± 4.7% vs 4.5% ± 2.7%; P = .004) compared to nondrinkers. Global voltage and CV did not differ significantly in mild drinkers, but there was a significant increase in global complex potentials (6.6% ± 4.6%; P = .04) and regional low-voltage zones (<0.5 mV) in the septum and lateral wall (P <.05) compared with nondrinkers.
Regular moderate alcohol consumption, but not mild consumption, is an important modifiable risk factor for AF associated with lower atrial voltage and conduction slowing. These electrical and structural changes may explain the propensity to AF in regular drinkers.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30639070</pmid><doi>10.1016/j.hrthm.2018.10.041</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1547-5271 |
| ispartof | Heart rhythm, 2019-02, Vol.16 (2), p.251-259 |
| issn | 1547-5271 1556-3871 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179368818 |
| source | Elsevier ScienceDirect Journals |
| subjects | Alcohol Atrial fibrillation Atrial substrate Conduction velocity Electroanatomic mapping Left atrium Voltage |
| title | Moderate alcohol consumption is associated with atrial electrical and structural changes: Insights from high-density left atrial electroanatomic mapping |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T05%3A26%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Moderate%20alcohol%20consumption%20is%20associated%20with%20atrial%20electrical%20and%20structural%20changes:%20Insights%20from%20high-density%20left%20atrial%20electroanatomic%20mapping&rft.jtitle=Heart%20rhythm&rft.au=Voskoboinik,%20Aleksandr&rft.date=2019-02&rft.volume=16&rft.issue=2&rft.spage=251&rft.epage=259&rft.pages=251-259&rft.issn=1547-5271&rft.eissn=1556-3871&rft_id=info:doi/10.1016/j.hrthm.2018.10.041&rft_dat=%3Cproquest_cross%3E2179368818%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2179368818&rft_id=info:pmid/30639070&rft_els_id=S1547527118311317&rfr_iscdi=true |