More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Background Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with perito...
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| Veröffentlicht in: | Annals of surgical oncology 2019-03, Vol.26 (3), p.845-851 |
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| container_title | Annals of surgical oncology |
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| creator | Solomon, Daniel DeNicola, Natasha L. Feferman, Yael Bekhor, Eliahu Reppucci, Marina L. Feingold, Daniela Aycart, Samantha N. Magge, Deepa R. Golas, Benjamin J. Labow, Daniel M. Sarpel, Umut |
| description | Background
Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with peritoneal carcinomatosis (PC) from CRC, although it has not been evaluated specifically in patients |
| doi_str_mv | 10.1245/s10434-018-07087-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2179345498</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2179345498</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-c64348a84177a0afb0af76f05aa212f00fc15558e42b8c6d2f05dedcafb8c1ce3</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhiNERUvhBTggS1y4BOzETpwjCtBWWtRKbQ-cLK8z2XWV2MF2FuUBea_OdguVOPRg2Zr_m39s_1n2jtFPrODic2SUlzynTOa0prLOmxfZCRNY4pVkL_FMK5k3RSWOs9cx3lHK6pKKV9lxSSteNg0_yf788AHI9eLMNnjn50iuINjkHeiBfLURdASynhNZebeBQK7nsLM71KwjP_38ULvSyYJLkfy2aUtaHYx1ftTJRxtJH_xIWj_gGJOwr9XOYM-t6yBsvHUb0i4JxW42ye5gPwA9F6JdR86XCULaQhitIRcuBT09Xa7dwuj3op6WN9lRr4cIbx_30-z2-7eb9jxfXZ5dtF9WuSlrkXKDr-ZSS87qWlPdr3HVVU-F1gUrekp7w4QQEnixlqbqsCQ66AyS0jAD5Wn28eA7Bf9rhpjUaKOBYdAO8O9Uweqm5II3EtEP_6F3fg4Ob4dUVUlZc8mRKg6UCT7GAL2agh11WBSjah-yOoSsMGT1ELJqsOn9o_W8HqH71_I3VQTKAxBR2kf0NPsZ23tflLi1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2166887484</pqid></control><display><type>article</type><title>More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy</title><source>SpringerLink Journals - AutoHoldings</source><creator>Solomon, Daniel ; DeNicola, Natasha L. ; Feferman, Yael ; Bekhor, Eliahu ; Reppucci, Marina L. ; Feingold, Daniela ; Aycart, Samantha N. ; Magge, Deepa R. ; Golas, Benjamin J. ; Labow, Daniel M. ; Sarpel, Umut</creator><creatorcontrib>Solomon, Daniel ; DeNicola, Natasha L. ; Feferman, Yael ; Bekhor, Eliahu ; Reppucci, Marina L. ; Feingold, Daniela ; Aycart, Samantha N. ; Magge, Deepa R. ; Golas, Benjamin J. ; Labow, Daniel M. ; Sarpel, Umut</creatorcontrib><description>Background
Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with peritoneal carcinomatosis (PC) from CRC, although it has not been evaluated specifically in patients < 50 years.
Methods
CRC patients aged < 50 years at diagnosis undergoing CRS/HIPEC 2007–2017 were compared with those aged ≥ 50 years. Age distribution was analyzed in patients undergoing colectomy alone versus CRS/HIPEC for CRC 1993–2013.
Results
A total of 98 patients underwent CRS/HIPEC, of which 44% were < 50 years. Younger patients were more likely to present with synchronous peritoneal metastases (
p
= 0.050). Receipt of perioperative chemotherapy was comparable (
p
= not significant [NS]). Charlson Comorbidity Index and ECOG score were similar (
p
= NS). Tumor grade was similar (
p
= NS). Peritoneal Carcinomatosis Index, total organs resected, and anastomoses created were comparable (
p
= NS). Major Clavien-Dindo morbidity and LOS were similar (
p
= NS). Younger patients survived longer after CRS/HIPEC (
p
= 0.011). Demographic data from patients undergoing colectomy (
n
= 225) and CRS/HIPEC (
n
= 98) showed that age < 50 years was increasingly common with the more aggressive procedure (9% and 44% respectively,
p
< 0.001).
