Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs

Aberrant angiogenesis is a hallmark of various diseases including cancers. VEGFR-2 inhibitors have been utilized as anti-angiogenic agents for several years. However, compensatory activation of various receptor tyrosine kinases (RTK) could induce the occurrence of resistance. We previously reported...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-02, Vol.164, p.440-447
Hauptverfasser:	Shan, Yuanyuan, Si, Ru, Wang, Jin, Zhang, Qingqing, Zhou, Huaxin, Song, Jie, Zhang, Jie, Chen, Qinhua
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-Triazole Anti-angiogenic agents Compensatory activation Multi-target RTK inhibitors
Online-Zugang:	Volltext
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