Effect of instrumentation systems on endotoxin reduction from root canal systems: A systematic review of clinical studies and meta‐analysis

This systematic review assessed the effect of different root canal instrumentation systems on endotoxin reduction from the root canal system. The literature search was conducted in two electronic databases (PubMed and Scopus) using specific key words. The search strategy followed the PRISMA guidelin...

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Veröffentlicht in:Australian endodontic journal 2019-12, Vol.45 (3), p.407-413
Hauptverfasser: Neelakantan, Prasanna, Ahmed, Hany Mohamed Aly, Chang, Jeffrey Wen Wei, Nabhan, Mohamed Shady, Wei, Xi, Cheung, Gary Shun Pan, Gomes, Brenda P. F. A.
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container_end_page 413
container_issue 3
container_start_page 407
container_title Australian endodontic journal
container_volume 45
creator Neelakantan, Prasanna
Ahmed, Hany Mohamed Aly
Chang, Jeffrey Wen Wei
Nabhan, Mohamed Shady
Wei, Xi
Cheung, Gary Shun Pan
Gomes, Brenda P. F. A.
description This systematic review assessed the effect of different root canal instrumentation systems on endotoxin reduction from the root canal system. The literature search was conducted in two electronic databases (PubMed and Scopus) using specific key words. The search strategy followed the PRISMA guidelines. Qualitative synthesis and quantitative synthesis of the data were performed and data interpretation was done based on the guidelines in the Cochrane Handbook. The risk of bias was assessed using Cochrane criteria. The initial search yielded 600 citations, of which three papers met the criteria for inclusion in this review. Studies showed a significant reduction in endotoxin following rotary and reciprocating instrumentation, with no significant differences between them. The meta‐analysis showed no statistical significant difference between reciprocation and rotary files (P > 0.05). In conclusion, the instrumentation techniques compared in this review decrease endotoxin content from root canals, with no significant difference between them.
doi_str_mv 10.1111/aej.12333
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source MEDLINE; Wiley Journals
subjects Dental Pulp Cavity
Endodontics
endotoxin
Endotoxins
kinetic chromogenic limulus amebocyte lysate assay
lipopolysaccharide
Meta-analysis
reciprocation
Reviews
Root Canal Preparation
Root Canal Therapy
Root canals
rotary
Statistical analysis
Systematic review
title Effect of instrumentation systems on endotoxin reduction from root canal systems: A systematic review of clinical studies and meta‐analysis
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