Antenatal hydronephrosis and fetal urine sampling
The aim of this study is to evaluate the significance of renal pelvis aspiration (RPA) in the management of antenatal hydronephrosis (AHN). This study enrolled 15 AHN cases (one twin pregnancy) that necessitated RPA for AHN. Chromosomal abnormalities, gene disorders, and additional life‐threatening...
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| Veröffentlicht in: | Congenital anomalies 2020-01, Vol.60 (1), p.4-9 |
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| container_title | Congenital anomalies |
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| creator | Beksac, Mehmet Sinan Beksac, Alp Tuna Tanacan, Atakan Mumusoglu, Sezcan Katlan, Doruk Celik, Hasan Tolga |
| description | The aim of this study is to evaluate the significance of renal pelvis aspiration (RPA) in the management of antenatal hydronephrosis (AHN). This study enrolled 15 AHN cases (one twin pregnancy) that necessitated RPA for AHN. Chromosomal abnormalities, gene disorders, and additional life‐threatening congenital abnormalities were eliminated prior to intrauterine interventions. Urine analysis were performed for the evaluation of renal function. Normal renal function was observed in six neonates/infants (40%) (group 1), whereas impaired renal function and various type of urinary system anomalies were observed in 9 neonates/infants (60%) (group 2) during the short‐term and longitudinal follow‐up periods. There were statistically significant differences in the oligohydroamniosis rate, mean fetal urine sodium value, mean fetal urine β2‐microglobulin, mean gestational week at birth, and mean birthweight values between the groups (P = 0.007, P |
| doi_str_mv | 10.1111/cga.12324 |
| format | Article |
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This study enrolled 15 AHN cases (one twin pregnancy) that necessitated RPA for AHN. Chromosomal abnormalities, gene disorders, and additional life‐threatening congenital abnormalities were eliminated prior to intrauterine interventions. Urine analysis were performed for the evaluation of renal function. Normal renal function was observed in six neonates/infants (40%) (group 1), whereas impaired renal function and various type of urinary system anomalies were observed in 9 neonates/infants (60%) (group 2) during the short‐term and longitudinal follow‐up periods. There were statistically significant differences in the oligohydroamniosis rate, mean fetal urine sodium value, mean fetal urine β2‐microglobulin, mean gestational week at birth, and mean birthweight values between the groups (P = 0.007, P < 0.001, P = 0.035, P < 0.001, and P = 0.001, respectively). Renal pelvis aspiration and urine analysis were substantial for the management of AHN in necessary cases. β2‐microglobulin and sodium are clinically useful markers to detect the presence of severe renal damage due to obstructive uropathy and thus, important adjuvants in the proper selection of fetuses for further antenatal interventions.</description><identifier>ISSN: 0914-3505</identifier><identifier>EISSN: 1741-4520</identifier><identifier>DOI: 10.1111/cga.12324</identifier><identifier>PMID: 30629771</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Abnormalities ; Adjuvants ; Anomalies ; antenatal hydronephrosis ; Birth weight ; congenital abnormality ; fetal urine sampling ; Fetuses ; Infants ; Neonates ; Pelvis ; Pregnancy ; Renal function ; Sodium ; Statistical analysis ; Urine</subject><ispartof>Congenital anomalies, 2020-01, Vol.60 (1), p.4-9</ispartof><rights>2019 Japanese Teratology Society</rights><rights>2019 Japanese Teratology Society.</rights><rights>2020 Japanese Teratology Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3734-65398736b1b94f0766fbf123a7c4b76d43657dde19b67232990a45987bad8473</citedby><cites>FETCH-LOGICAL-c3734-65398736b1b94f0766fbf123a7c4b76d43657dde19b67232990a45987bad8473</cites><orcidid>0000-0001-8209-8248</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcga.12324$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcga.12324$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30629771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beksac, Mehmet Sinan</creatorcontrib><creatorcontrib>Beksac, Alp Tuna</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Mumusoglu, Sezcan</creatorcontrib><creatorcontrib>Katlan, Doruk</creatorcontrib><creatorcontrib>Celik, Hasan Tolga</creatorcontrib><title>Antenatal hydronephrosis and fetal urine sampling</title><title>Congenital anomalies</title><addtitle>Congenit Anom (Kyoto)</addtitle><description>The aim of this study is to evaluate the significance of renal pelvis aspiration (RPA) in the management of antenatal hydronephrosis (AHN). This study enrolled 15 AHN cases (one twin pregnancy) that necessitated RPA for AHN. Chromosomal abnormalities, gene disorders, and additional life‐threatening congenital abnormalities were eliminated prior to intrauterine interventions. Urine analysis were performed for the evaluation of renal function. Normal renal function was observed in six neonates/infants (40%) (group 1), whereas impaired renal function and various type of urinary system anomalies were observed in 9 neonates/infants (60%) (group 2) during the short‐term and longitudinal follow‐up periods. There were statistically significant differences in the oligohydroamniosis rate, mean fetal urine sodium value, mean fetal urine β2‐microglobulin, mean gestational week at birth, and mean birthweight values between the groups (P = 0.007, P < 0.001, P = 0.035, P < 0.001, and P = 0.001, respectively). Renal pelvis aspiration and urine analysis were substantial for the management of AHN in necessary cases. β2‐microglobulin and sodium are clinically useful markers to detect the presence of severe renal damage due to obstructive uropathy and thus, important adjuvants in the proper selection of fetuses for further antenatal interventions.