Determination of glyoxal, methylglyoxal, and diacetyl in red ginseng products using dispersive liquid–liquid microextraction coupled with GC–MS
A simple and rapid dispersive liquid–liquid microextraction method coupled with gas chromatography and mass spectrometry was applied for the determination of glyoxal as quinoxaline, methylglyoxal as 2‐methylquinoxaline, and diacetyl as 2,3‐dimethylquinoxaline in red ginseng products. The performance...
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| Veröffentlicht in: | Journal of separation science 2019-03, Vol.42 (6), p.1230-1239 |
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| creator | Lee, Yun‐Yeol Shibamoto, Takayuki Ha, Sang‐Do Ha, Jaeho Lee, Jangho Jang, Hae Won |
| description | A simple and rapid dispersive liquid–liquid microextraction method coupled with gas chromatography and mass spectrometry was applied for the determination of glyoxal as quinoxaline, methylglyoxal as 2‐methylquinoxaline, and diacetyl as 2,3‐dimethylquinoxaline in red ginseng products. The performance of the proposed method was evaluated under optimum extraction conditions (extraction solvent: chloroform 100 μL, disperser solvent: methanol 200 μL, derivatizing agent concentration: 5 g/L, reaction time: 1 h, and no addition of salt). The limit of detection and limit of quantitation were 1.30 and 4.33 μg/L for glyoxal, 1.86 and 6.20 μg/L for methylglyoxal, and 1.45 and 4.82 μg/L for diacetyl. The intra‐ and interday relative standard deviations were |
| doi_str_mv | 10.1002/jssc.201800841 |
| format | Article |
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The performance of the proposed method was evaluated under optimum extraction conditions (extraction solvent: chloroform 100 μL, disperser solvent: methanol 200 μL, derivatizing agent concentration: 5 g/L, reaction time: 1 h, and no addition of salt). The limit of detection and limit of quantitation were 1.30 and 4.33 μg/L for glyoxal, 1.86 and 6.20 μg/L for methylglyoxal, and 1.45 and 4.82 μg/L for diacetyl. The intra‐ and interday relative standard deviations were <4.95 and 5.80%, respectively. The relative recoveries were 92.4–103.9% in red ginseng concentrate and 99.4–110.7% in juice samples. Red ginseng concentrates were found to contain 191–4274 μg/kg of glyoxal, 1336–4798 μg/kg of methylglyoxal, and 0–830 μg/kg of diacetyl, whereas for red ginseng juices, the respective concentrations were 72–865, 69–3613, and 6–344 μg/L.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201800841</identifier><identifier>PMID: 30624019</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chloroform ; diacetyl ; Diacetyl - analysis ; Dispersion ; dispersive liquid–liquid microextraction ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; glyoxal ; Glyoxal - analysis ; Liquid Phase Microextraction ; Mass spectrometry ; methylglyoxal ; Panax - chemistry ; Pyruvaldehyde - analysis ; Quinoxalines ; Reaction time ; Reagents ; red ginseng products ; Solvents</subject><ispartof>Journal of separation science, 2019-03, Vol.42 (6), p.1230-1239</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-b97b917f46144f987e1f8b71fb8253ae9b3e39619f8a8a0229af91000f456fea3</citedby><cites>FETCH-LOGICAL-c4052-b97b917f46144f987e1f8b71fb8253ae9b3e39619f8a8a0229af91000f456fea3</cites><orcidid>0000-0002-4797-9880</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201800841$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201800841$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30624019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yun‐Yeol</creatorcontrib><creatorcontrib>Shibamoto, Takayuki</creatorcontrib><creatorcontrib>Ha, Sang‐Do</creatorcontrib><creatorcontrib>Ha, Jaeho</creatorcontrib><creatorcontrib>Lee, Jangho</creatorcontrib><creatorcontrib>Jang, Hae Won</creatorcontrib><title>Determination of glyoxal, methylglyoxal, and diacetyl in red ginseng products using dispersive liquid–liquid microextraction coupled with GC–MS</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>A simple and rapid dispersive liquid–liquid microextraction method coupled with gas chromatography and mass spectrometry was applied for the determination of glyoxal as quinoxaline, methylglyoxal as 2‐methylquinoxaline, and diacetyl as 2,3‐dimethylquinoxaline in red ginseng products. The performance of the proposed method was evaluated under optimum extraction conditions (extraction solvent: chloroform 100 μL, disperser solvent: methanol 200 μL, derivatizing agent concentration: 5 g/L, reaction time: 1 h, and no addition of salt). The limit of detection and limit of quantitation were 1.30 and 4.33 μg/L for glyoxal, 1.86 and 6.20 μg/L for methylglyoxal, and 1.45 and 4.82 μg/L for diacetyl. The intra‐ and interday relative standard deviations were <4.95 and 5.80%, respectively. The relative recoveries were 92.4–103.9% in red ginseng concentrate and 99.4–110.7% in juice samples. Red ginseng concentrates were found to contain 191–4274 μg/kg of glyoxal, 1336–4798 μg/kg of methylglyoxal, and 0–830 μg/kg of diacetyl, whereas for red ginseng juices, the respective concentrations were 72–865, 69–3613, and 6–344 μg/L.