The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis
Background & Aims Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests. Methods Two hundred and fourteen patients with cirrhosis were enrolled. On the d...
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| Veröffentlicht in: | Liver international 2019-05, Vol.39 (5), p.861-870 |
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| creator | Zarantonello, Lisa Turco, Matteo Formentin, Chiara Izquierdo‐Altarejos, Paula Vuerich, Anna Barcenas Jimenez, Maria J. Montoliu, Carmina Felipo, Vicente Angeli, Paolo Amodio, Piero Montagnese, Sara |
| description | Background & Aims
Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests.
Methods
Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail‐making test A (TMT‐A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT).
Results
Both patients with and without OHE history improved in TMT‐A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT‐A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for.
Conclusions
HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well‐characterized group of patients with cirrhosis. |
| doi_str_mv | 10.1111/liv.14046 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179362374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179362374</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3536-1d83911e5bef9cf721871f4b905eb01fc5cf3267d779e9572d645185a1b677e23</originalsourceid><addsrcrecordid>eNp1kU1LHTEUhkNpUWtd9A-UQDct9Go-JslkKWKrcKEb223IZBInkptMk4wy_76x17oQPJtzFs95OJwXgI8YneJWZ8Hfn-IOdfwNOMKd6DeUUPz2eSb0ELwv5Q4hLCXDB-CQIs56hPgRuL-ZLPTRhcVGY2Fy8OoSTr7UlNdvj3Opui4F6jjCaJec5rKaKYV0640OsNpSYV3nthlhsDpHH2-hHnzwdW1eOOvqbawFPvg6QeNznlLx5QN453Qo9uSpH4Nf3y9vLq42258_ri_OtxtDGeUbPPZUYmzZYJ00ThDcC-y6QSJmB4SdYcZRwsUohLSSCTLyjuGeaTxwISyhx-DL3jvn9Gdpx6qdL8aGoKNNS1EEC0k5oaJr6OcX6F1acmzXKUJwI3oieaO-7imTUynZOjVnv9N5VRipxzBUC0P9C6Oxn56My7Cz4zP5__sNONsDDz7Y9XWT2l7_3iv_AqkFk2c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2213748296</pqid></control><display><type>article</type><title>The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zarantonello, Lisa ; Turco, Matteo ; Formentin, Chiara ; Izquierdo‐Altarejos, Paula ; Vuerich, Anna ; Barcenas Jimenez, Maria J. ; Montoliu, Carmina ; Felipo, Vicente ; Angeli, Paolo ; Amodio, Piero ; Montagnese, Sara</creator><creatorcontrib>Zarantonello, Lisa ; Turco, Matteo ; Formentin, Chiara ; Izquierdo‐Altarejos, Paula ; Vuerich, Anna ; Barcenas Jimenez, Maria J. ; Montoliu, Carmina ; Felipo, Vicente ; Angeli, Paolo ; Amodio, Piero ; Montagnese, Sara</creatorcontrib><description>Background & Aims
Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests.
Methods
Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail‐making test A (TMT‐A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT).
Results
Both patients with and without OHE history improved in TMT‐A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT‐A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for.
Conclusions
HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well‐characterized group of patients with cirrhosis.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.14046</identifier><identifier>PMID: 30658006</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Cirrhosis ; Hepatic encephalopathy ; Learning ; learning ability ; Liver ; Liver cirrhosis ; Liver diseases ; neuropsychological test ; Reaction time ; Short term memory ; Test procedures</subject><ispartof>Liver international, 2019-05, Vol.39 (5), p.861-870</ispartof><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>2019 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3536-1d83911e5bef9cf721871f4b905eb01fc5cf3267d779e9572d645185a1b677e23</citedby><cites>FETCH-LOGICAL-c3536-1d83911e5bef9cf721871f4b905eb01fc5cf3267d779e9572d645185a1b677e23</cites><orcidid>0000-0002-2395-7599 ; 0000-0003-2800-9923</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fliv.14046$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fliv.14046$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30658006$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zarantonello, Lisa</creatorcontrib><creatorcontrib>Turco, Matteo</creatorcontrib><creatorcontrib>Formentin, Chiara</creatorcontrib><creatorcontrib>Izquierdo‐Altarejos, Paula</creatorcontrib><creatorcontrib>Vuerich, Anna</creatorcontrib><creatorcontrib>Barcenas Jimenez, Maria J.</creatorcontrib><creatorcontrib>Montoliu, Carmina</creatorcontrib><creatorcontrib>Felipo, Vicente</creatorcontrib><creatorcontrib>Angeli, Paolo</creatorcontrib><creatorcontrib>Amodio, Piero</creatorcontrib><creatorcontrib>Montagnese, Sara</creatorcontrib><title>The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background & Aims
Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests.
Methods
Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail‐making test A (TMT‐A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT).
Results
Both patients with and without OHE history improved in TMT‐A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT‐A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for.
