Reciprocal activation of cancer-associated fibroblasts and oral squamous carcinoma cells through CXCL1

•CXCL1 is associated with poor survival of oral cancer patients.•Cancer-associated fibroblasts (CAFs) are the predominant producer of CXCL1.•Tumor-derived IL-1β increases CXCL1 secretion of CAFs.•CAF-secreted CXCL1 promotes migration and invasion of oral cancer cells.•A reciprocal dependency is betw...

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Veröffentlicht in:	Oral oncology 2019-01, Vol.88, p.115-123
Hauptverfasser:	Wei, Ling-Ying, Lee, Jang-Jaer, Yeh, Chiou-Yueh, Yang, Chia-Ju, Kok, Sang-Heng, Ko, Jenq-Yuh, Tsai, Feng-Chiao, Chia, Jean-San
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Cancer-associated fibroblasts Cancer-Associated Fibroblasts - metabolism Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement - drug effects Chemokine CXCL1 - genetics Chemokine CXCL1 - immunology Chemokine CXCL1 - metabolism Coculture Techniques Culture Media, Conditioned CXCL1 Humans IL-1β Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-1beta - pharmacology Matrix metalloproteinase 1 Matrix Metalloproteinase 1 - metabolism Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Invasiveness Oral squamous cell carcinoma Paracrine Communication Phenylurea Compounds - pharmacology Progression-Free Survival Receptors, Interleukin-8B - antagonists & inhibitors Receptors, Interleukin-8B - genetics Survival rate Tumor Microenvironment
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