Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil
This work aims to elucidate the chemical composition of two essential oil (EO) samples obtained from the leaves of Thymus vulgaris L. (Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty...
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| Veröffentlicht in: | Natural product communications 2017-04, Vol.12 (4), p.611-614 |
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| creator | Abdelli, Wafae Bahri, Fouad Romane, Abderrahmane Höferl, Martina Wanner, Juergen Schmidt, Erich Jirovetz, Leopold |
| description | This work aims to elucidate the chemical composition of two essential oil (EO) samples obtained from the leaves of Thymus vulgaris L. (Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty-six compounds could be identified by means of simultaneous GC-FID and GC-MS, accounting for 99.3% of total thyme oil of Mostaganem (EO.TM) and 99.0% of Tlemcen (EO.TT). In both samples, thymol was the major component, amounting to 59.5% (EO.TM) and 67.3% (EO.TT) of the total oil. EO.TT proved to be acutely toxic to mice at a dose of 4500 mg/kg p.o., whereas EO.TM did not show signs of acute toxicity, even at the highest dose tested (5000 mg/kg p.o.). Both EO samples were proven to possess anti-inflammatory activities, significantly reducing carrageenan-induced paw edema in mice (after 6 hours at a dose of 400 mg/kg p.o) at 58.4% for EO.TT and 50.4% for EO.TM, respectively. In conclusion, it could be demonstrated that EOs of T. vulgaris exhibit a considerable in vivo anti-inflammatory activity at non-toxic doses. |
| doi_str_mv | 10.1177/1934578X1701200435 |
| format | Article |
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(Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty-six compounds could be identified by means of simultaneous GC-FID and GC-MS, accounting for 99.3% of total thyme oil of Mostaganem (EO.TM) and 99.0% of Tlemcen (EO.TT). In both samples, thymol was the major component, amounting to 59.5% (EO.TM) and 67.3% (EO.TT) of the total oil. EO.TT proved to be acutely toxic to mice at a dose of 4500 mg/kg p.o., whereas EO.TM did not show signs of acute toxicity, even at the highest dose tested (5000 mg/kg p.o.). Both EO samples were proven to possess anti-inflammatory activities, significantly reducing carrageenan-induced paw edema in mice (after 6 hours at a dose of 400 mg/kg p.o) at 58.4% for EO.TT and 50.4% for EO.TM, respectively. In conclusion, it could be demonstrated that EOs of T. vulgaris exhibit a considerable in vivo anti-inflammatory activity at non-toxic doses.</description><identifier>ISSN: 1934-578X</identifier><identifier>EISSN: 1555-9475</identifier><identifier>DOI: 10.1177/1934578X1701200435</identifier><identifier>PMID: 30520607</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject><![CDATA[Animals ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - isolation & purification ; Edema - drug therapy ; Edema - immunology ; Female ; Humans ; Male ; Mice ; Microbial Sensitivity Tests ; Oils, Volatile - administration & dosage ; Oils, Volatile - chemistry ; Oils, Volatile - isolation & purification ; Plant Leaves - chemistry ; Plant Oils - administration & dosage ; Plant Oils - chemistry ; Plant Oils - isolation & purification ; Thymus Plant - chemistry]]></subject><ispartof>Natural product communications, 2017-04, Vol.12 (4), p.611-614</ispartof><rights>2017 SAGE