Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects
Background Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a...
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| Veröffentlicht in: | International Journal of Obesity 2020-01, Vol.44 (1), p.159-166 |
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| creator | Sapunar, Jorge Fonseca, Luis Molina, Víctor Ortiz, Eugenia Barra, Maria Ines Reimer, Camila Charles, Maria Schneider, Constance Ortiz, Manuel Brito, Roberto Manríquez, Víctor Pavez, Monica Cerda, Alvaro |
| description | Background
Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population.
Subjects and methods
Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5–24.9 kg/m
2
) and 151 obese (BMI > 30 kg/m
2
) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay.
Results
Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58–4.51,
p
|
| doi_str_mv | 10.1038/s41366-019-0321-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179366780</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A609283594</galeid><sourcerecordid>A609283594</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-d0ca8c2b8a1aee08696d55f3483956a098c77b141bc0eb03e406b900e8c447603</originalsourceid><addsrcrecordid>eNp1kl-PEyEUxSdG43ZXP4AvhsTE7MPOehkGhnlsGv8lm_iiz4RhblsqhQpMk357mXTVXaPh4RL4nRvu4VTVKwq3FJh8l1rKhKiB9jWwhtbtk2pB207UvO27p9UCGHQ1cMEvqsuUdgDAOTTPqwsGgvcNl4vqsBzRh6ONUyJMkIQxHEKy2R5tPhGbSESnM44kBxIGTPNptOn7Ddm4k8G9NcQEn2NwN0T7kTg8ZOtLOaJLpOxWW-tQe5KmYYcmpxfVs7V2CV_e16vq24f3X1ef6rsvHz-vlne1aTvI9QhGS9MMUlONCFL0YuR8zVrJei409NJ03UBbOhjAARi2IIYeAKVpiwPArqrrc99DDD8mTFntbTLonPYYpqQa2vXFvE7O6Ju_0F2Yoi-vUw1rZEehEQ-ojXaorF-HHLWZm6qlgL6RjPdtoW7_QZU1zl4Fj-tix2PB2weCLWqXtym4Kdvg02OQnkETQ0oR1-oQ7V7Hk6Kg5jiocxxUiYOa46Bmzev7yaZhj-Nvxa__L0BzBlK58huMf0b_f9efW8K9LQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2328710260</pqid></control><display><type>article</type><title>Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Sapunar, Jorge ; Fonseca, Luis ; Molina, Víctor ; Ortiz, Eugenia ; Barra, Maria Ines ; Reimer, Camila ; Charles, Maria ; Schneider, Constance ; Ortiz, Manuel ; Brito, Roberto ; Manríquez, Víctor ; Pavez, Monica ; Cerda, Alvaro</creator><creatorcontrib>Sapunar, Jorge ; Fonseca, Luis ; Molina, Víctor ; Ortiz, Eugenia ; Barra, Maria Ines ; Reimer, Camila ; Charles, Maria ; Schneider, Constance ; Ortiz, Manuel ; Brito, Roberto ; Manríquez, Víctor ; Pavez, Monica ; Cerda, Alvaro</creatorcontrib><description>Background
Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population.
Subjects and methods
Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5–24.9 kg/m
2
) and 151 obese (BMI > 30 kg/m
2
) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay.
Results
Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58–4.51,
p
< 0.001). Interestingly, Ad-36 was related to lower concentrations of triglycerides and VLDL cholesterol in lean subjects (
p
= 0.049) and lower leptin in obese individuals (
p
= 0.014). Previous Ad-36 infection was also related to lower glycemia, insulinemia, and HOMA-IR (
p
< 0.05) in obese subjects who were not under antidiabetic drugs.
