Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study

Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Their real-life evaluation is insufficient, especially in elderly and frail patients. The aim was to describe use, safety, and effectiveness of targeted therapies in first-line mCRC treatment according to age. Two...

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Veröffentlicht in:	Clinical colorectal cancer 2019-03, Vol.18 (1), p.e150-e162
Hauptverfasser:	Gouverneur, Amandine, Coutureau, Juliette, Jové, Jérémy, Rouyer, Magali, Grelaud, Angela, Duc, Sophie, Gérard, Stéphane, Smith, Denis, Ravaud, Alain, Droz, Cécile, Bernard, Marie-Agnès, Lassalle, Régis, Forrier-Réglat, Annie, Noize, Pernelle, Smith, D., Tubiana-Mathieu, N., Michel, P., Guimbaud, R., Becouarn, Y., Viret, F., Larregain-Fournier, D., Botreau, Y., Texereau, P., Auby, D., Gautier-Felizot, L., Loury-Larivière, I., Brudieux, E., Cany, L., Lecaille, C., Jaubert, D., Guichard, P., Bernard, O., Vives, L., Taoubi, N., Martinez, M., Burki, F., Roque, I., Thouveny, F., Gaspard, M.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Colorectal neoplasm Frail elderly Molecular targeted therapy Neoplasm metastasis
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Zusammenfassung:	Metastatic colorectal cancer (mCRC) is increasingly treated using targeted therapies. Their real-life evaluation is insufficient, especially in elderly and frail patients. The aim was to describe use, safety, and effectiveness of targeted therapies in first-line mCRC treatment according to age. Two field cohorts of patients initiating bevacizumab or cetuximab for first-line mCRC were pooled. Patients characteristics, use, and safety were compared between younger and elderly patients (
ISSN:	1533-0028 1938-0674
DOI:	10.1016/j.clcc.2018.11.005