L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents

•Delivery of L-AAA to the PLC of Wistar rats produced an increase in immobility in the FST.•Intra hippocampal CA3 L-AAA delivery produced a deficit in the novel object relocation task.•A single dose of L-AAA to the PLC of mice provokes an increase in immobility in the FST.•L-AAA provokes a reduction...

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Veröffentlicht in:	Behavioural brain research 2019-04, Vol.362, p.90-102
Hauptverfasser:	David, J., Gormley, S., McIntosh, A.L., Kebede, V., Thuery, G., Varidaki, A., Coffey, E.T., Harkin, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytes Dendritic spine density Forced swimming test L-alpha-aminoadipic acid Pre-limbic cortex Stress
Online-Zugang:	Volltext
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