Conclusions
Our results provide evidence of the contribution of previous Ad-36 infection to an increased risk of obesity in adult Chilean population. Ad-36 seropositivity was also associated to lipid profile, glycemic control, and leptin levels in adult Chilean population.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-019-0321-4</identifier><identifier>PMID: 30659258</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/163/2743/393 ; 692/499 ; 82/1 ; 82/80 ; Adenoviridae - immunology ; Adenoviridae Infections - complications ; Adenoviridae Infections - epidemiology ; Adenoviridae Infections - immunology ; Adenovirus ; Adenoviruses ; Adiponectin ; Adipose tissue ; Adult ; Advertising executives ; Anthropometry ; Antibodies, Viral - blood ; Antidiabetics ; Blood glucose ; Blood Glucose - analysis ; Case-Control Studies ; Children ; Chile ; Cholesterol ; Dextrose ; Diabetes mellitus ; Diabetes therapy ; Enzyme-linked immunosorbent assay ; Enzymes ; Epidemiology ; Female ; Glucose ; Health aspects ; Health Promotion and Disease Prevention ; Health risk assessment ; Humans ; Hypoglycemic agents ; Insulin ; Internal Medicine ; Laboratory tests ; Leptin ; Leptin - blood ; Lipids ; Lipoproteins (very low density) ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Obesity ; Obesity - complications ; Obesity - epidemiology ; Population ; Population studies ; Public Health ; Risk factors ; Risk management ; Seroepidemiologic Studies ; Serology ; Triglycerides ; Type 2 diabetes</subject><ispartof>International Journal of Obesity, 2020-01, Vol.44 (1), p.159-166</ispartof><rights>Springer Nature Limited 2019</rights><rights>COPYRIGHT 2020 Nature Publishing Group</rights><rights>2019© Springer Nature Limited 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-d0ca8c2b8a1aee08696d55f3483956a098c77b141bc0eb03e406b900e8c447603</citedby><cites>FETCH-LOGICAL-c470t-d0ca8c2b8a1aee08696d55f3483956a098c77b141bc0eb03e406b900e8c447603</cites><orcidid>0000-0003-3428-8332</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30659258$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapunar, Jorge</creatorcontrib><creatorcontrib>Fonseca, Luis</creatorcontrib><creatorcontrib>Molina, Víctor</creatorcontrib><creatorcontrib>Ortiz, Eugenia</creatorcontrib><creatorcontrib>Barra, Maria Ines</creatorcontrib><creatorcontrib>Reimer, Camila</creatorcontrib><creatorcontrib>Charles, Maria</creatorcontrib><creatorcontrib>Schneider, Constance</creatorcontrib><creatorcontrib>Ortiz, Manuel</creatorcontrib><creatorcontrib>Brito, Roberto</creatorcontrib><creatorcontrib>Manríquez, Víctor</creatorcontrib><creatorcontrib>Pavez, Monica</creatorcontrib><creatorcontrib>Cerda, Alvaro</creatorcontrib><title>Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population.
Subjects and methods
Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5–24.9 kg/m
2
) and 151 obese (BMI > 30 kg/m
2
) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay.
Results
Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58–4.51,
p
< 0.001). Interestingly, Ad-36 was related to lower concentrations of triglycerides and VLDL cholesterol in lean subjects (
p
= 0.049) and lower leptin in obese individuals (
p
= 0.014). Previous Ad-36 infection was also related to lower glycemia, insulinemia, and HOMA-IR (
p
< 0.05) in obese subjects who were not under antidiabetic drugs.
