Neuropathology as a consequence of neonatal ventilation in premature growth-restricted lambs

Fetal growth restriction (FGR) and prematurity are associated with high risk of brain injury and long-term neurological deficits. FGR infants born preterm are commonly exposed to mechanical ventilation, but it is not known whether ventilation differentially induces brain pathology in FGR infants com...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2018-12, Vol.315 (6), p.R1183-R1194
Hauptverfasser:	Malhotra, Atul, Castillo-Melendez, Margie, Allison, Beth J, Sutherland, Amy E, Nitsos, Ilias, Pham, Yen, Alves de Alencar Rocha, Anna K, Fahey, Michael C, Polglase, Graeme R, Jenkin, Graham, Miller, Suzanne L
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxynonenal Apoptosis Babies Blood flow Blood-brain barrier Brain injury Caspase Caspase-3 Cerebral blood flow Cortex Extravasation Fetuses Gestation Gestational age Head injuries Health risks Infants Inflammation Lactic acid Mechanical ventilation Microglia Neonates Neurological diseases Neuropathology Oxidative stress Permeability Premature birth Sheep Substantia alba Substantia grisea Subventricular zone Ventilation
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