Nanocarrier-mediated Delivery of CORM-2 Enhances Anti-allodynic and Anti-hyperalgesic Effects of CORM-2

Neuropathic pain is a devastating chronic condition and effective treatments are still lacking. Carbon monoxide-releasing molecule-2 (CORM-2) as a carbon monoxide (CO) carrier, exerts potent anti-neuropathic pain effects; however, its poor water solubility and short half-life hinder its clinical uti...

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Veröffentlicht in:	Molecular neurobiology 2019-08, Vol.56 (8), p.5539-5554
Hauptverfasser:	Joshi, Hari Prasad, Kim, Sung Bum, Kim, Seungki, Kumar, Hemant, Jo, Min-Jae, Choi, Hyemin, Kim, Juri, Kyung, Jae Won, Sohn, Seil, Kim, Kyoung-Tae, Kim, Jin-Ki, Han, In-Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Calcium-Binding Proteins - metabolism Carbon monoxide Carbon Monoxide - metabolism Cell Biology Chronic illnesses Drug Carriers - chemistry Female Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Gene Expression Regulation - drug effects Glial fibrillary acidic protein Glial Fibrillary Acidic Protein - metabolism Heme Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hyperalgesia Hyperalgesia - drug therapy Hyperalgesia - pathology Inflammation Interleukin 10 Interleukin-10 - genetics Interleukin-10 - metabolism Lipids - chemistry Microfilament Proteins - metabolism Models, Biological Myoglobins Nanoparticles Nanoparticles - chemistry Neuralgia Neuralgia - complications Neuralgia - pathology Neurobiology Neurology Neurosciences Nitric oxide Nitric Oxide Synthase Type I - genetics Nitric Oxide Synthase Type I - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Organometallic Compounds - pharmacology Organometallic Compounds - therapeutic use Oxygenase Pain perception Polymerase chain reaction Rats, Sprague-Dawley RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Spinal cord Spinal Cord - pathology Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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