Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma
This study was designed as a retrospective observational study, focusing on the correlation between the preoperative CT-scan tumor volume, tumor sphericity, and the disease-related prognosis. A total of 30 consecutive patients, affected by primary oral cancer, were retrospectively identified from ou...
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| Veröffentlicht in: | Journal of cranio-maxillo-facial surgery 2019-03, Vol.47 (3), p.510-515 |
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| creator | Tarsitano, Achille Ricotta, Francesco Cercenelli, Laura Bortolani, Barbara Battaglia, Salvatore Lucchi, Elisabetta Marchetti, Claudio Marcelli, Emanuela |
| description | This study was designed as a retrospective observational study, focusing on the correlation between the preoperative CT-scan tumor volume, tumor sphericity, and the disease-related prognosis.
A total of 30 consecutive patients, affected by primary oral cancer, were retrospectively identified from our oral cancer database. The preoperative images (DICOM data) for the study population were uploaded into a modular software package designed to convert patients' medical images into 3D digital models. Multislice interpolation and threshold segmentation tools were used to segment the tumor mass. This was then converted into a 3D mesh and exported in STL format, in order to calculate the corresponding volume. We applied the concept of sphericity — a measurement of how closely the shape of an object approaches that of a mathematically perfect sphere — to the segmented tumor mass.
Mean tumor volume was larger in patients with tumor recurrence and/or who had died than in patients who were disease free/alive. Tumor sphericity was influential on clinical outcomes. It appeared to be lower in patients who had tumor recurrence and/or who had died (0.54 ± 0.09 and 0.53 ± 0.05) than in patients who were disease free/alive (0.65 ± 0.07). This difference was statistically significant (p |
| doi_str_mv | 10.1016/j.jcms.2018.12.019 |
| format | Article |
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A total of 30 consecutive patients, affected by primary oral cancer, were retrospectively identified from our oral cancer database. The preoperative images (DICOM data) for the study population were uploaded into a modular software package designed to convert patients' medical images into 3D digital models. Multislice interpolation and threshold segmentation tools were used to segment the tumor mass. This was then converted into a 3D mesh and exported in STL format, in order to calculate the corresponding volume. We applied the concept of sphericity — a measurement of how closely the shape of an object approaches that of a mathematically perfect sphere — to the segmented tumor mass.
Mean tumor volume was larger in patients with tumor recurrence and/or who had died than in patients who were disease free/alive. Tumor sphericity was influential on clinical outcomes. It appeared to be lower in patients who had tumor recurrence and/or who had died (0.54 ± 0.09 and 0.53 ± 0.05) than in patients who were disease free/alive (0.65 ± 0.07). This difference was statistically significant (p < 0.05). Cumulative recurrence-free survival was 86.2% for patients with a tumor volume lower than the cut-off value. Otherwise, it was 0% for those with a tumor volume higher than the cut-off value (p < 0.01; log rank test). Cumulative recurrence-free survival was 86.3% for patients with a higher sphericity index, compared with 13.6% for those with a lower sphericity index.
The prognostic model, based on a tridimensional, CT-based characterization of the tumor size, which includes both tumor volume and tumor sphericity, uses readily available information and could be considered when formulating prognoses for patients with oral cancer.</description><identifier>ISSN: 1010-5182</identifier><identifier>EISSN: 1878-4119</identifier><identifier>DOI: 10.1016/j.jcms.2018.12.019</identifier><identifier>PMID: 30642733</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>3D imaging ; Aged ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Mouth Neoplasms - diagnostic imaging ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Neoplasm Recurrence, Local ; Oral squamous cell carcinoma ; Prognosis ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed ; Tumor Burden ; Tumor sphericity ; Tumor volume</subject><ispartof>Journal of cranio-maxillo-facial surgery, 2019-03, Vol.47 (3), p.510-515</ispartof><rights>2019 European Association for Cranio-Maxillo-Facial Surgery</rights><rights>Copyright © 2019 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b635b394b183ed2ddbf720115b79cb7a083899f2885d5ddb15b2262c7c96e4c83</citedby><cites>FETCH-LOGICAL-c356t-b635b394b183ed2ddbf720115b79cb7a083899f2885d5ddb15b2262c7c96e4c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcms.2018.12.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30642733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tarsitano, Achille</creatorcontrib><creatorcontrib>Ricotta, Francesco</creatorcontrib><creatorcontrib>Cercenelli, Laura</creatorcontrib><creatorcontrib>Bortolani, Barbara</creatorcontrib><creatorcontrib>Battaglia, Salvatore</creatorcontrib><creatorcontrib>Lucchi, Elisabetta</creatorcontrib><creatorcontrib>Marchetti, Claudio</creatorcontrib><creatorcontrib>Marcelli, Emanuela</creatorcontrib><title>Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma</title><title>Journal of cranio-maxillo-facial surgery</title><addtitle>J Craniomaxillofac Surg</addtitle><description>This study was designed as a retrospective observational study, focusing on the correlation between the preoperative CT-scan tumor volume, tumor sphericity, and the disease-related prognosis.
