Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial
The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis. We randomly assigned 112 overweight or obese participants to four grou...
Gespeichert in:
| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2019-04, Vol.93, p.52-60 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | |
| container_start_page | 52 |
| container_title | Metabolism, clinical and experimental |
| container_volume | 93 |
| creator | Cho, A-Ra Moon, Ju-Yeon Kim, Sue An, Ki-Yong Oh, Minsuk Jeon, Justin Y. Jung, Dong-Hyuk Choi, Man Ho Lee, Ji-Won |
| description | The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.
We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography–mass spectrometry.
After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p |
| doi_str_mv | 10.1016/j.metabol.2019.01.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2165040721</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0026049519300095</els_id><sourcerecordid>2165040721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-7359e8c051c4a1c36bba6af9268dd003b346c780678e639fa1837d4117f925a3</originalsourceid><addsrcrecordid>eNqFkcFO3DAURa2qCAbKJ7Tykk3Cc5zYCRuEEC1ISGzYW479Ah458dT2UOgn9KtrNFO2Xdmyzr3P715CvjKoGTBxvq5nzHoMvm6ADTWwGqD5RFas403VC4DPZFVeRAXt0B2R45TWACBlLw7JEQfBuqGVK_LnZprQ5ETDRLXPGBedkVr9RiedslueqF4sxVeMxiWkYaHmOXhMhQye7r_g0kzdQsMLxl_onp4zDZGGEYtA263P6YJe0Y3zIdNY7MLsfqOlJiy5mPhyzdFp_4UcTNonPN2fJ-Tx-83j9W11__Dj7vrqvjItZ7mSvBuwN9Ax02pmuBhHLfQ0NKK3FoCPvBVG9iBkj4IPk2Y9l7ZlTBam0_yEnO1sNzH83JZN1OySQe_1gmGbVMNEBy3IhhW026EmhpQiTmoT3azjm2Kg3ltQa7WPQL23oICpknnRfduP2I4z2g_Vv9gLcLkDsOz54jCqZBwuBq2LpQ1lg_vPiL_OSJ1n</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2165040721</pqid></control><display><type>article</type><title>Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial</title><source>Elsevier ScienceDirect Journals Complete</source><creator>Cho, A-Ra ; Moon, Ju-Yeon ; Kim, Sue ; An, Ki-Yong ; Oh, Minsuk ; Jeon, Justin Y. ; Jung, Dong-Hyuk ; Choi, Man Ho ; Lee, Ji-Won</creator><creatorcontrib>Cho, A-Ra ; Moon, Ju-Yeon ; Kim, Sue ; An, Ki-Yong ; Oh, Minsuk ; Jeon, Justin Y. ; Jung, Dong-Hyuk ; Choi, Man Ho ; Lee, Ji-Won</creatorcontrib><description>The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.
We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography–mass spectrometry.
After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p < 0.05 by analysis of covariance [ANCOVA]). We found no differences in plant sterols, which are markers of cholesterol absorption. In the exercise group, desmosterol, cholesteryl esters, and oxysterols decreased significantly. Furthermore, only changes in physical activity levels negatively correlated with changes in the metabolic ratios of desmosterol and 7-dehydrocholesterol to cholesterol, which reflect cholesterol biosynthesis (r = −0.411; p = 0.030, and r = −0.540; p = 0.003, respectively).
These findings suggest that exercise with or without ADF improves cholesterol metabolism as measured by serum sterol signatures, and increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.
•Desmosterol, cholesteryl esters, and oxysterols decreased in the exercise group.•Increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.•Exercise, with or without alternate day fasting, improved cholesterol metabolism.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2019.01.002</identifier><identifier>PMID: 30615947</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Alternative day fasting ; Cholesterol metabolism ; Exercise ; Obesity ; Serum sterols</subject><ispartof>Metabolism, clinical and experimental, 2019-04, Vol.93, p.52-60</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-7359e8c051c4a1c36bba6af9268dd003b346c780678e639fa1837d4117f925a3</citedby><cites>FETCH-LOGICAL-c431t-7359e8c051c4a1c36bba6af9268dd003b346c780678e639fa1837d4117f925a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049519300095$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30615947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, A-Ra</creatorcontrib><creatorcontrib>Moon, Ju-Yeon</creatorcontrib><creatorcontrib>Kim, Sue</creatorcontrib><creatorcontrib>An, Ki-Yong</creatorcontrib><creatorcontrib>Oh, Minsuk</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><creatorcontrib>Jung, Dong-Hyuk</creatorcontrib><creatorcontrib>Choi, Man Ho</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><title>Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.
We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography–mass spectrometry.
After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p < 0.05 by analysis of covariance [ANCOVA]). We found no differences in plant sterols, which are markers of cholesterol absorption. In the exercise group, desmosterol, cholesteryl esters, and oxysterols decreased significantly. Furthermore, only changes in physical activity levels negatively correlated with changes in the metabolic ratios of desmosterol and 7-dehydrocholesterol to cholesterol, which reflect cholesterol biosynthesis (r = −0.411; p = 0.030, and r = −0.540; p = 0.003, respectively).
These findings suggest that exercise with or without ADF improves cholesterol metabolism as measured by serum sterol signatures, and increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.
