Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model

•Activation of IRF8 was involved in the development of pain-induced depression.•Intrathecal injection of IRF8 decreased IRF8 in the spinal cord and BDNF in NAc.•PRF on DRG decreased IRF8 in the spinal cord and BDNF in NAc.•PRF on DRG contributed to attenuate of the neuropathic pain-induced depressio...

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Veröffentlicht in:	Brain research bulletin 2019-03, Vol.146, p.192-200
Hauptverfasser:	Fang, Xiangyu, Xu, Xueru, Lin, Xingwu, Liu, Rongguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism Depression Depression - metabolism Depression - psychology Depression - therapy Depressive Disorder - metabolism Depressive Disorder - psychology Depressive Disorder - therapy Disease Models, Animal Dorsal root ganglion Ganglia, Spinal - metabolism Interferon regulatory factor 8 Interferon Regulatory Factors - administration & dosage Interferon Regulatory Factors - metabolism Male Neuralgia - metabolism Neuralgia - psychology Neuralgia - therapy Neuropathic pain Nucleus Accumbens - metabolism Peripheral Nerve Injuries - metabolism Pulsed Radiofrequency Treatment - methods Pulsed radiofrequency Rats Rats, Wistar Sciatic Nerve - metabolism
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