Conclusions
Younger patients with PC from CRC presented more often with peritoneal metastases at the time of diagnosis. Yet despite similar perioperative features at CRS/HIPEC, they survived longer than older patients. Patients undergoing CRS/HIPEC are overall younger than those undergoing index colectomy.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-018-07087-9</identifier><identifier>PMID: 30643994</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Age composition ; Chemotherapy ; Colon ; Colorectal cancer ; Colorectal carcinoma ; Diagnosis ; Gastric cancer ; Gastrointestinal Oncology ; Medicine ; Medicine & Public Health ; Metastases ; Metastasis ; Morbidity ; Oncology ; Peritoneum ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2019-03, Vol.26 (3), p.845-851</ispartof><rights>Society of Surgical Oncology 2019</rights><rights>Annals of Surgical Oncology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-c64348a84177a0afb0af76f05aa212f00fc15558e42b8c6d2f05dedcafb8c1ce3</citedby><cites>FETCH-LOGICAL-c375t-c64348a84177a0afb0af76f05aa212f00fc15558e42b8c6d2f05dedcafb8c1ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-018-07087-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-018-07087-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30643994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solomon, Daniel</creatorcontrib><creatorcontrib>DeNicola, Natasha L.</creatorcontrib><creatorcontrib>Feferman, Yael</creatorcontrib><creatorcontrib>Bekhor, Eliahu</creatorcontrib><creatorcontrib>Reppucci, Marina L.</creatorcontrib><creatorcontrib>Feingold, Daniela</creatorcontrib><creatorcontrib>Aycart, Samantha N.</creatorcontrib><creatorcontrib>Magge, Deepa R.</creatorcontrib><creatorcontrib>Golas, Benjamin J.</creatorcontrib><creatorcontrib>Labow, Daniel M.</creatorcontrib><creatorcontrib>Sarpel, Umut</creatorcontrib><title>More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with peritoneal carcinomatosis (PC) from CRC, although it has not been evaluated specifically in patients < 50 years.
Methods
CRC patients aged < 50 years at diagnosis undergoing CRS/HIPEC 2007–2017 were compared with those aged ≥ 50 years. Age distribution was analyzed in patients undergoing colectomy alone versus CRS/HIPEC for CRC 1993–2013.
Results
A total of 98 patients underwent CRS/HIPEC, of which 44% were < 50 years. Younger patients were more likely to present with synchronous peritoneal metastases (
p
= 0.050). Receipt of perioperative chemotherapy was comparable (
p
= not significant [NS]). Charlson Comorbidity Index and ECOG score were similar (
p
= NS). Tumor grade was similar (
p
= NS). Peritoneal Carcinomatosis Index, total organs resected, and anastomoses created were comparable (
p
= NS). Major Clavien-Dindo morbidity and LOS were similar (
p
= NS). Younger patients survived longer after CRS/HIPEC (
p
= 0.011). Demographic data from patients undergoing colectomy (
n
= 225) and CRS/HIPEC (
n
= 98) showed that age < 50 years was increasingly common with the more aggressive procedure (9% and 44% respectively,
p
< 0.001).
Conclusions
Younger patients with PC from CRC presented more often with peritoneal metastases at the time of diagnosis. Yet despite similar perioperative features at CRS/HIPEC, they survived longer than older patients. Patients undergoing CRS/HIPEC are overall younger than those undergoing index colectomy.</description><subject>Age composition</subject><subject>Chemotherapy</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diagnosis</subject><subject>Gastric cancer</subject><subject>Gastrointestinal Oncology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Morbidity</subject><subject>Oncology</subject><subject>Peritoneum</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kcFu1DAQhiNERUvhBTggS1y4BOzETpwjCtBWWtRKbQ-cLK8z2XWV2MF2FuUBea_OdguVOPRg2Zr_m39s_1n2jtFPrODic2SUlzynTOa0prLOmxfZCRNY4pVkL_FMK5k3RSWOs9cx3lHK6pKKV9lxSSteNg0_yf788AHI9eLMNnjn50iuINjkHeiBfLURdASynhNZebeBQK7nsLM71KwjP_38ULvSyYJLkfy2aUtaHYx1ftTJRxtJH_xIWj_gGJOwr9XOYM-t6yBsvHUb0i4JxW42ye5gPwA9F6JdR86XCULaQhitIRcuBT09Xa7dwuj3op6WN9lRr4cIbx_30-z2-7eb9jxfXZ5dtF9WuSlrkXKDr-ZSS87qWlPdr3HVVU-F1gUrekp7w4QQEnixlqbqsCQ66AyS0jAD5Wn28eA7Bf9rhpjUaKOBYdAO8O9Uweqm5II3EtEP_6F3fg4Ob4dUVUlZc8mRKg6UCT7GAL2agh11WBSjah-yOoSsMGT1ELJqsOn9o_W8HqH71_I3VQTKAxBR2kf0NPsZ23tflLi1</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Solomon, Daniel</creator><creator>DeNicola, Natasha L.</creator><creator>Feferman, Yael</creator><creator>Bekhor, Eliahu</creator><creator>Reppucci, Marina L.</creator><creator>Feingold, Daniela</creator><creator>Aycart, Samantha N.