A total of 30 consecutive patients, affected by primary oral cancer, were retrospectively identified from our oral cancer database. The preoperative images (DICOM data) for the study population were uploaded into a modular software package designed to convert patients' medical images into 3D digital models. Multislice interpolation and threshold segmentation tools were used to segment the tumor mass. This was then converted into a 3D mesh and exported in STL format, in order to calculate the corresponding volume. We applied the concept of sphericity — a measurement of how closely the shape of an object approaches that of a mathematically perfect sphere — to the segmented tumor mass.
Mean tumor volume was larger in patients with tumor recurrence and/or who had died than in patients who were disease free/alive. Tumor sphericity was influential on clinical outcomes. It appeared to be lower in patients who had tumor recurrence and/or who had died (0.54 ± 0.09 and 0.53 ± 0.05) than in patients who were disease free/alive (0.65 ± 0.07). This difference was statistically significant (p < 0.05). Cumulative recurrence-free survival was 86.2% for patients with a tumor volume lower than the cut-off value. Otherwise, it was 0% for those with a tumor volume higher than the cut-off value (p < 0.01; log rank test). Cumulative recurrence-free survival was 86.3% for patients with a higher sphericity index, compared with 13.6% for those with a lower sphericity index.
The prognostic model, based on a tridimensional, CT-based characterization of the tumor size, which includes both tumor volume and tumor sphericity, uses readily available information and could be considered when formulating prognoses for patients with oral cancer.</description><subject>3D imaging</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Mouth Neoplasms - diagnostic imaging</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Recurrence, Local</subject><subject>Oral squamous cell carcinoma</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumor Burden</subject><subject>Tumor sphericity</subject><subject>Tumor volume</subject><issn>1010-5182</issn><issn>1878-4119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0E4v0DLJCXbBL8aBJbYoMQL6kSLGBtOc4EXNVxsZ2i_j2OWliysjVz586dg9AFJSUltL5elAvjYskIFSVlJaFyDx1T0YhiRqncz39CSVFRwY7QSYwLQkhNhDxER5zUM9Zwfow2rwFSAJ0cDAmn0fmA1345OsB66HaFuPqEYI1NG6wjXgX_MfiYrMG9NsmHiO2AVzrZbBHxt02f2Ae9xEavp5H4NWrnx4gNLKdiMHbwTp-hg14vI5zv3lP0_nD_dvdUzF8en-9u54XhVZ2KtuZVy-WspYJDx7qu7Zt8Ma3aRpq20URwIWXPhKi6Kndzg7GamcbIGmZG8FN0tfXNub9GiEk5G6coeoCcSjHaSJ4XVFWWsq3UBB9jgF6tgnU6bBQlakKuFmpCribkijKVkeehy53_2Dro_kZ-GWfBzVYA-cq1haCiyagMdDaASarz9j__H5wglVU</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Tarsitano, Achille</creator><creator>Ricotta, Francesco</creator><creator>Cercenelli, Laura</creator><creator>Bortolani, Barbara</creator><creator>Battaglia, Salvatore</creator><creator>Lucchi, Elisabetta</creator><creator>Marchetti, Claudio</creator><creator>Marcelli, Emanuela</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201903</creationdate><title>Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma</title><author>Tarsitano, Achille ; Ricotta, Francesco ; Cercenelli, Laura ; Bortolani, Barbara ; Battaglia, Salvatore ; Lucchi, Elisabetta ; Marchetti, Claudio ; Marcelli, Emanuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b635b394b183ed2ddbf720115b79cb7a083899f2885d5ddb15b2262c7c96e4c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>3D imaging</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Mouth Neoplasms - diagnostic imaging</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Recurrence, Local</topic><topic>Oral squamous cell carcinoma</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumor Burden</topic><topic>Tumor sphericity</topic><topic>Tumor