Identification and Quantification of (t)RNA Modifications in Pseudomonas aeruginosa by Liquid Chromatography–Tandem Mass Spectrometry

Transfer RNA (tRNA) modifications impact the structure and function of tRNAs, thus affecting the efficiency and fidelity of translation. In the opportunistic pathogen Pseudomonas aeruginosa translational regulation plays an important but less defined role in adaptation to changing environments. In t...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2019-06, Vol.20 (11), p.1430-1437
Hauptverfasser:	Grobe, Svenja, Doberenz, Sebastian, Ferreira, Kevin, Krueger, Jonas, Brönstrup, Mark, Kaever, Volkhard, Häussler, Susanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Changing environments Chromatography, Liquid - methods Gene expression Gene regulation Isoacceptors Liquid chromatography Mass spectrometry Mass spectroscopy Opportunist infection Pathogenicity Pathogens Pseudomonas aeruginosa Pseudomonas aeruginosa - genetics Ribonucleic acid Ribonucleosides - metabolism RNA RNA Processing, Post-Transcriptional RNA, Transfer - metabolism Structure-function relationships Tandem Mass Spectrometry - methods Transcription Transfer RNA tRNA tRNA modifications
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