</description><subject>Chloroform</subject><subject>diacetyl</subject><subject>Diacetyl - analysis</subject><subject>Dispersion</subject><subject>dispersive liquid–liquid microextraction</subject><subject>Gas chromatography</subject><subject>Gas Chromatography-Mass Spectrometry</subject><subject>glyoxal</subject><subject>Glyoxal - analysis</subject><subject>Liquid Phase Microextraction</subject><subject>Mass spectrometry</subject><subject>methylglyoxal</subject><subject>Panax - chemistry</subject><subject>Pyruvaldehyde - analysis</subject><subject>Quinoxalines</subject><subject>Reaction time</subject><subject>Reagents</subject><subject>red ginseng products</subject><subject>Solvents</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkb-O1DAQxi0E4v5AS4ks0VDcLjOO48QlWuAAHaJYqCMnGe955SR7dsJdOt7h3pAnwcseW9BQeWb08zef_TH2AmGJAOLNNsZmKQBLgFLiI3aKCvOFzlA-PtagTthZjFsALEoNT9lJGgkJqE_Z_TsaKXSuN6Mbej5YvvHzcGf8Be9ovJ79sTV9y1tnGhpnz13PA7V84_pI_YbvwtBOzRj5FF1qWxd3FKL7Qdy7m8m1v37eHwreuSYMdDcG0_xZ2AzTzielWzde88tVAr-sn7En1vhIzx_Oc_b9w_tvq4-Lq6-Xn1ZvrxaNhFwsal3UGgsrFUppdVkQ2rIu0NalyDNDus4o0wq1LU1pQAhtrE6fBlbmypLJztnrg26yfzNRHKvOxYa8Nz0NU6wEqlwpgAIS-uofdDtMoU_uEqWVykvM9tTyQKU3xhjIVrvgOhPmCqHax1Xt46qOcaULLx9kp7qj9oj_zScB8gDcOk_zf-Sqz-v1SmUost8GvaTb</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Lee, Yun‐Yeol</creator><creator>Shibamoto, Takayuki</creator><creator>Ha, Sang‐Do</creator><creator>Ha, Jaeho</creator><creator>Lee, Jangho</creator><creator>Jang, Hae Won</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4797-9880</orcidid></search><sort><creationdate>201903</creationdate><title>Determination of glyoxal, methylglyoxal, and diacetyl in red ginseng products using dispersive liquid–liquid microextraction coupled with GC–MS</title><author>Lee, Yun‐Yeol ; Shibamoto, Takayuki ; Ha, Sang‐Do ; Ha, Jaeho ; Lee, Jangho ; Jang, Hae Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-b97b917f46144f987e1f8b71fb8253ae9b3e39619f8a8a0229af91000f456fea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chloroform</topic><topic>diacetyl</topic><topic>Diacetyl - analysis</topic><topic>Dispersion</topic><topic>dispersive liquid–liquid microextraction</topic><topic>Gas chromatography</topic><topic>Gas Chromatography-Mass Spectrometry</topic><topic>glyoxal</topic><topic>Glyoxal - analysis</topic><topic>Liquid Phase Microextraction</topic><topic>Mass spectrometry</topic><topic>methylglyoxal</topic><topic>Panax - chemistry</topic><topic>Pyruvaldehyde - analysis</topic><topic>Quinoxalines</topic><topic>Reaction time</topic><topic>Reagents</topic><topic>red ginseng products</topic><topic>Solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yun‐Yeol</creatorcontrib><creatorcontrib>Shibamoto, Takayuki</creatorcontrib><creatorcontrib>Ha, Sang‐Do</creatorcontrib><creatorcontrib>Ha, Jaeho</creatorcontrib><creatorcontrib>Lee, Jangho</creatorcontrib><creatorcontrib>Jang, Hae Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yun‐Yeol</au><au>Shibamoto, Takayuki</au><au>Ha, Sang‐Do</au><au>Ha, Jaeho</au><au>Lee, Jangho</au><au>Jang, Hae Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of glyoxal, methylglyoxal, and diacetyl in red ginseng products using dispersive liquid–liquid microextraction coupled with GC–MS</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2019-03</date><risdate>2019</risdate><volume>42</volume><issue>6</issue><spage>1230</spage><epage>1239</epage><pages>1230-1239</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>A simple and rapid dispersive liquid–liquid microextraction method coupled with gas chromatography and mass spectrometry was applied for the determination of glyoxal as quinoxaline, methylglyoxal as 2‐methylquinoxaline, and diacetyl as 2,3‐dimethylquinoxaline in red ginseng products. The performance of the proposed method was evaluated under optimum extraction conditions (extraction solvent: chloroform 100 μL, disperser solvent: methanol 200 μL, derivatizing agent concentration: 5 g/L, reaction time: 1 h, and no addition of salt). The limit of detection and limit of quantitation were 1.30 and 4.33 μg/L for glyoxal, 1.86 and 6.20 μg/L for methylglyoxal, and 1.45 and 4.82 μg/L for diacetyl. The intra‐ and interday relative standard deviations were <4.95 and 5.80%, respectively. The relative recoveries were 92.4–103.9% in red ginseng concentrate and 99.4–110.7% in juice samples. Red ginseng concentrates were found to contain 191–4274 μg/kg of glyoxal, 1336–4798 μg/kg of methylglyoxal, and 0–830 μg/kg of diacetyl, whereas for red ginseng juices, the respective concentrations were 72–865, 69–3613, and 6–344 μg/L.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30624019</pmid><doi>10.1002/jssc.201800841</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4797-9880</orcidid></addata></record> |
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| subjects | Chloroform diacetyl Diacetyl - analysis Dispersion dispersive liquid–liquid microextraction Gas chromatography Gas Chromatography-Mass Spectrometry glyoxal Glyoxal - analysis Liquid Phase Microextraction Mass spectrometry methylglyoxal Panax - chemistry Pyruvaldehyde - analysis Quinoxalines Reaction time Reagents red ginseng products Solvents |
| title | Determination of glyoxal, methylglyoxal, and diacetyl in red ginseng products using dispersive liquid–liquid microextraction coupled with GC–MS |
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