Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes
Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane on induction of micronucleus (M...
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| Veröffentlicht in: | Environmental science and pollution research international 2019-02, Vol.26 (4), p.3530-3541 |
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| creator | Kargar Shouroki, Fatemeh Neghab, Masoud Mozdarani, Hossein Alipour, Hamzeh Yousefinejad, Saeed Fardid, Reza |
| description | Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane on induction of micronucleus (MN) and chromosomal aberrations (CAs) and to determine whether any associations exist between polymorphisms of GST genes and the level of genomic damage measured by MN and CAs assays. Sixty operating room personnel and 60 unexposed referent nurses were studied. The workers’ exposure to the IAs was determined. DNA damage was evaluated by MN and CAs assays. Additionally, the
GSTM1
,
GSTT1
, and
GSTP1
polymorphisms were detected. The mean concentrations of nitrous oxide, isoflurane, and sevoflurane were found to be 850.92 ± 919.78, 2.40 ± 0.86, and 0.18 ± 0.14 ppm, respectively. The frequency of MN and CAs in the exposed group was significantly higher than that of the non-exposed group. The frequency of MN was significantly higher in referent nurses with null
GSTT1
, compared to referent nurses with positive
GSTT1
. The frequency of MN was significantly higher in exposed individuals carrying the combined genotype of
GSTT1
(−),
GSTM1
(−), and
GSTP1 AG
as compared with subjects carrying a combination of
GSTT1
(+),
GSTM1
(+), and
GSTP1 AA
. Statistically significant associations were noted between exposure to the IAs, gender, and the combination of the three
GSTs
genotypes with MN frequency. These findings indicate that inhalation exposure to IAs induces genotoxic response and the polymorphisms of
GSTs
genes might modulate the effect of exposure to IAs on MN. |
| doi_str_mv | 10.1007/s11356-018-3859-0 |
| format | Article |
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GSTM1
,
GSTT1
, and
GSTP1
polymorphisms were detected. The mean concentrations of nitrous oxide, isoflurane, and sevoflurane were found to be 850.92 ± 919.78, 2.40 ± 0.86, and 0.18 ± 0.14 ppm, respectively. The frequency of MN and CAs in the exposed group was significantly higher than that of the non-exposed group. The frequency of MN was significantly higher in referent nurses with null
GSTT1
, compared to referent nurses with positive
GSTT1
. The frequency of MN was significantly higher in exposed individuals carrying the combined genotype of
GSTT1
(−),
GSTM1
(−), and
GSTP1 AG
as compared with subjects carrying a combination of
GSTT1
(+),
GSTM1
(+), and
GSTP1 AA
. Statistically significant associations were noted between exposure to the IAs, gender, and the combination of the three
GSTs
genotypes with MN frequency. These findings indicate that inhalation exposure to IAs induces genotoxic response and the polymorphisms of
GSTs
genes might modulate the effect of exposure to IAs on MN.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-018-3859-0</identifier><identifier>PMID: 30519912</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anesthetics ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Chromosome aberrations ; Damage assessment ; Deoxyribonucleic acid ; DNA ; DNA damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Environmental science ; Exposure ; Genes ; Genotoxicity ; Genotypes ; Glutathione transferase ; GSTM1 protein ; GSTT1 protein ; Inhalation ; Isoflurane ; Medical personnel ; Nitrous oxide ; Nurses ; Occupational exposure ; Personnel ; Research Article ; Respiration ; Sevoflurane ; Statistical analysis ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2019-02, Vol.26 (4), p.3530-3541</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-c9c6d91ef38a1c827c1620791a04a1d1480ca7bea07f6921a817c74aba53ee6f3</citedby><cites>FETCH-LOGICAL-c430t-c9c6d91ef38a1c827c1620791a04a1d1480ca7bea07f6921a817c74aba53ee6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-018-3859-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-018-3859-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30519912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kargar Shouroki, Fatemeh</creatorcontrib><creatorcontrib>Neghab, Masoud</creatorcontrib><creatorcontrib>Mozdarani, Hossein</creatorcontrib><creatorcontrib>Alipour, Hamzeh</creatorcontrib><creatorcontrib>Yousefinejad, Saeed</creatorcontrib><creatorcontrib>Fardid, Reza</creatorcontrib><title>Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane on induction of micronucleus (MN) and chromosomal aberrations (CAs) and to determine whether any associations exist between polymorphisms of GST genes and the level of genomic damage measured by MN and CAs assays. Sixty operating room personnel and 60 unexposed referent nurses were studied. The workers’ exposure to the IAs was determined. DNA damage was evaluated by MN and CAs assays. Additionally, the
GSTM1
,
GSTT1
, and
GSTP1
polymorphisms were detected. The mean concentrations of nitrous oxide, isoflurane, and sevoflurane were found to be 850.92 ± 919.78, 2.40 ± 0.86, and 0.18 ± 0.14 ppm, respectively. The frequency of MN and CAs in the exposed group was significantly higher than that of the non-exposed group. The frequency of MN was significantly higher in referent nurses with null
GSTT1
, compared to referent nurses with positive
GSTT1
. The frequency of MN was significantly higher in exposed individuals carrying the combined genotype of
GSTT1
(−),
GSTM1
(−), and
GSTP1 AG
as compared with subjects carrying a combination of
GSTT1
(+),
GSTM1
(+), and
GSTP1 AA
. Statistically significant associations were noted between exposure to the IAs, gender, and the combination of the three
GSTs
