Metal-based antitumor compounds: beyond cisplatin

Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely low survival rates. The establishment of chemoresistance, responsible for the reduction in treatm...

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Veröffentlicht in:	Future medicinal chemistry 2019-01, Vol.11 (2), p.119-135
Hauptverfasser:	Simpson, Peter V, Desai, Nima Maheshkumar, Casari, Ilaria, Massi, Massimiliano, Falasca, Marco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic drugs Antitumor agents Apoptosis Brain tumors Cancer Cancer therapies Carboplatin - chemistry Carboplatin - pharmacology Carboplatin - therapeutic use Cell cycle Chemoresistance Chemotherapy Cisplatin Cisplatin - chemistry Cisplatin - pharmacology Cisplatin - therapeutic use Copper - chemistry Copper - pharmacology Copper - therapeutic use Cytotoxicity Disease Drug Discovery Drugs Gold - chemistry Gold - pharmacology Gold - therapeutic use Hodgkin's lymphoma Humans Iridium - chemistry Iridium - pharmacology Iridium - therapeutic use Iron - chemistry Iron - pharmacology Iron - therapeutic use Kinases Leukemia Lymphoma Medical research metal-based anticancer agents Metals - chemistry Metals - pharmacology Metals - therapeutic use Neoplasms - drug therapy Nitrogen Organometallic Compounds - chemistry Organometallic Compounds - pharmacology Organometallic Compounds - therapeutic use Ovarian cancer Pancreas Pancreatic cancer Prostate Rhenium - chemistry Rhenium - pharmacology Rhenium - therapeutic use Rhodium - chemistry Rhodium - pharmacology Rhodium - therapeutic use Ruthenium - chemistry Ruthenium - pharmacology Ruthenium - therapeutic use Success Testicular cancer Tumors Vitamin B
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