Sex Differences in Prevalence, Symptoms, Impact, and Psychiatric Comorbidities in Migraine and Probable Migraine: A Population‐Based Study
Objective This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample. Background While there is research on sex differences in clinical characteristics and their impact on migraine headach...
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| Veröffentlicht in: | Headache 2019-02, Vol.59 (2), p.215-223 |
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| creator | Song, Tae‐Jin Cho, Soo‐Jin Kim, Won‐Joo Yang, Kwang Ik Yun, Chang‐Ho Chu, Min Kyung |
| description | Objective
This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Background
While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings. Moreover, compared with Western countries, the prevalence of probable migraine in Asia is relatively high. This cross‐sectional study was designed to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Methods
We used the data of the Korean Headache‐Sleep Study, which is a nationwide survey on headache and sleep.
Results
We interviewed 7430 people, and 3114 of them agreed to participate in our study (rejection rate, 58.1%). Among these people, 419 withdrew their participation during the interview. Ultimately, 2695 people completed our survey (cooperation rate, 36.3%). The prevalence of overall migraine and probable migraine was 350/1350 (25.9%) for women and 172/1345 (12.8%) for men (P |
| doi_str_mv | 10.1111/head.13470 |
| format | Article |
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This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Background
While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings. Moreover, compared with Western countries, the prevalence of probable migraine in Asia is relatively high. This cross‐sectional study was designed to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Methods
We used the data of the Korean Headache‐Sleep Study, which is a nationwide survey on headache and sleep.
Results
We interviewed 7430 people, and 3114 of them agreed to participate in our study (rejection rate, 58.1%). Among these people, 419 withdrew their participation during the interview. Ultimately, 2695 people completed our survey (cooperation rate, 36.3%). The prevalence of overall migraine and probable migraine was 350/1350 (25.9%) for women and 172/1345 (12.8%) for men (P < .001, respectively). The prevalence of migraine (107/1350 [7.9%] vs 36/1345 [2.7%], P < .001) and probable migraine (243/1350 [18.0%] vs 136/1345 [10.1%], P < .001) was significantly higher among women than among men. Headache frequency per month (median [interquartile range]) (1.0 [0.3–3.0] vs 0.8 [0.3–2.0], P = .037), the visual analog scale score for headache intensity (5.0 [4.0–7.0] vs 5.0 [3.0–6.0], P = .019), and the impact of headache {Headache Impact Test‐6 score (47.0 [42.0–54.0] vs 44.0 [42.0–51.8], P = .013)} were significantly higher among women with probable migraine than men. Headache frequency per month (2.0 [0.4–4.0] vs 1.0 [0.3–2.0], P = .073), headache intensity (6.0 [5.0–8.0] vs 6.0 [4.2–7.0], P = .281), and the impact of headache (55.0 [48.0–61.0] vs 49.0 [46.3–60.8], P = .225) were not significantly different between women and men with migraine. Other comorbidities or associated symptoms, such as anxiety and depression, were not significantly different between women and men with migraine and probable migraine, except for nausea in probable migraine.