•Desmosterol, cholesteryl esters, and oxysterols decreased in the exercise group.•Increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.•Exercise, with or without alternate day fasting, improved cholesterol metabolism.</description><subject>Alternative day fasting</subject><subject>Cholesterol metabolism</subject><subject>Exercise</subject><subject>Obesity</subject><subject>Serum sterols</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkcFO3DAURa2qCAbKJ7Tykk3Cc5zYCRuEEC1ISGzYW479Ah458dT2UOgn9KtrNFO2Xdmyzr3P715CvjKoGTBxvq5nzHoMvm6ADTWwGqD5RFas403VC4DPZFVeRAXt0B2R45TWACBlLw7JEQfBuqGVK_LnZprQ5ETDRLXPGBedkVr9RiedslueqF4sxVeMxiWkYaHmOXhMhQye7r_g0kzdQsMLxl_onp4zDZGGEYtA263P6YJe0Y3zIdNY7MLsfqOlJiy5mPhyzdFp_4UcTNonPN2fJ-Tx-83j9W11__Dj7vrqvjItZ7mSvBuwN9Ax02pmuBhHLfQ0NKK3FoCPvBVG9iBkj4IPk2Y9l7ZlTBam0_yEnO1sNzH83JZN1OySQe_1gmGbVMNEBy3IhhW026EmhpQiTmoT3azjm2Kg3ltQa7WPQL23oICpknnRfduP2I4z2g_Vv9gLcLkDsOz54jCqZBwuBq2LpQ1lg_vPiL_OSJ1n</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Cho, A-Ra</creator><creator>Moon, Ju-Yeon</creator><creator>Kim, Sue</creator><creator>An, Ki-Yong</creator><creator>Oh, Minsuk</creator><creator>Jeon, Justin Y.</creator><creator>Jung, Dong-Hyuk</creator><creator>Choi, Man Ho</creator><creator>Lee, Ji-Won</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20190401</creationdate><title>Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial</title><author>Cho, A-Ra ; Moon, Ju-Yeon ; Kim, Sue ; An, Ki-Yong ; Oh, Minsuk ; Jeon, Justin Y. ; Jung, Dong-Hyuk ; Choi, Man Ho ; Lee, Ji-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-7359e8c051c4a1c36bba6af9268dd003b346c780678e639fa1837d4117f925a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alternative day fasting</topic><topic>Cholesterol metabolism</topic><topic>Exercise</topic><topic>Obesity</topic><topic>Serum sterols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, A-Ra</creatorcontrib><creatorcontrib>Moon, Ju-Yeon</creatorcontrib><creatorcontrib>Kim, Sue</creatorcontrib><creatorcontrib>An, Ki-Yong</creatorcontrib><creatorcontrib>Oh, Minsuk</creatorcontrib><creatorcontrib>Jeon, Justin Y.</creatorcontrib><creatorcontrib>Jung, Dong-Hyuk</creatorcontrib><creatorcontrib>Choi, Man Ho</creatorcontrib><creatorcontrib>Lee, Ji-Won</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, A-Ra</au><au>Moon, Ju-Yeon</au><au>Kim, Sue</au><au>An, Ki-Yong</au><au>Oh, Minsuk</au><au>Jeon, Justin Y.</au><au>Jung, Dong-Hyuk</au><au>Choi, Man Ho</au><au>Lee, Ji-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>93</volume><spage>52</spage><epage>60</epage><pages>52-60</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>The objective of this pilot randomized controlled trial was to investigate the effect of alternate day fasting (ADF) and exercise on serum sterol signatures, which are surrogate markers of cholesterol absorption and biosynthesis.
We randomly assigned 112 overweight or obese participants to four groups: 1) ADF and exercise (E-ADF); 2) ADF; 3) exercise; and 4) control. We studied 31 completers in this exploratory analysis and measured their serum sterol signatures using gas chromatography–mass spectrometry.
After intervention, most serum sterol signatures that correspond to cholesterol metabolism were significantly different between groups (p < 0.05 by analysis of covariance [ANCOVA]). We found no differences in plant sterols, which are markers of cholesterol absorption. In the exercise group, desmosterol, cholesteryl esters, and oxysterols decreased significantly. Furthermore, only changes in physical activity levels negatively correlated with changes in the metabolic ratios of desmosterol and 7-dehydrocholesterol to cholesterol, which reflect cholesterol biosynthesis (r = −0.411; p = 0.030, and r = −0.540; p = 0.003, respectively).
These findings suggest that exercise with or without ADF improves cholesterol metabolism as measured by serum sterol signatures, and increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.
•Desmosterol, cholesteryl esters, and oxysterols decreased in the exercise group.•Increased physical activity has a greater effect on cholesterol biosynthesis than weight reduction or calorie restriction.•Exercise, with or without alternate day fasting, improved cholesterol metabolism.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30615947</pmid><doi>10.1016/j.metabol.2019.01.002</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-0495 |
| ispartof | Metabolism, clinical and experimental, 2019-04, Vol.93, p.52-60 |
| issn | 0026-0495 1532-8600 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2165040721 |
| source | Elsevier ScienceDirect Journals Complete |
| subjects | Alternative day fasting Cholesterol metabolism Exercise Obesity Serum sterols |
| title | Effects of alternate day fasting and exercise on cholesterol metabolism in overweight or obese adults: A pilot randomized controlled trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T18%3A16%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20alternate%20day%20fasting%20and%20exercise%20on%20cholesterol%20metabolism%20in%20overweight%20or%20obese%20adults:%20A%20pilot%20randomized%20controlled%20trial&rft.jtitle=Metabolism,%20clinical%20and%20experimental&rft.au=Cho,%20A-Ra&rft.date=2019-04-01&rft.volume=93&rft.spage=52&rft.epage=60&rft.pages=52-60&rft.issn=0026-0495&rft.eissn=1532-8600&rft_id=info:doi/10.1016/j.metabol.2019.01.002&rft_dat=%3Cproquest_cross%3E2165040721%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2165040721&rft_id=info:pmid/30615947&rft_els_id=S0026049519300095&rfr_iscdi=true |