Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi
Mediator complex has recently emerged as an important regulator of gene expression in pathogenic fungi. Mediator is a multi-subunit complex of polypeptides involved in transcriptional activation in eukaryotes, with roles including preinitiation complex (PIC) assembly and chromatin remodeling. Within...
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| Veröffentlicht in: | Current genetics 2019-06, Vol.65 (3), p.621-630 |
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| creator | Moran, Gary P. Anderson, Matthew Z. Myers, Lawrence C. Sullivan, Derek J. |
| description | Mediator complex has recently emerged as an important regulator of gene expression in pathogenic fungi. Mediator is a multi-subunit complex of polypeptides involved in transcriptional activation in eukaryotes, with roles including preinitiation complex (PIC) assembly and chromatin remodeling. Within the last decade, Mediator has been shown to play an integral role in regulating virulence gene expression and drug resistance in human fungal pathogens. In some fungi, specific Mediator subunits have been shown to be required for virulence. In
Candida
species, duplication and expansion of Mediator subunit encoding genes has occurred on at least three occasions (
CgMED15
in
C. glabrata
and
MED2/TLO
in
C. albicans
and
C. dubliniensis
) suggesting important roles for Mediator in the evolution of these pathogens. This review summarises recent developments in our understanding of Mediator in fungal pathogens and the potential for the development of therapeutic drugs to target Mediator functions. |
| doi_str_mv | 10.1007/s00294-019-00932-8 |
| format | Article |
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Candida
species, duplication and expansion of Mediator subunit encoding genes has occurred on at least three occasions (
CgMED15
in
C. glabrata
and
MED2/TLO
in
C. albicans
and
C. dubliniensis
) suggesting important roles for Mediator in the evolution of these pathogens. This review summarises recent developments in our understanding of Mediator in fungal pathogens and the potential for the development of therapeutic drugs to target Mediator functions.</description><identifier>ISSN: 0172-8083</identifier><identifier>EISSN: 1432-0983</identifier><identifier>DOI: 10.1007/s00294-019-00932-8</identifier><identifier>PMID: 30637479</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antifungal agents ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Chromatin remodeling ; Drug development ; Drug resistance ; Eukaryotes ; Fungi ; Fungicides ; Gene expression ; Life Sciences ; Microbial Genetics and Genomics ; Microbiology ; Pathogens ; Plant Sciences ; Polypeptides ; Proteomics ; Review ; Transcription activation ; Virulence</subject><ispartof>Current genetics, 2019-06, Vol.65 (3), p.621-630</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Current Genetics is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a61a0be7a54ea3993b3c6cefa7a6a50a61e102ed867c960c5e57fcca0844f49a3</citedby><cites>FETCH-LOGICAL-c375t-a61a0be7a54ea3993b3c6cefa7a6a50a61e102ed867c960c5e57fcca0844f49a3</cites><orcidid>0000-0003-0469-1788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00294-019-00932-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00294-019-00932-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30637479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moran, Gary P.</creatorcontrib><creatorcontrib>Anderson, Matthew Z.</creatorcontrib><creatorcontrib>Myers, Lawrence C.</creatorcontrib><creatorcontrib>Sullivan, Derek J.</creatorcontrib><title>Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi</title><title>Current genetics</title><addtitle>Curr Genet</addtitle><addtitle>Curr Genet</addtitle><description>Mediator complex has recently emerged as an important regulator of gene expression in pathogenic fungi. Mediator is a multi-subunit complex of polypeptides involved in transcriptional activation in eukaryotes, with roles including preinitiation complex (PIC) assembly and chromatin remodeling. Within the last decade, Mediator has been shown to play an integral role in regulating virulence gene expression and drug resistance in human fungal pathogens. In some fungi, specific Mediator subunits have been shown to be required for virulence. In
Candida
species, duplication and expansion of Mediator subunit encoding genes has occurred on at least three occasions (
CgMED15
in
C. glabrata
and
MED2/TLO
in
C. albicans
and
C. dubliniensis
