Loss of IBA1-Expression in brains from individuals with obesity and hepatic dysfunction

•Areas, that were negative for IBA1, contained P2YR12 and GPX1-positive microglia.•Loss of IBA1-immunophenotype does not occur as a consequence of microglial senescence.•Number and extent of IBA1-negative regions was increased in obese cases.•Hepatic dysfunction strongly impacts the distribution of...

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Veröffentlicht in:	Brain research 2019-05, Vol.1710, p.220-229
Hauptverfasser:	Lier, Julia, Winter, Karsten, Bleher, Johannes, Grammig, Joachim, Mueller, Wolf C., Streit, Wolfgang, Bechmann, Ingo
Format:	Artikel
Sprache:	eng
Schlagworte:	Liver dysfunction Microglia Obesity
Online-Zugang:	Volltext
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