</creator><creator>Magge, Deepa R.</creator><creator>Golas, Benjamin J.</creator><creator>Labow, Daniel M.</creator><creator>Sarpel, Umut</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20190301</creationdate><title>More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy</title><author>Solomon, Daniel ; DeNicola, Natasha L. ; Feferman, Yael ; Bekhor, Eliahu ; Reppucci, Marina L. ; Feingold, Daniela ; Aycart, Samantha N. ; Magge, Deepa R. ; Golas, Benjamin J. ; Labow, Daniel M. ; Sarpel, Umut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c64348a84177a0afb0af76f05aa212f00fc15558e42b8c6d2f05dedcafb8c1ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Age composition</topic><topic>Chemotherapy</topic><topic>Colon</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Diagnosis</topic><topic>Gastric cancer</topic><topic>Gastrointestinal Oncology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Morbidity</topic><topic>Oncology</topic><topic>Peritoneum</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solomon, Daniel</creatorcontrib><creatorcontrib>DeNicola, Natasha L.</creatorcontrib><creatorcontrib>Feferman, Yael</creatorcontrib><creatorcontrib>Bekhor, Eliahu</creatorcontrib><creatorcontrib>Reppucci, Marina L.</creatorcontrib><creatorcontrib>Feingold, Daniela</creatorcontrib><creatorcontrib>Aycart, Samantha N.</creatorcontrib><creatorcontrib>Magge, Deepa R.</creatorcontrib><creatorcontrib>Golas, Benjamin J.</creatorcontrib><creatorcontrib>Labow, Daniel M.</creatorcontrib><creatorcontrib>Sarpel, Umut</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solomon, Daniel</au><au>DeNicola, Natasha L.</au><au>Feferman, Yael</au><au>Bekhor, Eliahu</au><au>Reppucci, Marina L.</au><au>Feingold, Daniela</au><au>Aycart, Samantha N.</au><au>Magge, Deepa R.</au><au>Golas, Benjamin J.</au><au>Labow, Daniel M.</au><au>Sarpel, Umut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2019-03-01</date><risdate>2019</risdate><volume>26</volume><issue>3</issue><spage>845</spage><epage>851</epage><pages>845-851</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Colonoscopy to detect colorectal cancer (CRC) is recommended starting at age 50 years; however, CRC rates are increasing in the prescreening population. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has been proven effective in select patients with peritoneal carcinomatosis (PC) from CRC, although it has not been evaluated specifically in patients < 50 years.
Methods
CRC patients aged < 50 years at diagnosis undergoing CRS/HIPEC 2007–2017 were compared with those aged ≥ 50 years. Age distribution was analyzed in patients undergoing colectomy alone versus CRS/HIPEC for CRC 1993–2013.
Results
A total of 98 patients underwent CRS/HIPEC, of which 44% were < 50 years. Younger patients were more likely to present with synchronous peritoneal metastases (
p
= 0.050). Receipt of perioperative chemotherapy was comparable (
p
= not significant [NS]). Charlson Comorbidity Index and ECOG score were similar (
p
= NS). Tumor grade was similar (
p
= NS). Peritoneal Carcinomatosis Index, total organs resected, and anastomoses created were comparable (
p
= NS). Major Clavien-Dindo morbidity and LOS were similar (
p
= NS). Younger patients survived longer after CRS/HIPEC (
p
= 0.011). Demographic data from patients undergoing colectomy (
n
= 225) and CRS/HIPEC (
n
= 98) showed that age < 50 years was increasingly common with the more aggressive procedure (9% and 44% respectively,
p
< 0.001).
Conclusions
Younger patients with PC from CRC presented more often with peritoneal metastases at the time of diagnosis. Yet despite similar perioperative features at CRS/HIPEC, they survived longer than older patients. Patients undergoing CRS/HIPEC are overall younger than those undergoing index colectomy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30643994</pmid><doi>10.1245/s10434-018-07087-9</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2019-03, Vol.26 (3), p.845-851 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2179345498 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Age composition Chemotherapy Colon Colorectal cancer Colorectal carcinoma Diagnosis Gastric cancer Gastrointestinal Oncology Medicine Medicine & Public Health Metastases Metastasis Morbidity Oncology Peritoneum Surgery Surgical Oncology |
| title | More Synchronous Peritoneal Disease but Longer Survival in Younger Patients with Carcinomatosis from Colorectal Cancer Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy |
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