Conclusions
Our results provide evidence of the contribution of previous Ad-36 infection to an increased risk of obesity in adult Chilean population. Ad-36 seropositivity was also associated to lipid profile, glycemic control, and leptin levels in adult Chilean population.</description><subject>692/163/2743/393</subject><subject>692/499</subject><subject>82/1</subject><subject>82/80</subject><subject>Adenoviridae - immunology</subject><subject>Adenoviridae Infections - complications</subject><subject>Adenoviridae Infections - epidemiology</subject><subject>Adenoviridae Infections - immunology</subject><subject>Adenovirus</subject><subject>Adenoviruses</subject><subject>Adiponectin</subject><subject>Adipose tissue</subject><subject>Adult</subject><subject>Advertising executives</subject><subject>Anthropometry</subject><subject>Antibodies, Viral - blood</subject><subject>Antidiabetics</subject><subject>Blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Chile</subject><subject>Cholesterol</subject><subject>Dextrose</subject><subject>Diabetes mellitus</subject><subject>Diabetes therapy</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Hypoglycemic agents</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Laboratory tests</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Lipids</subject><subject>Lipoproteins (very low density)</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Population</subject><subject>Population studies</subject><subject>Public Health</subject><subject>Risk factors</subject><subject>Risk management</subject><subject>Seroepidemiologic Studies</subject><subject>Serology</subject><subject>Triglycerides</subject><subject>Type 2 diabetes</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kl-PEyEUxSdG43ZXP4AvhsTE7MPOehkGhnlsGv8lm_iiz4RhblsqhQpMk357mXTVXaPh4RL4nRvu4VTVKwq3FJh8l1rKhKiB9jWwhtbtk2pB207UvO27p9UCGHQ1cMEvqsuUdgDAOTTPqwsGgvcNl4vqsBzRh6ONUyJMkIQxHEKy2R5tPhGbSESnM44kBxIGTPNptOn7Ddm4k8G9NcQEn2NwN0T7kTg8ZOtLOaJLpOxWW-tQe5KmYYcmpxfVs7V2CV_e16vq24f3X1ef6rsvHz-vlne1aTvI9QhGS9MMUlONCFL0YuR8zVrJei409NJ03UBbOhjAARi2IIYeAKVpiwPArqrrc99DDD8mTFntbTLonPYYpqQa2vXFvE7O6Ju_0F2Yoi-vUw1rZEehEQ-ojXaorF-HHLWZm6qlgL6RjPdtoW7_QZU1zl4Fj-tix2PB2weCLWqXtym4Kdvg02OQnkETQ0oR1-oQ7V7Hk6Kg5jiocxxUiYOa46Bmzev7yaZhj-Nvxa__L0BzBlK58huMf0b_f9efW8K9LQ</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Sapunar, Jorge</creator><creator>Fonseca, Luis</creator><creator>Molina, Víctor</creator><creator>Ortiz, Eugenia</creator><creator>Barra, Maria Ines</creator><creator>Reimer, Camila</creator><creator>Charles, Maria</creator><creator>Schneider, Constance</creator><creator>Ortiz, Manuel</creator><creator>Brito, Roberto</creator><creator>Manríquez, Víctor</creator><creator>Pavez, Monica</creator><creator>Cerda, Alvaro</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3428-8332</orcidid></search><sort><creationdate>20200101</creationdate><title>Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects</title><author>Sapunar, Jorge ; Fonseca, Luis ; Molina, Víctor ; Ortiz, Eugenia ; Barra, Maria Ines ; Reimer, Camila ; Charles, Maria ; Schneider, Constance ; Ortiz, Manuel ; Brito, Roberto ; Manríquez, Víctor ; Pavez, Monica ; Cerda, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-d0ca8c2b8a1aee08696d55f3483956a098c77b141bc0eb03e406b900e8c447603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/163/2743/393</topic><topic>692/499</topic><topic>82/1</topic><topic>82/80</topic><topic>Adenoviridae - immunology</topic><topic>Adenoviridae Infections - complications</topic><topic>Adenoviridae Infections - epidemiology</topic><topic>Adenoviridae Infections - immunology</topic><topic>Adenovirus</topic><topic>Adenoviruses</topic><topic>Adiponectin</topic><topic>Adipose tissue</topic><topic>Adult</topic><topic>Advertising executives</topic><topic>Anthropometry</topic><topic>Antibodies, Viral - blood</topic><topic>Antidiabetics</topic><topic>Blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Case-Control Studies</topic><topic>Children</topic><topic>Chile</topic><topic>Cholesterol</topic><topic>Dextrose</topic><topic>Diabetes mellitus</topic><topic>Diabetes therapy</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Glucose</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Hypoglycemic agents</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Laboratory tests</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Lipids</topic><topic>Lipoproteins (very low