GATA transcription factors in development and disease

GATA transcription factors in development and disease

The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis. GATA proteins are essential for the development of tissues derived from all three germ layers, including the skin, bra...

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Veröffentlicht in:Development (Cambridge) 2018-10, Vol.145 (20)
Hauptverfasser: Tremblay, Mathieu, Sanchez-Ferras, Oraly, Bouchard, Maxime
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation
Disease
GATA Transcription Factors - metabolism
Growth and Development
Humans
Organogenesis
Transcription, Genetic
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creator Tremblay, Mathieu
Sanchez-Ferras, Oraly
Bouchard, Maxime
description The GATA family of transcription factors is of crucial importance during embryonic development, playing complex and widespread roles in cell fate decisions and tissue morphogenesis. GATA proteins are essential for the development of tissues derived from all three germ layers, including the skin, brain, gonads, liver, hematopoietic, cardiovascular and urogenital systems. The crucial activity of GATA factors is underscored by the fact that inactivating mutations in most GATA members lead to embryonic lethality in mouse models and are often associated with developmental diseases in humans. In this Primer, we discuss the unique and redundant functions of GATA proteins in tissue morphogenesis, with an emphasis on their regulation of lineage specification and early organogenesis.
doi_str_mv 10.1242/dev.164384
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subjects Animals
Cell Differentiation
Disease
GATA Transcription Factors - metabolism
Growth and Development
Humans
Organogenesis
Transcription, Genetic
title GATA transcription factors in development and disease
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