Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC

Cytochromes P450 (CYPs) catalyze various oxidative transformations in drug metabolism, xenobiotic degradation, and natural product biosynthesis. Here we report biochemical, structural, and theoretical studies of TxtC, an unusual bifunctional CYP involved in the biosynthesis of the EPA-approved herbi...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-01, Vol.141 (1), p.216-222
Hauptverfasser:	Alkhalaf, Lona M, Barry, Sarah M, Rea, Dean, Gallo, Angelo, Griffiths, Daniel, Lewandowski, Józef R, Fulop, Vilmos, Challis, Gregory L
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biocatalysis Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Hydroxylation Indoles - chemistry Indoles - metabolism Models, Molecular Piperazines - chemistry Piperazines - metabolism Protein Conformation Substrate Specificity
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