Geniposide regulates the miR-101/MKP-1/p38 pathway and alleviates atherosclerosis inflammatory injury in ApoE-/- mice

•Geniposide ameliorates hepatocyte fatty degeneration and increases plaque stability.•Geniposide regulates the expression of certain miRNAs in inflammation.•Geniposide increases the protein expression of MKP-1, a target of miR-101, in ApoE−/− mice and Raw264.7 cells induced by LPS.•Geniposide downre...

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Veröffentlicht in:	Immunobiology (1979) 2019-03, Vol.224 (2), p.296-306
Hauptverfasser:	Cheng, Saibo, Zhou, Fenghua, Xu, Yuling, Liu, Xiaoyu, Zhang, Yu, Gu, Minhua, Su, Zhijie, Zhao, Dandan, Zhang, Lei, Jia, Yuhua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - deficiency Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Cytokines - metabolism Disease Models, Animal Dual Specificity Phosphatase 1 - genetics Genetic Predisposition to Disease Geniposide Inflammation Iridoids - pharmacology Lipid Metabolism Mice Mice, Knockout MicroRNAs MicroRNAs - genetics MKP-1 p38 Mitogen-Activated Protein Kinases - genetics RAW 264.7 Cells Signal Transduction
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