volume</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarsitano, Achille</creatorcontrib><creatorcontrib>Ricotta, Francesco</creatorcontrib><creatorcontrib>Cercenelli, Laura</creatorcontrib><creatorcontrib>Bortolani, Barbara</creatorcontrib><creatorcontrib>Battaglia, Salvatore</creatorcontrib><creatorcontrib>Lucchi, Elisabetta</creatorcontrib><creatorcontrib>Marchetti, Claudio</creatorcontrib><creatorcontrib>Marcelli, Emanuela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cranio-maxillo-facial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tarsitano, Achille</au><au>Ricotta, Francesco</au><au>Cercenelli, Laura</au><au>Bortolani, Barbara</au><au>Battaglia, Salvatore</au><au>Lucchi, Elisabetta</au><au>Marchetti, Claudio</au><au>Marcelli, Emanuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma</atitle><jtitle>Journal of cranio-maxillo-facial surgery</jtitle><addtitle>J Craniomaxillofac Surg</addtitle><date>2019-03</date><risdate>2019</risdate><volume>47</volume><issue>3</issue><spage>510</spage><epage>515</epage><pages>510-515</pages><issn>1010-5182</issn><eissn>1878-4119</eissn><abstract>This study was designed as a retrospective observational study, focusing on the correlation between the preoperative CT-scan tumor volume, tumor sphericity, and the disease-related prognosis.
A total of 30 consecutive patients, affected by primary oral cancer, were retrospectively identified from our oral cancer database. The preoperative images (DICOM data) for the study population were uploaded into a modular software package designed to convert patients' medical images into 3D digital models. Multislice interpolation and threshold segmentation tools were used to segment the tumor mass. This was then converted into a 3D mesh and exported in STL format, in order to calculate the corresponding volume. We applied the concept of sphericity — a measurement of how closely the shape of an object approaches that of a mathematically perfect sphere — to the segmented tumor mass.
Mean tumor volume was larger in patients with tumor recurrence and/or who had died than in patients who were disease free/alive. Tumor sphericity was influential on clinical outcomes. It appeared to be lower in patients who had tumor recurrence and/or who had died (0.54 ± 0.09 and 0.53 ± 0.05) than in patients who were disease free/alive (0.65 ± 0.07). This difference was statistically significant (p < 0.05). Cumulative recurrence-free survival was 86.2% for patients with a tumor volume lower than the cut-off value. Otherwise, it was 0% for those with a tumor volume higher than the cut-off value (p < 0.01; log rank test). Cumulative recurrence-free survival was 86.3% for patients with a higher sphericity index, compared with 13.6% for those with a lower sphericity index.
The prognostic model, based on a tridimensional, CT-based characterization of the tumor size, which includes both tumor volume and tumor sphericity, uses readily available information and could be considered when formulating prognoses for patients with oral cancer.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>30642733</pmid><doi>10.1016/j.jcms.2018.12.019</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of cranio-maxillo-facial surgery, 2019-03, Vol.47 (3), p.510-515 |
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| subjects | 3D imaging Aged Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Disease-Free Survival Female Humans Kaplan-Meier Estimate Male Mouth Neoplasms - diagnostic imaging Mouth Neoplasms - mortality Mouth Neoplasms - pathology Neoplasm Recurrence, Local Oral squamous cell carcinoma Prognosis Retrospective Studies Survival Rate Tomography, X-Ray Computed Tumor Burden Tumor sphericity Tumor volume |
| title | Pretreatment tumor volume and tumor sphericity as prognostic factors in patients with oral cavity squamous cell carcinoma |
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