Conclusions
HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well‐characterized group of patients with cirrhosis.</description><subject>Cirrhosis</subject><subject>Hepatic encephalopathy</subject><subject>Learning</subject><subject>learning ability</subject><subject>Liver</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>neuropsychological test</subject><subject>Reaction time</subject><subject>Short term memory</subject><subject>Test procedures</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LHTEUhkNpUWtd9A-UQDct9Go-JslkKWKrcKEb223IZBInkptMk4wy_76x17oQPJtzFs95OJwXgI8YneJWZ8Hfn-IOdfwNOMKd6DeUUPz2eSb0ELwv5Q4hLCXDB-CQIs56hPgRuL-ZLPTRhcVGY2Fy8OoSTr7UlNdvj3Opui4F6jjCaJec5rKaKYV0640OsNpSYV3nthlhsDpHH2-hHnzwdW1eOOvqbawFPvg6QeNznlLx5QN453Qo9uSpH4Nf3y9vLq42258_ri_OtxtDGeUbPPZUYmzZYJ00ThDcC-y6QSJmB4SdYcZRwsUohLSSCTLyjuGeaTxwISyhx-DL3jvn9Gdpx6qdL8aGoKNNS1EEC0k5oaJr6OcX6F1acmzXKUJwI3oieaO-7imTUynZOjVnv9N5VRipxzBUC0P9C6Oxn56My7Cz4zP5__sNONsDDz7Y9XWT2l7_3iv_AqkFk2c</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Zarantonello, Lisa</creator><creator>Turco, Matteo</creator><creator>Formentin, Chiara</creator><creator>Izquierdo‐Altarejos, Paula</creator><creator>Vuerich, Anna</creator><creator>Barcenas Jimenez, Maria J.</creator><creator>Montoliu, Carmina</creator><creator>Felipo, Vicente</creator><creator>Angeli, Paolo</creator><creator>Amodio, Piero</creator><creator>Montagnese, Sara</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2395-7599</orcidid><orcidid>https://orcid.org/0000-0003-2800-9923</orcidid></search><sort><creationdate>201905</creationdate><title>The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis</title><author>Zarantonello, Lisa ; Turco, Matteo ; Formentin, Chiara ; Izquierdo‐Altarejos, Paula ; Vuerich, Anna ; Barcenas Jimenez, Maria J. ; Montoliu, Carmina ; Felipo, Vicente ; Angeli, Paolo ; Amodio, Piero ; Montagnese, Sara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3536-1d83911e5bef9cf721871f4b905eb01fc5cf3267d779e9572d645185a1b677e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cirrhosis</topic><topic>Hepatic encephalopathy</topic><topic>Learning</topic><topic>learning ability</topic><topic>Liver</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>neuropsychological test</topic><topic>Reaction time</topic><topic>Short term memory</topic><topic>Test procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zarantonello, Lisa</creatorcontrib><creatorcontrib>Turco, Matteo</creatorcontrib><creatorcontrib>Formentin, Chiara</creatorcontrib><creatorcontrib>Izquierdo‐Altarejos, Paula</creatorcontrib><creatorcontrib>Vuerich, Anna</creatorcontrib><creatorcontrib>Barcenas Jimenez, Maria J.</creatorcontrib><creatorcontrib>Montoliu, Carmina</creatorcontrib><creatorcontrib>Felipo, Vicente</creatorcontrib><creatorcontrib>Angeli, Paolo</creatorcontrib><creatorcontrib>Amodio, Piero</creatorcontrib><creatorcontrib>Montagnese, Sara</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zarantonello, Lisa</au><au>Turco, Matteo</au><au>Formentin, Chiara</au><au>Izquierdo‐Altarejos, Paula</au><au>Vuerich, Anna</au><au>Barcenas Jimenez, Maria J.</au><au>Montoliu, Carmina</au><au>Felipo, Vicente</au><au>Angeli, Paolo</au><au>Amodio, Piero</au><au>Montagnese, Sara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2019-05</date><risdate>2019</risdate><volume>39</volume><issue>5</issue><spage>861</spage><epage>870</epage><pages>861-870</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background & Aims
Learning ability may be impaired in patients with a history of overt hepatic encephalopathy (OHE). The aim of this study was to compare performance on the first/second attempt at a series of tests.
Methods
Two hundred and fourteen patients with cirrhosis were enrolled. On the day of study, 41% were classed as unimpaired, 38% as having minimal HE and 21% as having mild OHE; 58% had a history of OHE. Performance was compared between two versions of the trail‐making test A (TMT‐A), and between the first/second half of a simple/choice reaction time (sRT and cRT), and a working memory test (ScanRT).
Results
Both patients with and without OHE history improved in TMT‐A, sRT and ScanRT. Only patients with no OHE history improved in cRT. All patients, regardless of their HE status on the day of study, improved in TMT‐A and sRT. Only patients with mild OHE on the day of study improved in cRT. Only unimpaired patients improved in ScanRT. When OHE history and HE status on the day of study were tested together, only HE status had an effect. The same held true when age, the Model for End Stage Liver Disease (MELD) and educational attainment were adjusted for.
Conclusions
HE status on the day of study and the type of neuropsychological test had an effect on learning ability in a well‐characterized group of patients with cirrhosis.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30658006</pmid><doi>10.1111/liv.14046</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2395-7599</orcidid><orcidid>https://orcid.org/0000-0003-2800-9923</orcidid></addata></record> |
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| ispartof | Liver international, 2019-05, Vol.39 (5), p.861-870 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Cirrhosis Hepatic encephalopathy Learning learning ability Liver Liver cirrhosis Liver diseases neuropsychological test Reaction time Short term memory Test procedures |
| title | The influence of HE history, HE status and neuropsychological test type on learning ability in patients with cirrhosis |
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