Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β‑Sheet Structure Formed by Amyloid β‑Protein on GM1 Clusters

The abnormal aggregation of amyloid β-protein (Aβ) is considered central in the pathogenesis of Alzheimer’s disease. We focused on membrane-mediated amyloidogenesis and found that amyloid fibrils formed on monosialoganglioside GM1 clusters were more toxic than those formed in aqueous solution. In th...

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Veröffentlicht in:	ACS chemical neuroscience 2019-01, Vol.10 (1), p.563-572
Hauptverfasser:	Okada, Yuki, Okubo, Kaori, Ikeda, Keisuke, Yano, Yoshiaki, Hoshino, Masaru, Hayashi, Yoshio, Kiso, Yoshiaki, Itoh-Watanabe, Hikari, Naito, Akira, Matsuzaki, Katsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid - chemistry Amyloid - metabolism Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloidogenic Proteins - metabolism Amyloidosis - metabolism G(M1) Ganglioside - chemistry G(M1) Ganglioside - metabolism Humans Peptide Fragments - metabolism Protein Structure, Secondary - physiology
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