Key Viral Adaptations Preceding the AIDS Pandemic
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insigh...
Gespeichert in:
| Veröffentlicht in: | Cell host & microbe 2019-01, Vol.25 (1), p.27-38 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 38 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Cell host & microbe |
| container_volume | 25 |
| creator | Sauter, Daniel Kirchhoff, Frank |
| description | HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insights into innate defense mechanisms, viral dependencies on cellular factors, and prerequisites for the emergence of the AIDS pandemic. In addition, understanding the factors and adaptations required for the spread of HIV in the human population helps to better assess the risk of future lentiviral zoonoses and provides clues to how improved control of viral replication can be achieved. Here, we summarize our current knowledge on viral features and adaptations preceding the AIDS pandemic. We aim at providing a viral point of view, focusing on known key hurdles of each cross-species transmission and the mechanisms that HIV and its simian precursors evolved to overcome them.
Simian immunodeficiency viruses crossed the barrier from great apes and monkeys to humans on at least 13 occasions, but only a single transmission is responsible for the AIDS pandemic. Sauter and Kirchhoff summarize the cross-species transmission events and adaptations allowing pandemic HIV-1 strains to spread efficiently in the human population. |
| doi_str_mv | 10.1016/j.chom.2018.12.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179358223</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1931312818306292</els_id><sourcerecordid>2179358223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-ce52ae298aa116336ae0a945b9d123e5456342aafae84b08f0f0951199e5d1e13</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EolD4ARYoSzYJHjt2Y4lNVV4VlajEY2u5zoS6yqPYKVL_noQWlqzmLs690hxCLoAmQEFerxK7bKqEUcgSYAml7ICcgOJpLKlUhz8ZYg4sG5DTEFaUCkFHcEwGnEqmFIgTAk-4jd6dN2U0zs26Na1r6hDNPVrMXf0RtUuMxtPbl2hu6hwrZ8_IUWHKgOf7OyRv93evk8d49vwwnYxnsU2lbGOLghlkKjMGQHIuDVKjUrFQOTCOIhWSp8yYwmCWLmhW0IIqAaAUihwQ-JBc7XbXvvncYGh15YLFsjQ1NpugGYwUFxljvEPZDrW-CcFjodfeVcZvNVDdq9Ir3avSvSoNTHequtLlfn-zqDD_q_y66YCbHYDdl18OvQ7WYd176ey0Om_cf_vf3OV3vA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2179358223</pqid></control><display><type>article</type><title>Key Viral Adaptations Preceding the AIDS Pandemic</title><source>MEDLINE</source><source>Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Sauter, Daniel ; Kirchhoff, Frank</creator><creatorcontrib>Sauter, Daniel ; Kirchhoff, Frank</creatorcontrib><description>HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insights into innate defense mechanisms, viral dependencies on cellular factors, and prerequisites for the emergence of the AIDS pandemic. In addition, understanding the factors and adaptations required for the spread of HIV in the human population helps to better assess the risk of future lentiviral zoonoses and provides clues to how improved control of viral replication can be achieved. Here, we summarize our current knowledge on viral features and adaptations preceding the AIDS pandemic. We aim at providing a viral point of view, focusing on known key hurdles of each cross-species transmission and the mechanisms that HIV and its simian precursors evolved to overcome them.
Simian immunodeficiency viruses crossed the barrier from great apes and monkeys to humans on at least 13 occasions, but only a single transmission is responsible for the AIDS pandemic. Sauter and Kirchhoff summarize the cross-species transmission events and adaptations allowing pandemic HIV-1 strains to spread efficiently in the human population.</description><identifier>ISSN: 1931-3128</identifier><identifier>EISSN: 1934-6069</identifier><identifier>DOI: 10.1016/j.chom.2018.12.002</identifier><identifier>PMID: 30629915</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - transmission ; Acquired Immunodeficiency Syndrome - veterinary ; Acquired Immunodeficiency Syndrome - virology ; adaptation ; Adaptation, Physiological - genetics ; Adaptation, Physiological - immunology ; AIDS ; Animals ; Animals, Wild - virology ; arms race ; evolution ; Gorilla gorilla - virology ; Haplorhini - virology ; HIV ; HIV-1 - genetics ; HIV-1 - immunology ; HIV-1 - pathogenicity ; HIV-2 - genetics ; HIV-2 - immunology ; HIV-2 - pathogenicity ; Host Specificity ; Humans ; Immunity, Innate ; Pan troglodytes - virology ; Pandemics - veterinary ; Primate Diseases - virology ; primate lentiviruses ; Recombination, Genetic ; restriction factors ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - transmission ; Simian Acquired Immunodeficiency Syndrome - virology ; Simian Immunodeficiency Virus - genetics ; Simian Immunodeficiency Virus - immunology ; Simian Immunodeficiency Virus - pathogenicity ; Species Specificity ; viral zoonoses ; Virus Replication ; Zoonoses - immunology ; Zoonoses - transmission ; Zoonoses - virology</subject><ispartof>Cell host & microbe, 2019-01, Vol.25 (1), p.27-38</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-ce52ae298aa116336ae0a945b9d123e5456342aafae84b08f0f0951199e5d1e13</citedby><cites>FETCH-LOGICAL-c466t-ce52ae298aa116336ae0a945b9d123e5456342aafae84b08f0f0951199e5d1e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chom.2018.12.