genotypes with MN frequency. These findings indicate that inhalation exposure to IAs induces genotoxic response and the polymorphisms of
GSTs
genes might modulate the effect of exposure to IAs on MN.</description><subject>Anesthetics</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Chromosome aberrations</subject><subject>Damage assessment</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Exposure</subject><subject>Genes</subject><subject>Genotoxicity</subject><subject>Genotypes</subject><subject>Glutathione transferase</subject><subject>GSTM1 protein</subject><subject>GSTT1 protein</subject><subject>Inhalation</subject><subject>Isoflurane</subject><subject>Medical personnel</subject><subject>Nitrous oxide</subject><subject>Nurses</subject><subject>Occupational exposure</subject><subject>Personnel</subject><subject>Research Article</subject><subject>Respiration</subject><subject>Sevoflurane</subject><subject>Statistical analysis</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFr3DAQhUVJaTZpf0AvQZBLD3E7I8mWdSwh3RRSWuj2LLRaOVawLVeyafffV8ZpAoWe3sB874nRI-QtwnsEkB8SIi-rArAueF2qAl6QDVYoCimUOiEbUEIUyIU4JWcpPQAwUEy-IqccSlQK2YbMWzeEKfz21k9HGhrqh9Z0ZvJhMB01g0tT6yZvU54P1E-JRreuU-tH-stPLc0EHUN37EMcW5_6tORsv-92eLXIlyyLOY_fkN67nPmavGxMl9ybRz0nPz7d7K5vi7uv28_XH-8KKzhMhVW2Oih0Da8N2ppJixUDqdCAMHhAUYM1cu8MyKZSDE2N0kph9qbkzlUNPyfv1twxhp9zvkX3PlnXdfmwMCfNUCrGWYVlRi__QR_CHPMnLFQJjEtV15nClbIxpBRdo8foexOPGkEvnei1E5070UsnGrLn4jF53vfu8OT4W0IG2AqkvBruXXx--v-pfwD1aJYu</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Kargar Shouroki, Fatemeh</creator><creator>Neghab, 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B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20190201</creationdate><title>Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes</title><author>Kargar Shouroki, Fatemeh ; Neghab, Masoud ; Mozdarani, Hossein ; Alipour, Hamzeh ; Yousefinejad, Saeed ; Fardid, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-c9c6d91ef38a1c827c1620791a04a1d1480ca7bea07f6921a817c74aba53ee6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anesthetics</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Chromosome aberrations</topic><topic>Damage assessment</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Exposure</topic><topic>Genes</topic><topic>Genotoxicity</topic><topic>Genotypes</topic><topic>Glutathione transferase</topic><topic>GSTM1 protein</topic><topic>GSTT1 protein</topic><topic>Inhalation</topic><topic>Isoflurane</topic><topic>Medical personnel</topic><topic>Nitrous oxide</topic><topic>Nurses</topic><topic>Occupational exposure</topic><topic>Personnel</topic><topic>Research Article</topic><topic>Respiration</topic><topic>Sevoflurane</topic><topic>Statistical analysis</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kargar Shouroki, Fatemeh</creatorcontrib><creatorcontrib>Neghab, Masoud</creatorcontrib><creatorcontrib>Mozdarani, Hossein</creatorcontrib><creatorcontrib>Alipour, Hamzeh</creatorcontrib><creatorcontrib>Yousefinejad, Saeed</creatorcontrib><creatorcontrib>Fardid, 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Int</addtitle><date>2019-02-01</date><risdate>2019</risdate><volume>26</volume><issue>4</issue><spage>3530</spage><epage>3541</epage><pages>3530-3541</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Due to their wide applications, concern exists regarding possible genotoxic effects of inhalational anesthetics (IAs) among operating room personnel. This study was undertaken to examine genotoxic properties of co-exposure to nitrous oxide, sevoflurane, and isoflurane on induction of micronucleus (MN) and chromosomal aberrations (CAs) and to determine whether any associations exist between polymorphisms of GST genes and the level of genomic damage measured by MN and CAs assays. Sixty operating room personnel and 60 unexposed referent nurses were studied. The workers’ exposure to the IAs was determined. DNA damage was evaluated by MN and CAs assays. Additionally, the
GSTM1
,
GSTT1
, and
GSTP1
polymorphisms were detected. The mean concentrations of nitrous oxide, isoflurane, and sevoflurane were found to be 850.92 ± 919.78, 2.40 ± 0.86, and 0.18 ± 0.14 ppm, respectively. The frequency of MN and CAs in the exposed group was significantly higher than that of the non-exposed group. The frequency of MN was significantly higher in referent nurses with null
GSTT1
, compared to referent nurses with positive
GSTT1
. The frequency of MN was significantly higher in exposed individuals carrying the combined genotype of
GSTT1
(−),
GSTM1
(−), and
GSTP1 AG
as compared with subjects carrying a combination of
GSTT1
(+),
GSTM1
(+), and
GSTP1 AA
. Statistically significant associations were noted between exposure to the IAs, gender, and the combination of the three
GSTs
genotypes with MN frequency. These findings indicate that inhalation exposure to IAs induces genotoxic response and the polymorphisms of
GSTs
genes might modulate the effect of exposure to IAs on MN.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30519912</pmid><doi>10.1007/s11356-018-3859-0</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2019-02, Vol.26 (4), p.3530-3541 |
| issn | 0944-1344 1614-7499 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Anesthetics Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Chromosome aberrations Damage assessment Deoxyribonucleic acid DNA DNA damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Environmental science Exposure Genes Genotoxicity Genotypes Glutathione transferase GSTM1 protein GSTT1 protein Inhalation Isoflurane Medical personnel Nitrous oxide Nurses Occupational exposure Personnel Research Article Respiration Sevoflurane Statistical analysis Waste Water Technology Water Management Water Pollution Control |
| title | Genotoxicity of inhalational anesthetics and its relationship with the polymorphisms of GSTT1, GSTM1, and GSTP1 genes |
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