Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema

Acne vulgaris (AV), a severe chronic inflammatory dermatosis, commonly treated with systemic or topical antibiotics that exacerbate bacterial resistance and pose adverse side effects, new approaches for suppressing or reducing Propionibacterium acnes -induced inflammatory responses and thereby treat...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2019-05, Vol.392 (5), p.529-540
Hauptverfasser:	dos Santos, Zípora Morgana Quinteiro, dos Santos, Marlene Quinteiro, Zancanaro, Vilmair, Bellaver, Emyr Hiago, Nardi, Geisson Marcos, Gelinski, Jane Mary Lafayet, Locatelli, Claudriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Acne Acne Vulgaris - drug therapy Acne Vulgaris - metabolism Administration, Topical Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Antibiotics Antioxidants - pharmacology Antioxidants - therapeutic use Benzoyl peroxide Benzoyl Peroxide - pharmacology Benzoyl Peroxide - therapeutic use Biomedical and Life Sciences Biomedicine Catalase Chemical compounds Cosmetics Ear Edema Edema - drug therapy Edema - metabolism Gallic acid Gallic Acid - pharmacology Gallic Acid - therapeutic use Glutathione Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - metabolism IL-1β Inflammation Interleukin 1 Interleukin-1beta - metabolism Male Mice Neurosciences Original Article Oxidative stress Peroxidase Peroxidase - metabolism Peroxide Pharmacology/Toxicology Phenolic compounds Phenols Propionibacterium acnes Proteins Quercetin Quercetin - pharmacology Quercetin - therapeutic use Resveratrol Resveratrol - pharmacology Resveratrol - therapeutic use Superoxide Superoxide dismutase Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Topical application Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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