density)</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Population</topic><topic>Population studies</topic><topic>Public Health</topic><topic>Risk factors</topic><topic>Risk management</topic><topic>Seroepidemiologic Studies</topic><topic>Serology</topic><topic>Triglycerides</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapunar, Jorge</creatorcontrib><creatorcontrib>Fonseca, Luis</creatorcontrib><creatorcontrib>Molina, Víctor</creatorcontrib><creatorcontrib>Ortiz, Eugenia</creatorcontrib><creatorcontrib>Barra, Maria Ines</creatorcontrib><creatorcontrib>Reimer, Camila</creatorcontrib><creatorcontrib>Charles, Maria</creatorcontrib><creatorcontrib>Schneider, Constance</creatorcontrib><creatorcontrib>Ortiz, Manuel</creatorcontrib><creatorcontrib>Brito, Roberto</creatorcontrib><creatorcontrib>Manríquez, Víctor</creatorcontrib><creatorcontrib>Pavez, Monica</creatorcontrib><creatorcontrib>Cerda, Alvaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapunar, Jorge</au><au>Fonseca, Luis</au><au>Molina, Víctor</au><au>Ortiz, Eugenia</au><au>Barra, Maria Ines</au><au>Reimer, Camila</au><au>Charles, Maria</au><au>Schneider, Constance</au><au>Ortiz, Manuel</au><au>Brito, Roberto</au><au>Manríquez, Víctor</au><au>Pavez, Monica</au><au>Cerda, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>44</volume><issue>1</issue><spage>159</spage><epage>166</epage><pages>159-166</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background
Adenovirus 36 (Ad-36) has been associated to adiposity in animal and in vitro studies. Ad-36 seropositivity has also been reported to contribute to obesity risk in children and adult populations. We investigated the relationship of Ad-36 serology with obesity and metabolic parameters in a Chilean population.
Subjects and methods
Clinical and anthropometric data were obtained and blood samples were drawn from 99 lean (BMI: 18.5–24.9 kg/m
2
) and 151 obese (BMI > 30 kg/m
2
) subjects. Laboratory tests included lipid profile as well as glucose, insulin, leptin, and adiponectin levels. Ad-36 seropositivity was evaluated in serum samples by enzyme-linked immunosorbent assay.
Results
Seroprevalence of Ad-36 was higher in the obese group (58%) than in lean controls (34%) demonstrating that individuals previously infected with Ad-36 have higher risk of obesity in the study population (OR: 2.67, 95%CI: 1.58–4.51,
p
< 0.001). Interestingly, Ad-36 was related to lower concentrations of triglycerides and VLDL cholesterol in lean subjects (
p
= 0.049) and lower leptin in obese individuals (
p
= 0.014). Previous Ad-36 infection was also related to lower glycemia, insulinemia, and HOMA-IR (
p
< 0.05) in obese subjects who were not under antidiabetic drugs.
Conclusions
Our results provide evidence of the contribution of previous Ad-36 infection to an increased risk of obesity in adult Chilean population. Ad-36 seropositivity was also associated to lipid profile, glycemic control, and leptin levels in adult Chilean population.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30659258</pmid><doi>10.1038/s41366-019-0321-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3428-8332</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | International Journal of Obesity, 2020-01, Vol.44 (1), p.159-166 |
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| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 692/163/2743/393 692/499 82/1 82/80 Adenoviridae - immunology Adenoviridae Infections - complications Adenoviridae Infections - epidemiology Adenoviridae Infections - immunology Adenovirus Adenoviruses Adiponectin Adipose tissue Adult Advertising executives Anthropometry Antibodies, Viral - blood Antidiabetics Blood glucose Blood Glucose - analysis Case-Control Studies Children Chile Cholesterol Dextrose Diabetes mellitus Diabetes therapy Enzyme-linked immunosorbent assay Enzymes Epidemiology Female Glucose Health aspects Health Promotion and Disease Prevention Health risk assessment Humans Hypoglycemic agents Insulin Internal Medicine Laboratory tests Leptin Leptin - blood Lipids Lipoproteins (very low density) Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Obesity Obesity - complications Obesity - epidemiology Population Population studies Public Health Risk factors Risk management Seroepidemiologic Studies Serology Triglycerides Type 2 diabetes |
| title | Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects |
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