Generation and characterization of antagonistic anti-human interleukin (IL)-18 monoclonal antibodies with high affinity: Two types of monoclonal antibodies against full-length IL-18 and the neoepitope of inflammatory caspase-cleaved active IL-18

Interleukin‐18 (IL‐18) is a pro-inflammatory cytokine that evokes both innate and acquired immune responses. IL-18 is initially synthesized as an inactive precursor and the cleavage for processing into a mature, active molecule is mediated by pro-inflammatory caspases following the activation of inf...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2019-03, Vol.663, p.71-82
Hauptverfasser:	Nariai, Yuko, Kamino, Hiroki, Obayashi, Eiji, Kato, Hiroaki, Sakashita, Gyosuke, Sugiura, Tomoko, Migita, Kiyoshi, Koga, Tomohiro, Kawakami, Atsushi, Sakamoto, Kazuma, Kadomatsu, Kenji, Nakakido, Makoto, Tsumoto, Kouhei, Urano, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - immunology Antibody Affinity Caspases - metabolism Cell Line, Tumor HEK293 Cells Humans Inflammation Mediators - immunology Inflammation Mediators - metabolism Interferon-gamma - metabolism Interleukin-18 - immunology Interleukin-18 - metabolism Proteolysis
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