A new role for Drosophila Aurora-A in maintaining chromosome integrity

Aurora-A is a conserved mitotic kinase overexpressed in many types of cancer. Growing evidence shows that Aurora-A plays a crucial role in DNA damage response (DDR) although this aspect has been less characterized. We isolated a new aur-A mutation, named aur-A 949 , in Drosophila , and we showed tha...

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Veröffentlicht in:	Chromosoma 2019-03, Vol.128 (1), p.41-52
Hauptverfasser:	Merigliano, Chiara, Mascolo, Elisa, Cesta, Anthony, Saggio, Isabella, Vernì, Fiammetta
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Animals Aurora Kinase A - deficiency Aurora Kinase A - genetics Biochemistry Biomedical and Life Sciences Cancer Cell Biology Chromosome aberrations Chromosome Aberrations - radiation effects Chromosomes Chromosomes, Insect - chemistry Chromosomes, Insect - radiation effects Developmental Biology Dissolution DNA Damage DNA End-Joining Repair DNA Ligase ATP - genetics DNA Ligase ATP - metabolism DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila melanogaster - radiation effects Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Epistasis Epistasis, Genetic Eukaryotic Microbiology Female Genomic Instability Histones - genetics Histones - metabolism Homologous recombination Human Genetics Insects Life Sciences LIG4 protein Male Mutation Non-homologous end joining Original Article Phosphorylation Phosphorylation - radiation effects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteolysis - radiation effects X-Rays
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