) suggesting important roles for Mediator in the evolution of these pathogens. This review summarises recent developments in our understanding of Mediator in fungal pathogens and the potential for the development of therapeutic drugs to target Mediator functions.</description><subject>Antifungal agents</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Chromatin remodeling</subject><subject>Drug development</subject><subject>Drug resistance</subject><subject>Eukaryotes</subject><subject>Fungi</subject><subject>Fungicides</subject><subject>Gene expression</subject><subject>Life Sciences</subject><subject>Microbial Genetics and Genomics</subject><subject>Microbiology</subject><subject>Pathogens</subject><subject>Plant Sciences</subject><subject>Polypeptides</subject><subject>Proteomics</subject><subject>Review</subject><subject>Transcription activation</subject><subject>Virulence</subject><issn>0172-8083</issn><issn>1432-0983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtKxDAUhoMoOl5ewIUU3LipnjRtLksRb6AooutwJj0dI512TFrBtzfjeAEXLkJC_u_8CR9j-xyOOYA6iQCFKXPgJgcwosj1GpvwMh3AaLHOJsBVugQttth2jC8AvNBGbbItAVKoUpkJu3_oW8r6Jrul2uPQh8x32ZsPY0udowy7Oq3BN2M3wzarwzjLAkUfB1zGiV3g8NzPqPMuW0J-l2002Eba-9p32NPF-ePZVX5zd3l9dnqTO6GqIUfJEaaksCoJhTFiKpx01KBCiRWkmDgUVGupnJHgKqpU4xyCLsumNCh22NGqdxH615HiYOc-Ompb7Kgfoy24MqJSohAJPfyDvvRj6NLvEiWl1rIqeaKKFeVCH2Ogxi6Cn2N4txzs0rdd-bbJt_30bXUaOviqHqdzqn9GvgUnQKyAmKJuRuH37X9qPwC1sorx</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Moran, Gary P.</creator><creator>Anderson, Matthew Z.</creator><creator>Myers, Lawrence C.</creator><creator>Sullivan, Derek J.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0469-1788</orcidid></search><sort><creationdate>20190601</creationdate><title>Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi</title><author>Moran, Gary P. ; Anderson, Matthew Z. ; Myers, Lawrence C. ; Sullivan, Derek J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a61a0be7a54ea3993b3c6cefa7a6a50a61e102ed867c960c5e57fcca0844f49a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antifungal agents</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Chromatin remodeling</topic><topic>Drug development</topic><topic>Drug resistance</topic><topic>Eukaryotes</topic><topic>Fungi</topic><topic>Fungicides</topic><topic>Gene expression</topic><topic>Life Sciences</topic><topic>Microbial Genetics and Genomics</topic><topic>Microbiology</topic><topic>Pathogens</topic><topic>Plant Sciences</topic><topic>Polypeptides</topic><topic>Proteomics</topic><topic>Review</topic><topic>Transcription activation</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moran, Gary P.</creatorcontrib><creatorcontrib>Anderson, Matthew Z.</creatorcontrib><creatorcontrib>Myers, Lawrence C.</creatorcontrib><creatorcontrib>Sullivan, Derek J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Current genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moran, Gary P.</au><au>Anderson, Matthew Z.</au><au>Myers, Lawrence C.</au><au>Sullivan, Derek J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi</atitle><jtitle>Current genetics</jtitle><stitle>Curr Genet</stitle><addtitle>Curr Genet</addtitle><date>2019-06-01</date><risdate>2019</risdate><volume>65</volume><issue>3</issue><spage>621</spage><epage>630</epage><pages>621-630</pages><issn>0172-8083</issn><eissn>1432-0983</eissn><abstract>Mediator complex has recently emerged as an important regulator of gene expression in pathogenic fungi. Mediator is a multi-subunit complex of polypeptides involved in transcriptional activation in eukaryotes, with roles including preinitiation complex (PIC) assembly and chromatin remodeling. Within the last decade, Mediator has been shown to play an integral role in regulating virulence gene expression and drug resistance in human fungal pathogens. In some fungi, specific Mediator subunits have been shown to be required for virulence. In
Candida
species, duplication and expansion of Mediator subunit encoding genes has occurred on at least three occasions (
CgMED15
in
C. glabrata
and
MED2/TLO
in
C. albicans
and
C. dubliniensis
) suggesting important roles for Mediator in the evolution of these pathogens. This review summarises recent developments in our understanding of Mediator in fungal pathogens and the potential for the development of therapeutic drugs to target Mediator functions.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30637479</pmid><doi>10.1007/s00294-019-00932-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0469-1788</orcidid></addata></record> |
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| subjects | Antifungal agents Biochemistry Biomedical and Life Sciences Cell Biology Chromatin remodeling Drug development Drug resistance Eukaryotes Fungi Fungicides Gene expression Life Sciences Microbial Genetics and Genomics Microbiology Pathogens Plant Sciences Polypeptides Proteomics Review Transcription activation Virulence |
| title | Role of Mediator in virulence and antifungal drug resistance in pathogenic fungi |
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