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30629915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauter, Daniel</creatorcontrib><creatorcontrib>Kirchhoff, Frank</creatorcontrib><title>Key Viral Adaptations Preceding the AIDS Pandemic</title><title>Cell host & microbe</title><addtitle>Cell Host Microbe</addtitle><description>HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insights into innate defense mechanisms, viral dependencies on cellular factors, and prerequisites for the emergence of the AIDS pandemic. In addition, understanding the factors and adaptations required for the spread of HIV in the human population helps to better assess the risk of future lentiviral zoonoses and provides clues to how improved control of viral replication can be achieved. Here, we summarize our current knowledge on viral features and adaptations preceding the AIDS pandemic. We aim at providing a viral point of view, focusing on known key hurdles of each cross-species transmission and the mechanisms that HIV and its simian precursors evolved to overcome them.
Simian immunodeficiency viruses crossed the barrier from great apes and monkeys to humans on at least 13 occasions, but only a single transmission is responsible for the AIDS pandemic. Sauter and Kirchhoff summarize the cross-species transmission events and adaptations allowing pandemic HIV-1 strains to spread efficiently in the human population.</description><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - transmission</subject><subject>Acquired Immunodeficiency Syndrome - veterinary</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>adaptation</subject><subject>Adaptation, Physiological - genetics</subject><subject>Adaptation, Physiological - immunology</subject><subject>AIDS</subject><subject>Animals</subject><subject>Animals, Wild - virology</subject><subject>arms race</subject><subject>evolution</subject><subject>Gorilla gorilla - virology</subject><subject>Haplorhini - virology</subject><subject>HIV</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - pathogenicity</subject><subject>HIV-2 - genetics</subject><subject>HIV-2 - immunology</subject><subject>HIV-2 - pathogenicity</subject><subject>Host Specificity</subject><subject>Humans</subject><subject>Immunity, Innate</subject><subject>Pan troglodytes - virology</subject><subject>Pandemics - veterinary</subject><subject>Primate Diseases - virology</subject><subject>primate lentiviruses</subject><subject>Recombination, Genetic</subject><subject>restriction factors</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - transmission</subject><subject>Simian Acquired Immunodeficiency Syndrome - virology</subject><subject>Simian Immunodeficiency Virus - genetics</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>Simian Immunodeficiency Virus - pathogenicity</subject><subject>Species Specificity</subject><subject>viral zoonoses</subject><subject>Virus Replication</subject><subject>Zoonoses - immunology</subject><subject>Zoonoses - transmission</subject><subject>Zoonoses - virology</subject><issn>1931-3128</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EolD4ARYoSzYJHjt2Y4lNVV4VlajEY2u5zoS6yqPYKVL_noQWlqzmLs690hxCLoAmQEFerxK7bKqEUcgSYAml7ICcgOJpLKlUhz8ZYg4sG5DTEFaUCkFHcEwGnEqmFIgTAk-4jd6dN2U0zs26Na1r6hDNPVrMXf0RtUuMxtPbl2hu6hwrZ8_IUWHKgOf7OyRv93evk8d49vwwnYxnsU2lbGOLghlkKjMGQHIuDVKjUrFQOTCOIhWSp8yYwmCWLmhW0IIqAaAUihwQ-JBc7XbXvvncYGh15YLFsjQ1NpugGYwUFxljvEPZDrW-CcFjodfeVcZvNVDdq9Ir3avSvSoNTHequtLlfn-zqDD_q_y66YCbHYDdl18OvQ7WYd176ey0Om_cf_vf3OV3vA</recordid><startdate>20190109</startdate><enddate>20190109</enddate><creator>Sauter, Daniel</creator><creator>Kirchhoff, Frank</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190109</creationdate><title>Key Viral Adaptations Preceding the AIDS Pandemic</title><author>Sauter, Daniel ; Kirchhoff, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-ce52ae298aa116336ae0a945b9d123e5456342aafae84b08f0f0951199e5d1e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acquired Immunodeficiency Syndrome - immunology</topic><topic>Acquired Immunodeficiency Syndrome - transmission</topic><topic>Acquired Immunodeficiency Syndrome - veterinary</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>adaptation</topic><topic>Adaptation, Physiological - genetics</topic><topic>Adaptation, Physiological - immunology</topic><topic>AIDS</topic><topic>Animals</topic><topic>Animals, Wild - virology</topic><topic>arms race</topic><topic>evolution</topic><topic>Gorilla gorilla - virology</topic><topic>Haplorhini - virology</topic><topic>HIV</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 - pathogenicity</topic><topic>HIV-2 - genetics</topic><topic>HIV-2 - immunology</topic><topic>HIV-2 - pathogenicity</topic><topic>Host Specificity</topic><topic>Humans</topic><topic>Immunity, Innate</topic><topic>Pan troglodytes - virology</topic><topic>Pandemics - veterinary</topic><topic>Primate Diseases - virology</topic><topic>primate lentiviruses</topic><topic>Recombination, Genetic</topic><topic>restriction factors</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - transmission</topic><topic>Simian Acquired Immunodeficiency Syndrome - virology</topic><topic>Simian Immunodeficiency Virus - genetics</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>Simian Immunodeficiency Virus - pathogenicity</topic><topic>Species Specificity</topic><topic>viral zoonoses</topic><topic>Virus Replication</topic><topic>Zoonoses - immunology</topic><topic>Zoonoses - transmission</topic><topic>Zoonoses - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauter, Daniel</creatorcontrib><creatorcontrib>Kirchhoff, Frank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauter, Daniel</au><au>Kirchhoff, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Key Viral Adaptations Preceding the AIDS Pandemic</atitle><jtitle>Cell host & microbe</jtitle><addtitle>Cell Host Microbe</addtitle><date>2019-01-09</date><risdate>2019</risdate><volume>25</volume><issue>1</issue><spage>27</spage><epage>38</epage><pages>27-38</pages><issn>1931-3128</issn><eissn>1934-6069</eissn><abstract>HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-species transmissions and recombination events as well as changes in the repertoire and function of its accessory genes. Understanding these events and the adaptations to new host species provides key insights into innate defense mechanisms, viral dependencies on cellular factors, and prerequisites for the emergence of the AIDS pandemic. In addition, understanding the factors and adaptations required for the spread of HIV in the human population helps to better assess the risk of future lentiviral zoonoses and provides clues to how improved control of viral replication can be achieved. Here, we summarize our current knowledge on viral features and adaptations preceding the AIDS pandemic. We aim at providing a viral point of view, focusing on known key hurdles of each cross-species transmission and the mechanisms that HIV and its simian precursors evolved to overcome them.
Simian immunodeficiency viruses crossed the barrier from great apes and monkeys to humans on at least 13 occasions, but only a single transmission is responsible for the AIDS pandemic. Sauter and Kirchhoff summarize the cross-species transmission events and adaptations allowing pandemic HIV-1 strains to spread efficiently in the human population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30629915</pmid><doi>10.1016/j.chom.2018.12.002</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-3128 |
| ispartof | Cell host & microbe, 2019-01, Vol.25 (1), p.27-38 |
| issn | 1931-3128 1934-6069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179358223 |
| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - transmission Acquired Immunodeficiency Syndrome - veterinary Acquired Immunodeficiency Syndrome - virology adaptation Adaptation, Physiological - genetics Adaptation, Physiological - immunology AIDS Animals Animals, Wild - virology arms race evolution Gorilla gorilla - virology Haplorhini - virology HIV HIV-1 - genetics HIV-1 - immunology HIV-1 - pathogenicity HIV-2 - genetics HIV-2 - immunology HIV-2 - pathogenicity Host Specificity Humans Immunity, Innate Pan troglodytes - virology Pandemics - veterinary Primate Diseases - virology primate lentiviruses Recombination, Genetic restriction factors Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - transmission Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - pathogenicity Species Specificity viral zoonoses Virus Replication Zoonoses - immunology Zoonoses - transmission Zoonoses - virology |
| title | Key Viral Adaptations Preceding the AIDS Pandemic |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T22%3A40%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Key%20Viral%20Adaptations%20Preceding%20the%20AIDS%20Pandemic&rft.jtitle=Cell%20host%20&%20microbe&rft.au=Sauter,%20Daniel&rft.date=2019-01-09&rft.volume=25&rft.issue=1&rft.spage=27&rft.epage=38&rft.pages=27-38&rft.issn=1931-3128&rft.eissn=1934-6069&rft_id=info:doi/10.1016/j.chom.2018.12.002&rft_dat=%3Cproquest_cross%3E2179358223%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2179358223&rft_id=info:pmid/30629915&rft_els_id=S1931312818306292&rfr_iscdi=true |