Conclusion
Women experience more severe symptoms and a higher impact of headache than men among participants with probable migraine. Our findings suggest that women with PM need a more intensive evaluation and treatment than men with PM.</description><identifier>ISSN: 0017-8748</identifier><identifier>EISSN: 1526-4610</identifier><identifier>DOI: 10.1111/head.13470</identifier><identifier>PMID: 30623976</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age Factors ; Anxiety ; Anxiety - epidemiology ; Anxiety - psychology ; Comorbidity ; Depression - epidemiology ; Depression - psychology ; disability ; Disability Evaluation ; epidemiology ; Female ; gender ; Gender aspects ; Gender differences ; Headache ; Headaches ; Health Surveys ; Humans ; Impact tests ; Male ; Men ; Mental depression ; Middle Aged ; Migraine ; Migraine Disorders - diagnosis ; Migraine Disorders - epidemiology ; Migraine Disorders - psychology ; Nausea ; Population ; Population studies ; Population-based studies ; Prevalence ; probable migraine ; Psychiatric Status Rating Scales ; Rejection rate ; Republic of Korea - epidemiology ; Severity of Illness Index ; Sex ; Sex differences ; Sex Factors ; Signs and symptoms ; Sleep ; Studies ; Women</subject><ispartof>Headache, 2019-02, Vol.59 (2), p.215-223</ispartof><rights>2019 American Headache Society</rights><rights>2019 American Headache Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4230-c7d063ef62a2506262995c20f4b79893a9ba68036c257daf0a8a70ff695fcdc63</citedby><cites>FETCH-LOGICAL-c4230-c7d063ef62a2506262995c20f4b79893a9ba68036c257daf0a8a70ff695fcdc63</cites><orcidid>0000-0001-6221-1346 ; 0000-0002-4053-3763</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fhead.13470$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fhead.13470$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30623976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Tae‐Jin</creatorcontrib><creatorcontrib>Cho, Soo‐Jin</creatorcontrib><creatorcontrib>Kim, Won‐Joo</creatorcontrib><creatorcontrib>Yang, Kwang Ik</creatorcontrib><creatorcontrib>Yun, Chang‐Ho</creatorcontrib><creatorcontrib>Chu, Min Kyung</creatorcontrib><title>Sex Differences in Prevalence, Symptoms, Impact, and Psychiatric Comorbidities in Migraine and Probable Migraine: A Population‐Based Study</title><title>Headache</title><addtitle>Headache</addtitle><description>Objective
This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Background
While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings. Moreover, compared with Western countries, the prevalence of probable migraine in Asia is relatively high. This cross‐sectional study was designed to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Methods
We used the data of the Korean Headache‐Sleep Study, which is a nationwide survey on headache and sleep.
Results
We interviewed 7430 people, and 3114 of them agreed to participate in our study (rejection rate, 58.1%). Among these people, 419 withdrew their participation during the interview. Ultimately, 2695 people completed our survey (cooperation rate, 36.3%). The prevalence of overall migraine and probable migraine was 350/1350 (25.9%) for women and 172/1345 (12.8%) for men (P < .001, respectively). The prevalence of migraine (107/1350 [7.9%] vs 36/1345 [2.7%], P < .001) and probable migraine (243/1350 [18.0%] vs 136/1345 [10.1%], P < .001) was significantly higher among women than among men. Headache frequency per month (median [interquartile range]) (1.0 [0.3–3.0] vs 0.8 [0.3–2.0], P = .037), the visual analog scale score for headache intensity (5.0 [4.0–7.0] vs 5.0 [3.0–6.0], P = .019), and the impact of headache {Headache Impact Test‐6 score (47.0 [42.0–54.0] vs 44.0 [42.0–51.8], P = .013)} were significantly higher among women with probable migraine than men. Headache frequency per month (2.0 [0.4–4.0] vs 1.0 [0.3–2.0], P = .073), headache intensity (6.0 [5.0–8.0] vs 6.0 [4.2–7.0], P = .281), and the impact of headache (55.0 [48.0–61.0] vs 49.0 [46.3–60.8], P = .225) were not significantly different between women and men with migraine. Other comorbidities or associated symptoms, such as anxiety and depression, were not significantly different between women and men with migraine and probable migraine, except for nausea in probable migraine.