Publications Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-89715548573dd2084bfce257cacfd39da1a6fa4fc1f8545f9d43acf9e019ca3c3</citedby><cites>FETCH-LOGICAL-c387t-89715548573dd2084bfce257cacfd39da1a6fa4fc1f8545f9d43acf9e019ca3c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200435$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1934578X1701200435$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21966,27853,27924,27925,44945,45333</link.rule.ids><linktorsrc>$$Uhttps://journals.sagepub.com/doi/full/10.1177/1934578X1701200435?utm_source=summon&utm_medium=discovery-provider$$EView_record_in_SAGE_Publications$$FView_record_in_$$GSAGE_Publications</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30520607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdelli, Wafae</creatorcontrib><creatorcontrib>Bahri, Fouad</creatorcontrib><creatorcontrib>Romane, Abderrahmane</creatorcontrib><creatorcontrib>Höferl, Martina</creatorcontrib><creatorcontrib>Wanner, Juergen</creatorcontrib><creatorcontrib>Schmidt, Erich</creatorcontrib><creatorcontrib>Jirovetz, Leopold</creatorcontrib><title>Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil</title><title>Natural product communications</title><addtitle>Nat Prod Commun</addtitle><description>This work aims to elucidate the chemical composition of two essential oil (EO) samples obtained from the leaves of Thymus vulgaris L. (Lamiaceae) collected in two regions of Northwestern Algeria (Tlemcen and Mostaganem) and to assess their in vivo acute toxicity and anti-inflammatory activity. Sixty-six compounds could be identified by means of simultaneous GC-FID and GC-MS, accounting for 99.3% of total thyme oil of Mostaganem (EO.TM) and 99.0% of Tlemcen (EO.TT). In both samples, thymol was the major component, amounting to 59.5% (EO.TM) and 67.3% (EO.TT) of the total oil. EO.TT proved to be acutely toxic to mice at a dose of 4500 mg/kg p.o., whereas EO.TM did not show signs of acute toxicity, even at the highest dose tested (5000 mg/kg p.o.). Both EO samples were proven to possess anti-inflammatory activities, significantly reducing carrageenan-induced paw edema in mice (after 6 hours at a dose of 400 mg/kg p.o) at 58.4% for EO.TT and 50.4% for EO.TM, respectively. In conclusion, it could be demonstrated that EOs of T. vulgaris exhibit a considerable in vivo anti-inflammatory activity at non-toxic doses.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Edema - drug therapy</subject><subject>Edema - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Oils, Volatile - administration & dosage</subject><subject>Oils, Volatile - chemistry</subject><subject>Oils, Volatile - isolation & purification</subject><subject>Plant Leaves - chemistry</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - chemistry</subject><subject>Plant Oils - isolation & purification</subject><subject>Thymus Plant - chemistry</subject><issn>1934-578X</issn><issn>1555-9475</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9rwzAQxUVpaUKaL9ChaOziRrKkyBqNSf9AIEsKXYpRZClRsK1UsgP-9lVI2qXQW-7gfu9x9wC4x-gJY85nWBDKePaBOcIpQpSwKzDGjLFEUM6u4xyB5ESMwDSEPYqVZRRRcQtGBLEUzREfg89ipxurZA0L1xxcsJ11LZRtBfO2s4ltTS2bRnbODzBXnT3aboDOwLzeam9lC9e7oekDPPb1Vnob4CIEHZXRcGXrO3BjZB309NIn4P15sS5ek-Xq5a3Il4kiGe-STPB4Oc0YJ1WVooxujNIp40oqUxFRSSznRlKjsMkYZUZUlMSV0AgLJYkiE_B49j1499Xr0JWNDUrXtWy160OZYi5SggQnEU3PqPIuBK9NefC2kX4oMSpPyZZ_k42ih4t_v2l09Sv5yTECszMQ5FaXe9f7Nv77n-U3sH-CKA</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Abdelli, Wafae</creator><creator>Bahri, Fouad</creator><creator>Romane, Abderrahmane</creator><creator>Höferl, Martina</creator><creator>Wanner, Juergen</creator><creator>Schmidt, Erich</creator><creator>Jirovetz, Leopold</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil</title><author>Abdelli, Wafae ; 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| subjects | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Edema - drug therapy Edema - immunology Female Humans Male Mice Microbial Sensitivity Tests Oils, Volatile - administration & dosage Oils, Volatile - chemistry Oils, Volatile - isolation & purification Plant Leaves - chemistry Plant Oils - administration & dosage Plant Oils - chemistry Plant Oils - isolation & purification Thymus Plant - chemistry |
| title | Chemical Composition and Anti-inflammatory Activity of Algerian Thymus vulgaris Essential Oil |
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