A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single-nucleotide polymorphisms (SNPs) in the apoptotic cell–engulfment genes ELMO1, DOCK2 , and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganizatio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2019-02, Vol.20 (2), p.141-151
Hauptverfasser:	Arandjelovic, Sanja, Perry, Justin S. A., Lucas, Christopher D., Penberthy, Kristen K., Kim, Tae-Hyoun, Zhou, Ming, Rosen, Dorian A, Chuang, Tzu-Ying, Bettina, Alexandra M., Shankman, Laura S., Cohen, Amanda H., Gaultier, Alban, Conrads, Thomas P., Kim, Minsoo, Elliott, Michael R., Ravichandran, Kodi S.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/337 631/80 692/699/249 Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Animal models Animals Apoptosis Apoptosis - immunology Arthritis Arthritis, Experimental - diagnosis Arthritis, Experimental - genetics Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Biomedical and Life Sciences Biomedicine Cell activation Cell culture Chemokines Chemotaxis - genetics Chemotaxis - immunology Collagen - immunology Complement C5a - immunology Complement C5a - metabolism Cytoplasm - immunology Cytoplasm - metabolism Cytoskeleton Disease Models, Animal Female Gene Expression Profiling Genes Genetic aspects Genetic polymorphisms Healthy Volunteers Human migration Human populations Humans Immunology Infectious Diseases Inflammation Intravital Microscopy Joint diseases Joints - cytology Joints - immunology Leukocyte migration Leukocytes (neutrophilic) Leukotriene B4 - immunology Leukotriene B4 - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Neutrophils Neutrophils - immunology Neutrophils - metabolism Peripheral blood Polymorphism, Single Nucleotide Promoters (Genetics) Proteomics Rac1 protein Receptor mechanisms Rheumatoid arthritis Rheumatoid factor Severity of Illness Index Signal Transduction - immunology Single nucleotide polymorphisms Single-nucleotide polymorphism Time-Lapse Imaging
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!