</description><subject>Abnormalities</subject><subject>Adjuvants</subject><subject>Anomalies</subject><subject>antenatal hydronephrosis</subject><subject>Birth weight</subject><subject>congenital abnormality</subject><subject>fetal urine sampling</subject><subject>Fetuses</subject><subject>Infants</subject><subject>Neonates</subject><subject>Pelvis</subject><subject>Pregnancy</subject><subject>Renal function</subject><subject>Sodium</subject><subject>Statistical analysis</subject><subject>Urine</subject><issn>0914-3505</issn><issn>1741-4520</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kD9PwzAQxS0EglIY-AIoEgsMaf3_6rGqoCBVYuluOYnTpkqcYDdC_fa4pDAgccsN97un9x5CdwRPSJxpvjETQhnlZ2hEgJOUC4rP0QgrwlMmsLhC1yHsMKZSAr5EVwxLqgDICJG521tn9qZOtofCt852W9-GKiTGFUlpj4feV84mwTRdXbnNDbooTR3s7WmP0frleb14TVfvy7fFfJXmDBhPpWBqBkxmJFO8xCBlmZXRpIGcZyALzqSAorBEZRKid6Ww4SK-ZKaYcWBj9DjIdr796G3Y66YKua1r42zbB00JqJiYAInowx901_beRXOaMkYkzISgkXoaqDzmC96WuvNVY_xBE6yPNepYo_6uMbL3J8U-a2zxS_70FoHpAHxWtT38r6QXy_kg-QXep3jC</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Beksac, Mehmet Sinan</creator><creator>Beksac, Alp Tuna</creator><creator>Tanacan, Atakan</creator><creator>Mumusoglu, Sezcan</creator><creator>Katlan, Doruk</creator><creator>Celik, Hasan Tolga</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8209-8248</orcidid></search><sort><creationdate>202001</creationdate><title>Antenatal hydronephrosis and fetal urine sampling</title><author>Beksac, Mehmet Sinan ; Beksac, Alp Tuna ; Tanacan, Atakan ; Mumusoglu, Sezcan ; Katlan, Doruk ; Celik, Hasan Tolga</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3734-65398736b1b94f0766fbf123a7c4b76d43657dde19b67232990a45987bad8473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Adjuvants</topic><topic>Anomalies</topic><topic>antenatal hydronephrosis</topic><topic>Birth weight</topic><topic>congenital abnormality</topic><topic>fetal urine sampling</topic><topic>Fetuses</topic><topic>Infants</topic><topic>Neonates</topic><topic>Pelvis</topic><topic>Pregnancy</topic><topic>Renal function</topic><topic>Sodium</topic><topic>Statistical analysis</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beksac, Mehmet Sinan</creatorcontrib><creatorcontrib>Beksac, Alp Tuna</creatorcontrib><creatorcontrib>Tanacan, Atakan</creatorcontrib><creatorcontrib>Mumusoglu, Sezcan</creatorcontrib><creatorcontrib>Katlan, Doruk</creatorcontrib><creatorcontrib>Celik, Hasan Tolga</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Congenital anomalies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beksac, Mehmet Sinan</au><au>Beksac, Alp Tuna</au><au>Tanacan, Atakan</au><au>Mumusoglu, Sezcan</au><au>Katlan, Doruk</au><au>Celik, Hasan Tolga</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antenatal hydronephrosis and fetal urine sampling</atitle><jtitle>Congenital anomalies</jtitle><addtitle>Congenit Anom (Kyoto)</addtitle><date>2020-01</date><risdate>2020</risdate><volume>60</volume><issue>1</issue><spage>4</spage><epage>9</epage><pages>4-9</pages><issn>0914-3505</issn><eissn>1741-4520</eissn><abstract>The aim of this study is to evaluate the significance of renal pelvis aspiration (RPA) in the management of antenatal hydronephrosis (AHN). This study enrolled 15 AHN cases (one twin pregnancy) that necessitated RPA for AHN. Chromosomal abnormalities, gene disorders, and additional life‐threatening congenital abnormalities were eliminated prior to intrauterine interventions. Urine analysis were performed for the evaluation of renal function. Normal renal function was observed in six neonates/infants (40%) (group 1), whereas impaired renal function and various type of urinary system anomalies were observed in 9 neonates/infants (60%) (group 2) during the short‐term and longitudinal follow‐up periods. There were statistically significant differences in the oligohydroamniosis rate, mean fetal urine sodium value, mean fetal urine β2‐microglobulin, mean gestational week at birth, and mean birthweight values between the groups (P = 0.007, P < 0.001, P = 0.035, P < 0.001, and P = 0.001, respectively). Renal pelvis aspiration and urine analysis were substantial for the management of AHN in necessary cases. β2‐microglobulin and sodium are clinically useful markers to detect the presence of severe renal damage due to obstructive uropathy and thus, important adjuvants in the proper selection of fetuses for further antenatal interventions.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>30629771</pmid><doi>10.1111/cga.12324</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8209-8248</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Abnormalities Adjuvants Anomalies antenatal hydronephrosis Birth weight congenital abnormality fetal urine sampling Fetuses Infants Neonates Pelvis Pregnancy Renal function Sodium Statistical analysis Urine |
| title | Antenatal hydronephrosis and fetal urine sampling |
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