Conclusion
Women experience more severe symptoms and a higher impact of headache than men among participants with probable migraine. Our findings suggest that women with PM need a more intensive evaluation and treatment than men with PM.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Anxiety</subject><subject>Anxiety - epidemiology</subject><subject>Anxiety - psychology</subject><subject>Comorbidity</subject><subject>Depression - epidemiology</subject><subject>Depression - psychology</subject><subject>disability</subject><subject>Disability Evaluation</subject><subject>epidemiology</subject><subject>Female</subject><subject>gender</subject><subject>Gender aspects</subject><subject>Gender differences</subject><subject>Headache</subject><subject>Headaches</subject><subject>Health Surveys</subject><subject>Humans</subject><subject>Impact tests</subject><subject>Male</subject><subject>Men</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Migraine</subject><subject>Migraine Disorders - diagnosis</subject><subject>Migraine Disorders - epidemiology</subject><subject>Migraine Disorders - psychology</subject><subject>Nausea</subject><subject>Population</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Prevalence</subject><subject>probable migraine</subject><subject>Psychiatric Status Rating Scales</subject><subject>Rejection rate</subject><subject>Republic of Korea - epidemiology</subject><subject>Severity of Illness Index</subject><subject>Sex</subject><subject>Sex differences</subject><subject>Sex Factors</subject><subject>Signs and symptoms</subject><subject>Sleep</subject><subject>Studies</subject><subject>Women</subject><issn>0017-8748</issn><issn>1526-4610</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90ctu1DAUBmALgehQ2PAAyBIbhCbFl8SO2Q3TQisVMdLAOjrxhbpK4tROgOx4ABY8I09ChpQuWOCNZevzr2P9CD2l5ITO69WVBXNCeS7JPbSiBRNZLii5j1aEUJmVMi-P0KOUrgkhuVDiITriRDCupFihH3v7DZ9652y0nbYJ-w7vov0CzeG4xvup7YfQpjW-aHvQwxpDZ_AuTfrKwxC9xtvQhlh74we_PH_vP0fwnV1kDDXUjb27fY03eBf6sYHBh-7X959vIFmD98NopsfogYMm2Se3-zH69Pbs4_Y8u_zw7mK7ucx0zjjJtDREcOsEA1bMPxFMqUIz4vJaqlJxUDWIknChWSENOAIlSOKcUIXTRgt-jF4suX0MN6NNQ9X6pG3TQGfDmCpGRSEEyemBPv-HXocxdvN0s5JUSckZndXLRekYUorWVX30LcSpoqQ6dFQdOqr-dDTjZ7eRY91ac0f_ljIDuoCvvrHTf6Kq87PN6RL6GwuInJ4</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Song, Tae‐Jin</creator><creator>Cho, Soo‐Jin</creator><creator>Kim, Won‐Joo</creator><creator>Yang, Kwang Ik</creator><creator>Yun, Chang‐Ho</creator><creator>Chu, Min Kyung</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6221-1346</orcidid><orcidid>https://orcid.org/0000-0002-4053-3763</orcidid></search><sort><creationdate>201902</creationdate><title>Sex Differences in Prevalence, Symptoms, Impact, and Psychiatric Comorbidities in Migraine and Probable Migraine: A Population‐Based Study</title><author>Song, Tae‐Jin ; Cho, Soo‐Jin ; Kim, Won‐Joo ; Yang, Kwang Ik ; Yun, Chang‐Ho ; Chu, Min Kyung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4230-c7d063ef62a2506262995c20f4b79893a9ba68036c257daf0a8a70ff695fcdc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Anxiety</topic><topic>Anxiety - epidemiology</topic><topic>Anxiety - psychology</topic><topic>Comorbidity</topic><topic>Depression - epidemiology</topic><topic>Depression - psychology</topic><topic>disability</topic><topic>Disability Evaluation</topic><topic>epidemiology</topic><topic>Female</topic><topic>gender</topic><topic>Gender aspects</topic><topic>Gender differences</topic><topic>Headache</topic><topic>Headaches</topic><topic>Health Surveys</topic><topic>Humans</topic><topic>Impact tests</topic><topic>Male</topic><topic>Men</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Migraine</topic><topic>Migraine Disorders - diagnosis</topic><topic>Migraine Disorders - epidemiology</topic><topic>Migraine Disorders - psychology</topic><topic>Nausea</topic><topic>Population</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Prevalence</topic><topic>probable migraine</topic><topic>Psychiatric Status Rating Scales</topic><topic>Rejection rate</topic><topic>Republic of Korea - epidemiology</topic><topic>Severity of Illness Index</topic><topic>Sex</topic><topic>Sex differences</topic><topic>Sex Factors</topic><topic>Signs and symptoms</topic><topic>Sleep</topic><topic>Studies</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Tae‐Jin</creatorcontrib><creatorcontrib>Cho, Soo‐Jin</creatorcontrib><creatorcontrib>Kim, Won‐Joo</creatorcontrib><creatorcontrib>Yang, Kwang Ik</creatorcontrib><creatorcontrib>Yun, Chang‐Ho</creatorcontrib><creatorcontrib>Chu, Min Kyung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Headache</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Tae‐Jin</au><au>Cho, Soo‐Jin</au><au>Kim, Won‐Joo</au><au>Yang, Kwang Ik</au><au>Yun, Chang‐Ho</au><au>Chu, Min Kyung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex Differences in Prevalence, Symptoms, Impact, and Psychiatric Comorbidities in Migraine and Probable Migraine: A Population‐Based Study</atitle><jtitle>Headache</jtitle><addtitle>Headache</addtitle><date>2019-02</date><risdate>2019</risdate><volume>59</volume><issue>2</issue><spage>215</spage><epage>223</epage><pages>215-223</pages><issn>0017-8748</issn><eissn>1526-4610</eissn><abstract>Objective
This study was conducted to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Background
While there is research on sex differences in clinical characteristics and their impact on migraine headache, only few studies have investigated sex differences in probable migraine in population‐based settings. Moreover, compared with Western countries, the prevalence of probable migraine in Asia is relatively high. This cross‐sectional study was designed to investigate sex differences in the prevalence and clinical presentation of migraine and probable migraine in a general population‐based sample.
