Complete tumor response of a locally advanced lung large-cell neuroendocrine carcinoma after palliative thoracic radiotherapy and immunotherapy with nivolumab

•Complete tumor response of an L-LCNEC to radiotherapy and immunotherapy.•There is a possible synergetic effect of radiotherapy with immunotherapy.•Immunotherapy seems to be efficient in carcinoma-LCNEC.•Immunotherapy could be effective in the neoadjuvant setting in L-LCNEC. Lung large-cell neuroend...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2019-02, Vol.128, p.53-56
Hauptverfasser:	Mauclet, Charlotte, Duplaquet, Fabrice, Pirard, Lionel, Rondelet, Benoît, Dupont, Michael, Pop-Stanciu, Claudia, Vander Borght, Thierry, Remmelink, Myriam, D’Haene, Nicky, Lambin, Suzan, Wanet, Marie, Remouchamps, Vincent, Ocak, Sebahat
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Large Cell - diagnosis Carcinoma, Large Cell - therapy Carcinoma, Neuroendocrine - diagnosis Carcinoma, Neuroendocrine - therapy Combined Modality Therapy Female Humans Immunohistochemistry Locally advanced stage Lung large-cell neuroendocrine carcinoma Lung Neoplasms - diagnosis Lung Neoplasms - therapy Neoplasm Metastasis Neoplasm Staging Nivolumab - administration & dosage Palliative Care - methods PD-1 inhibitor Positron Emission Tomography Computed Tomography Radiation therapy Radiotherapy, Adjuvant Salvage surgery Synergistic effect
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