Methods
We used the data of the Korean Headache‐Sleep Study, which is a nationwide survey on headache and sleep.
Results
We interviewed 7430 people, and 3114 of them agreed to participate in our study (rejection rate, 58.1%). Among these people, 419 withdrew their participation during the interview. Ultimately, 2695 people completed our survey (cooperation rate, 36.3%). The prevalence of overall migraine and probable migraine was 350/1350 (25.9%) for women and 172/1345 (12.8%) for men (P < .001, respectively). The prevalence of migraine (107/1350 [7.9%] vs 36/1345 [2.7%], P < .001) and probable migraine (243/1350 [18.0%] vs 136/1345 [10.1%], P < .001) was significantly higher among women than among men. Headache frequency per month (median [interquartile range]) (1.0 [0.3–3.0] vs 0.8 [0.3–2.0], P = .037), the visual analog scale score for headache intensity (5.0 [4.0–7.0] vs 5.0 [3.0–6.0], P = .019), and the impact of headache {Headache Impact Test‐6 score (47.0 [42.0–54.0] vs 44.0 [42.0–51.8], P = .013)} were significantly higher among women with probable migraine than men. Headache frequency per month (2.0 [0.4–4.0] vs 1.0 [0.3–2.0], P = .073), headache intensity (6.0 [5.0–8.0] vs 6.0 [4.2–7.0], P = .281), and the impact of headache (55.0 [48.0–61.0] vs 49.0 [46.3–60.8], P = .225) were not significantly different between women and men with migraine. Other comorbidities or associated symptoms, such as anxiety and depression, were not significantly different between women and men with migraine and probable migraine, except for nausea in probable migraine.
Conclusion
Women experience more severe symptoms and a higher impact of headache than men among participants with probable migraine. Our findings suggest that women with PM need a more intensive evaluation and treatment than men with PM.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30623976</pmid><doi>10.1111/head.13470</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6221-1346</orcidid><orcidid>https://orcid.org/0000-0002-4053-3763</orcidid></addata></record> |
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| ispartof | Headache, 2019-02, Vol.59 (2), p.215-223 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Age Factors Anxiety Anxiety - epidemiology Anxiety - psychology Comorbidity Depression - epidemiology Depression - psychology disability Disability Evaluation epidemiology Female gender Gender aspects Gender differences Headache Headaches Health Surveys Humans Impact tests Male Men Mental depression Middle Aged Migraine Migraine Disorders - diagnosis Migraine Disorders - epidemiology Migraine Disorders - psychology Nausea Population Population studies Population-based studies Prevalence probable migraine Psychiatric Status Rating Scales Rejection rate Republic of Korea - epidemiology Severity of Illness Index Sex Sex differences Sex Factors Signs and symptoms Sleep Studies Women |
| title | Sex Differences in Prevalence, Symptoms, Impact, and Psychiatric Comorbidities in Migraine and Probable Migraine: A Population‐Based Study |
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